Study: Abnormal Cannabinoids Show Potent Antifungal Activity Against Candida Species

In a new study, scientists have uncovered a powerful new use for abnormal cannabinoid (AbnCBD) derivatives.

These unique compounds, distinct from traditional cannabinoids, have shown remarkable effectiveness in combating drug-resistant Candida species, notes the study’s researchers. Published in Pharmacological Research, the study reveals how these derivatives not only inhibit fungal growth but also disrupt biofilm formation, offering a promising new approach to battling antifungal resistance.

The research was conducted by scientists from the University of Jerusalem, Ariel University, and The Hebrew University of Jerusalem. Their work focused on abnormal cannabinoids, a class of synthetic lipid compounds that, unlike traditional cannabinoids, do not interact with CB1 and CB2 receptors. Previous studies highlighted the cardioprotective and anti-inflammatory properties of one compound in particular, comp 3, as well as its antimicrobial potential against methicillin-resistant Staphylococcus aureus (MRSA).
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Study: Cannabinoids Show “Promising Potential” in Cancer Treatment

Published in the journal Discover Oncology, a comprehensive review conducted by researchers from institutions in Pakistan, Portugal, Turkey, Saudi Arabia, and South Korea investigates the potential role of cannabinoids in cancer treatment.

The collaboration includes the Pakistan National University of Sciences and Technology, the University of the Punjab, and The Islamia University of Bahawalpur, along with international partners from the Polytechnic Institute of Bragança, Fırat University, Shaqra University, and Korea University. The study was also published online by the US National Library of Medicine.

Cannabinoids, known for centuries in traditional medicine, are gaining renewed attention for their therapeutic properties, particularly in cancer care. The study highlights how compounds like Δ9-THC, CBD, and CBG show promising effects in fighting cancer by influencing critical cellular processes such as inducing apoptosis (programmed cell death), stimulating autophagy (cell cleanup), and inhibiting metastasis and angiogenesis (tumor growth through blood vessel formation). These findings are based on an extensive review of literature from databases like PubMed, Google Scholar, Web of Science, Scopus, and Embase.
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SAFE Banking Act Gains 131st Sponsor in US House

The SAFE Banking Act now has 131 sponsors in the US House of Representatives.

On October 1, Congressmember Amu Bera (D-CA) became the latest lawmaker to join as a sponsor for the SAFE Banking Act (H.R. 2891). The measure now has 131 bipartisan sponsors, more than any other marijuana-related bill in the U.S. Congress.

The SAFE Banking Act is designed to establish federal protections for banks and credit unions that work with marijuana businesses operating legally under state law. This applies to thousands of dispensaries and retail outlets across the 38 states with medical marijuana programs, as well as the 23 states that allow recreational sales. The bill would also allow these businesses to take standard IRS tax deductions, which they are currently denied.
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Illinois Marijuana Sales Surpass $165 Million in September, Bringing Year-to-Date Total Above $1.5 Billion

Illinois’ legal marijuana market remained steady in September, with licensed retail outlets and dispensaries selling $167.9 million worth of product, according to data from the Illinois Cannabis Regulation Oversight Officer.

Approximately 85% of these sales were made by recreational consumers, while medical marijuana purchases accounted for 15% of the total. Nearly one in four recreational marijuana purchases was made by non-residents, with Illinois residents responsible for around 77% of the sales.

Year-to-date, marijuana sales in Illinois have surpassed $1.5 billion, generating over $275 million in tax revenue.
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Ohio: Nearly $140 Million in Legal Marijuana Sold in Past Seven Weeks

Sales in Ohio’s recreational marijuana market have reached nearly $90 million, just seven weeks after its launch.

Recreational marijuana sales began in Ohio on August 6. Between that day and September 28, the state’s Division of Cannabis Control reported total sales of $87.1 million. During that period, recreational retailers sold 10,213 pounds of flower and 1,361,146 units of manufactured products.

During the same period, medical marijuana patients purchased $52,047,919 worth of product, bringing the combined total for legal marijuana sales between August 6 and September 28 to $139,171,008.
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Maryland: $97 Million in Marijuana Sold Legally in September, $850 Million So Far in 2024

Maryland marijuana stores sold roughly $97 million worth of product in September.

According to data released by the research firm Headset, there was $97.4 million worth of marijuana and marijuana products sold legally in September. Although this is a drop from the record-breaking $100.6 million sold in August, it marks a nearly 5% increase from sales total from the previous September.

The year-to-date total for marijuana sales in Maryland is now approximately $850 million.
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Poll: Plurality of Voters in North Dakota Support Measure 5 to Legalize Marijuana

According to new polling, a plurality of North Dakota voters support Measure 5 to legalize recreational marijuana for everyone 21 and older, though support falls short of a majority.

The poll, commissioned by the North Dakota News Cooperative and conducted by WPA Intelligence, found that 45% of likely voters support Measure 6, with 40% opposed and 15% undecided. The poll shows a considerably drop in opposition compared to July, when polling showed 43% to be in support and 57% opposed.

Measure 5 was put forth by the group New Economic Frontier. If passed, the proposal would legalize the possession of up to one ounce of marijuana, four grams of marijuana concentrates, and 1,500 milligrams of adult-use cannabinoid products for individuals aged 21 and older. The measure also includes provisions for residents to cultivate up to three marijuana plants for personal use. Additionally, it would establish a regulated market for the sale of marijuana products through licensed retailers.

With Measure 5 on the ballot, North Dakota joins South Dakota and Florida as states considering legalization initiatives this November. If all three are approved by voters, there will be 27 legal marijuana states.

For the full text of Measure 5, click here.

California: $334 Million in Legal Marijuana Sold in September, Over $3.1 Billion So Far in 2024

California marijuana sales saw a slight dip in September compared to August and July, but remained steady with over $330 million in total sales.

Licensed marijuana stores in California sold approximately $334 million worth of marijuana and related products (edibles, concentrates, etc.) in September, according to data from the research firm Headset. This represents a $9 million drop from the $343 million sold in August, and a 7% decline from September 2023.

Year-to-date marijuana sales in California have surpassed $3.1 billion. Recently, the California Department of Tax and Fee Administration reported that the state collected $263.1 million in marijuana tax revenue during the second quarter of this year.

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Federal Government Seeks Contractors to Roll Hundred of Thousands of Marijuana Joints

The National Institute on Drug Abuse (NIDA) has issued a new request for proposals seeking contractors capable of producing hundreds of thousands of marijuana joints.

According to the agency, demand for “marijuana cigarettes” and other controlled substances has surged in recent years, driven by an increase in drug abuse research. Because of this, NIDA is now searching for suppliers that can produce joints in bulk, with a particular emphasis on those able to hand-roll smaller batches with specific levels of delta-9-THC, cannabidiol (CBD), or both, as needed for research purposes.

In NIDA’s 141-page document they mention “sample task orders”, including manufacturing tens of thousands of standardized joints, along with thousands of hand-rolled joints. The THC and CBD concentrations for these samples will be relatively low compared to the legal marijuana market. For example, THC content ranges from 1% to 5%.
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Germany Grants 14 More Licenses for Marijuana Social Clubs

German officials have granted licenses to 14 additional marijuana social clubs across four states.

Germany’s cannabis cultivation social clubs saw continued growth in both applications and licenses throughout September, although the pace has slowed compared to previous months.

Recent data shows that 14 licenses have now been granted across four federal states, as more regions and regulatory bodies refine their application processes.
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