The dynamic landscape of the U.S. cannabis market continues to evolve, including which strains are the most popular among consumers.
Lemon Cherry Gelato.
Using data from state regulatory agencies, the strain review site Leafly, and opinions provided to us by our readers, below is a list of the most popular cannabis strains in the United States, as of April 2025.
Wedding Cake
Known for its calming and euphoric effects, and its sweet and rich flavor profile, Wedding Cake has solidified its status as a standout and highly popular strain. In April, it tops our monthly list for the first time.
Lemon Cherry Gelato
This hybrid has seen a notable rise in popularity in recent months. With its vibrant blend of citrus, berry, and sweet tropical flavors, Lemon Cherry Gelato offers relaxing, anxiety-fighting effects.
Blue Dream
A sativa-dominant hybrid that has maintained its appeal over the years and is a perenial strain on our monthly top-strain lists, Blue Dream is renowned for its sweet berry aroma and balanced effects. It provides an uplifting cerebral buzz followed by gentle full-body relaxation, suitable for both novice and experienced users.
Apple Fritter
Combining sweet apple flavors with a euphoric and calming high, Apple Fritter remains a favorite among consumers. It’s ideal for those seeking relief fro
Apple Fritter.
m discomfort without heavy sedation, allowing users to remain functional while alleviating stress.
Permanent Marker
A newer entrant that has quickly gained traction, Permanent Marker is distinguished by its strong, unique aroma reminiscent of fresh ink, complemented by floral and fuel-like undertones. This hybrid delivers a blend of cerebral euphoria and physical relaxation, appealing to seasoned consumers.
Sour Diesel
A classic sativa-dominant strain, Sour Diesel is celebrated for its pungent, fuel-like scent and invigorating effects. It’s favored by those looking to alleviate stress and fatigue while maintaining motivation and focus.
Gelato
This hybrid continues to please with its dessert-like flavor and harmonious effects. Gelato offers a euphoric yet soothing experience, making it perfect for unwinding without excessive sedation.
Gelato.
Runtz
A cross between Zkittlez and Gelato, Runtz remains a popular choice, offering a euphoric lift followed by a calming body relaxation. Its sweet, candy-like flavor continues to attract a dedicated following.
Ice Cream Cake
This indica-dominant hybrid is gaining popularity for its creamy vanilla flavor and deeply relaxing effects. Ice Cream Cake is often chosen by those seeking assistance with sleep or looking to unwind after a long day.
Jack Herer
Named after the famed cannabis activist, Jack Herer is a sativa-dominant strain known for its earthy pine and citrus flavors. It provides a clear-headed, creative high, making it a favorite for daytime use among those seeking focus and inspiration.
