An important new study published in the Journal of Hypertension reveals that long-term treatment with cannabidiol (CBD) can significantly improve cardiovascular health in an animal model of renovascular hypertension.
Conducted by researchers from the Federal University of Paraiba and São Paulo State University in Brazil, the study explores CBD’s potential to lower blood pressure, enhance vascular function, and reduce oxidative stress—offering intriguing new possibilities for treating hypertension and related cardiovascular complications.
While previous studies have shown that acute CBD administration can reduce blood pressure and oxidative stress in hypertensive rats, this study sought to investigate the long-term cardiovascular effects of chronic CBD treatment. Using a well-established 2-kidney-1-clip (2K1C) model, the researchers induced renovascular hypertension in male Wistar rats to assess how sustained CBD treatment affects cardiovascular health over time.
In the study, male Wistar rats underwent either 2K1C or SHAM surgery. Six weeks after the surgeries, the rats received chronic CBD treatment (20 mg/kg) twice a day for 14 days. The researchers employed a range of in vivo, in vitro, and ex vivo methods to thoroughly examine the impact of CBD on the cardiovascular system in hypertensive rats.
The results were compelling: chronic CBD treatment significantly reduced blood pressure in hypertensive rats, particularly in response to the ganglionic blocker hexamethonium. CBD also normalized the variability in low-frequency (LF) power and the ratio of low-frequency to high-frequency (LF/HF) signals, which are key markers of improved baroreflex sensitivity, a critical factor in regulating cardiovascular function.
Additionally, CBD treatment enhanced vasodilation and reduced vasoconstriction in the mesenteric artery, which further improved overall vascular function. A key finding was that CBD treatment reduced levels of reactive oxygen species (ROS) in the aorta, a major contributor to oxidative stress that can damage cardiovascular tissues in hypertensive conditions.
The study also demonstrated that CBD decreased sympathetic nerve activity, which is often heightened in hypertensive states and can lead to increased cardiovascular strain. By improving baroreflex sensitivity, reducing oxidative stress, and enhancing vascular health, chronic CBD treatment showed significant promise in managing renovascular hypertension.
For more information on this study, click here.
