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Using data from the strain review site Leafly, the research firm Headset, state regulatory commissions and recent market-tracking reports, the following list highlights 20 of the most popular cannabis strains in the United States as of May 2026.

Blue Dream

Blue Dream remains one of the most widely recognized and commercially resilient strains in the country. A sativa-leaning hybrid, it has maintained strong demand because of its approachable potency, broad availability and consistent consumer familiarity.

Runtz

Runtz continues to perform well across multiple adult-use markets, helped by its Gelato and Zkittlez lineage and strong brand recognition. Its popularity reflects the ongoing consumer preference for dessert-forward hybrids with high THC levels, colorful flower structure and a balance of cerebral and physical effects.

Wedding Cake

Wedding Cake remains a major player in both flower and derivative markets, with demand driven by its potency, dense bud structure and long-standing reputation among experienced consumers. The strain’s popularity has also been boosted by its use as a parent in numerous newer hybrids.

GMO Cookies

GMO Cookies remains a standout among gas-heavy, high-potency hybrids. Its garlic-and-fuel terpene profile is more polarizing than many dessert strains, but that distinction has helped it maintain a dedicated consumer base in mature legal markets.

Gelato

Gelato remains one of the defining strains of the modern marijuana market. Known for its dessert-like terpene profile and consistent hybrid effects, it continues to appear in dispensaries nationwide, while also serving as a genetic backbone for many of today’s most commercially successful strains.

Sour Diesel

Sour Diesel continues to hold its place among the most popular sativa-dominant strains in the U.S. Its sharp aroma, long history and reputation for clear-headed effects have allowed it to stay relevant in mature markets where many older strains have faded from menus.

Permanent Marker

Permanent Marker has become one of the strongest newer entrants in the national strain conversation. Its rise reflects growing demand for high-potency hybrids with unusual terpene profiles, particularly those combining gas, floral and chemical-like aromas that appeal to experienced consumers.

Lemon Cherry Gelato

Lemon Cherry Gelato remains one of the most visible modern hybrids in the U.S. marijuana market. Its popularity stems from a combination of recognizable Gelato genetics, strong bag appeal and a terpene profile that blends citrus, berry and creamy notes without relying on old-school strain branding.

Animal Face

Animal Face has gained a firm foothold in several regulated markets, particularly among consumers looking for stronger indica-leaning options. Its popularity appears tied to its high-potency reputation, dense flower structure and suitability for evening use among more experienced consumers.

Granddaddy Purple

Granddaddy Purple remains one of the most enduring indica strains in the country. While newer genetics dominate many dispensary menus, GDP continues to draw consumers looking for a familiar strain associated with deep relaxation, grape-forward aromatics and a long-established medical marijuana presence.

Pineapple Express

Apple Fritter

Super Boof

Jack Herer

OG Kush

Girl Scout Cookies

MAC

Brownie Scout

Kush Mints

Northern Lights