A new systematic review and network meta-analysis, published in the Journal of Psychopharmacology, explores the potential of psychedelics to alleviate existential distress in terminally ill patients.

Dried psilocybin (left) and LSD (right).
Conducted by researchers from the University of Modena and Reggio Emilia, the Italy Department of Mental Health and Drug Abuse, and the University Utrecht in the Netherlands, the study analyzed data from nine randomized controlled trials (RCTs) involving 606 participants.
The analysis assessed the efficacy and safety of psychedelics such as psilocybin, ketamine, LSD, and MDMA. Results showed significant improvements in depression and anxiety compared to control groups.
“Network meta-analysis identified psilocybin as the most effective compound for depression, and LSD for anxiety. However, head-to-head comparison between psychedelics did not reach statistical significance”, states the study. “The rates of treatment discontinuation and adverse events between psychedelics and controls were comparable.”
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