A new study published in the journal Pharmacology Biochemistry and Behavior finds that purified cannabidiol (CBD) may help improve severe, treatment-resistant behavioral symptoms in children with autism spectrum disorder (ASD).
The prospective, observational study included 20 pediatric patients with severe ASD who were unresponsive to conventional medications and behavioral interventions. Researchers examined the efficacy and safety of CBD as an add-on treatment, with evaluations conducted at baseline and every three months over an average follow-up period of 11 months.
Results showed that 90% of participants experienced improvement in at least one symptom after initiating CBD treatment. Among those who responded, 83.5% of reported symptoms improved. Researchers found a 30% improvement in irritability, social withdrawal, and hyperactivity, while restricted and repetitive behaviors improved in 50% of participants. Sleep patterns showed slight improvement.
Adverse effects were reported in over half of patients, primarily increased irritability and decreased appetite, but were classified as mild or moderate and resolved over time. Notably, 40% of participants were able to reduce or partially discontinue other medications.
Researchers conclude:
Our results suggest that treatment with purified CBD is effective and safe and could benefit patients with severe ASD by improving some of the core symptoms, including repetitive behaviors and social interaction, as well as associated comorbidities. The families considered the quality of life to have improved.
