According to the results of a new study, cannabidiol (CBD) significantly strengthens the epithelial barrier in Peyer’s Patches and may support the prevention of inflammation-related conditions.
Conducted by researchers at Freie Universität Berlin and the University of Jordan, the study examined the effects of CBD on intestinal tissues using an ex vivo porcine model. Researchers focused on two types of gut lining: the follicle-associated epithelium of Peyer’s Patches (PP) and the villus epithelium (VE).
Using the Ussing chamber technique along with immunoblotting and confocal immunofluorescence imaging, the team measured barrier integrity and the expression of tight junction proteins. The results showed that CBD enhanced epithelial integrity in Peyer’s Patches by increasing the expression of key tight junction proteins, including occludin and claudins 1, 3, and 7.
Importantly, the study also found that CBD reduced the expression of TNFα receptor 1 in Peyer’s Patches. This receptor is known to play a major role in chronic inflammatory conditions such as inflammatory bowel disease (IBD), suggesting that CBD could hold promise in preventing or mitigating these disorders.
The findings highlight the potential therapeutic use of CBD in maintaining gut health and regulating immune responses in the intestines, particularly through its impact on Peyer’s Patches.
