A new study published in the International Journal of Molecular Sciences highlights the potential of phytocannabinoid-based formulations in skincare.
“Recent advancements have highlighted the potential of cannabis and its phytocannabinoids (pCBs) in skin health applications”, begins the study’s abstract. “These compounds, through their interaction with the endocannabinoid system (ECS), show promise for skin health products. Their ability to regulate inflammation, oxidative stress and cell proliferation makes them useful in addressing skin problems such as inflammation, scarring, healing, acne and aging, positioning them as valuable tools for innovative skincare solutions.”
For this study, which was conducted by researchers from the Universidade de Lisboa, “the cellular and molecular effects of proprietary pCB-based formulations on ECS modulation, inflammation and skin regeneration were investigated.”
Using human dermal fibroblasts (HDF) and keratinocytes (HaCaT), the effect of formulations in both pre-treatment and treatment scenarios following exposure to stress-inducing agents was assessed. “Key molecular markers were analyzed to tackle their efficacy in mitigating inflammation and promoting structural integrity and regeneration.”
In vitro results showed that these formulations “significantly reduced inflammation, promoted skin regeneration and improved structural functions.” Researchers say “In vivo studies confirmed that the formulations were well-tolerated and led to noticeable improvements in skin health, including enhanced barrier function.”
Researchers conclude:
This study demonstrates the safety and efficacy of pCB-based formulations for cosmeceutical applications. By combining molecular analysis with in vivo testing, this research provides new insights into the therapeutic potential of pCBs for managing various skin conditions.
