A radiation-sensitive drug delivery system containing cannabidiol (CBD) reduced organ damage and increased survival among mice exposed to gamma radiation, according to a study published in Materials Today Bio.

Researchers developed polymer micelles containing CBD that were designed to remain stable under normal conditions but release the cannabinoid when exposed to gamma radiation. The micelles measured approximately 155 nanometers and incorporated radiation-sensitive diselenide bonds.

Laboratory testing found that the system responded even to low-dose gamma radiation, releasing more than 60% of its CBD within six hours. In the absence of radiation, the micelles retained their spherical structure, potentially limiting unnecessary drug exposure.

In irradiated mice, the CBD-loaded micelles promoted body-weight recovery, improved cellular and tissue uptake, reduced intracellular oxidative stress and protected multiple organs from radiation-related damage.

Treatment also increased the animals’ 30-day survival rate to more than 50%, according to the researchers.

Exposure to high levels of radiation can cause widespread cellular injury, oxidative stress and damage to organs and tissues. Although conventional radioprotective drugs are available, their potential toxicity has prompted researchers to explore alternative treatments and delivery methods.

The researchers concluded that the radiation-responsive CBD system offers a promising potential strategy for preventing and treating acute radiation injuries.