Researchers have developed a new platinum-based chemotherapy compound that combines cisplatin with cannabidiol (CBD), significantly enhancing its antitumor effects while overcoming drug resistance in cancer cells.
In a study published in the Journal of Inorganic Biochemistry, scientists from Kunming University of Science and Technology and Southeast University synthesized a series of platinum(IV) prodrugs (W1-W6), each axially conjugated with CBD. The most effective of these, known as W5, demonstrated potent activity against both platinum-sensitive and cisplatin-resistant tumor cell lines, especially in lung cancer cells (A549R).
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