In 2025, the U.S. legal-market cannabis scene continued to shift, as new strains, revived classics and consumer favorites all compete on dispensary shelves.
Based on an analysis of cannabis sales data across legal cannabis states, as well as cannabis review sites like Leafly, below are the 50 most popular cannabis strains throughout 2025.
Blue Dream
Runtz
Ice Cream Cake
Sour Diesel
Jack Herer
Apple Fritter
Permanent Marker
Gelato
Banana Cream Cake
Wedding Cake
Lemon Cherry Gelato
Tangie
Pineapple Fruz
Gary Payton
Gorilla Glue #4 (GG4)
Bruce Banner
Strawberry Banana
Cereal Milk
(Photo credit: Stiiizy).
Hash Burger
Carbon Fiber
Mochi
Grape Gas
Papaya Frosting
Alaskan Thunder
OG Kush
Girl Scout Cookies
Zkittlez
Oreoz
Jealousy
Khalifa Mints
RS11 (Rainbow Sherbet 11)
Biscotti
MAC (Miracle Alien Cookies)
Super Lemon Haze
Cherry Pie
GMO (Garlic Cookies)
Rainbow Belts
Donny Burger
Zoap
Pink Rozay
Apples and Bananas
White Truffle
Chemdawg
Durban Poison
San Fernando Valley OG
Peanut Butter Breath
Apple Tarts
Jet Fuel
Horchata
GMO x Jealousy
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