A new study from Universidade Federal do Amapá in Brazil reveals that combining extracts from Bixa orellana (also known as achiote) and cannabis significantly reduces pain in experimental models.
Bixa orellana and cannabis.
The findings, published in the journal Pharmaceuticals, suggest that these formulations could provide a powerful option for managing pain.
“The present study aimed to evaluate the potential synergy between pharmaceutical formulations containing Bixa orellana L. (granulated-CHR OR and injectable nanodispersion-CHR IN) in conjunction with a cannabidiol (CBD)-rich extract of Cannabis sativa L. (CSE) on experimental pain models in Wistar rats”, states the study’s abstract.
Researchers found that the “results from the experimental pain tests indicated that the combined administration of formulations containing Bixa orellana and C. sativa, such as the granulated CHR OR (400 mg/kg, orally) with CSE (40 mg/kg, orally) or the nanodispersion CHR IN (10 mg/kg, intramuscularly) with CSE (40 mg/kg, orally), demonstrated significant results in pain reduction.”
The study states that although the formulations containing Bixa orellana extract showed statistical significance in the tests when used in isolation, their effects were inferior compared to the combined use with CSE or the isolated use of CSE.
“These findings suggest that combining formulations containing extracts of these plant species may represent a viable therapeutic option, considering the synergistic action in reducing pain under the experimental conditions employed.”
The study concludes by stating that “these results imply that combining the phytocomplexes present in B. orellana and C. sativa may be a promising approach for pain treatment.”
