Green Thumb Industries has filed applications with the U.S. Drug Enforcement Administration to register certain state-licensed medical marijuana operations under the new federal pathway created following the rescheduling of medical marijuana to Schedule III.

The company announced the move Monday, making it one of the most notable multistate operators to publicly confirm it is pursuing DEA registration following the federal policy shift.

Green Thumb, which owns RISE Dispensaries and operates in 14 U.S. markets, said the applications were submitted through the expedited registration process created in connection with medical marijuana’s move from Schedule I to Schedule III under the Controlled Substances Act.

“Schedule III changes the future of medical cannabis in America, and Green Thumb is ready for what comes next,” said Green Thumb Founder, Chairman and Chief Executive Officer Ben Kovler. “Rescheduling recognizes what millions of patients have known for years, opens the door to more research, and begins to fix the punitive tax treatment that has held responsible operators back. By seeking DEA registration, Green Thumb is taking a practical step toward a more normalized, regulated federal industry. We look forward to discussing this milestone along with our first quarter results with investors this Wednesday, May 6.”

Green Thumb operates more than 110 retail locations serving medical patients and adult-use consumers. The company also manufactures and sells several branded marijuana products, including RYTHM, incredibles, Dogwalkers, Beboe, &Shine, Doctor Solomon’s and Good Green.

The DEA registration process comes as marijuana businesses, regulators and investors continue assessing the implications of the federal rescheduling action, including its potential impact on research, medical access and federal tax treatment.

Green Thumb said it will release its first quarter 2026 financial results after the market closes Wednesday, May 6, with a conference call and webcast scheduled for 5 p.m. Eastern Time.