Study: Combination of THC and CBD Reduces Seizure Frequency in Children with Treatment-Resistant Epilepsy

According to a new study published in the journal Neuropediatrics the daily administration of a combination of THC and CBD is effective in reducing seizures in children with treatment-resistant epilepsy.

For the study researchers from the Imperial College London and Sapphire Medical Clinics examined the efficacy and safety of CBD isolate oils, CBD broad-spectrum oils, and an oil that contained an equal combination of both CBD and THC.

Researchers found that “65.7% of patients achieved a ≥50% reduction in seizure frequency”, while 94.1% of patients treated with CBD and Δ9-THC “observed a ≥50% reduction in seizure frequency”. This is compared to 31.6% and 17.6% of patients treated with CBD isolates and broad-spectrum CBD products respectively.”
Although some adverse effects were recorded, researchers found that “the majority of these were mild and moderate”.

“The results of this study demonstrate a positive signal of improved seizure frequency in children treated with CBMPs for TRE”, concludes the study. “Moreover, the results suggest that CBMPs are well-tolerated in the short term.”

Below is the study’s full abstract:

Abstract

Background There is a paucity of high-quality evidence of the efficacy and safety of cannabis-based medicinal products in treatment of treatment-resistant epilepsy (TRE) in children. Methods A case series of children(<18 years old) with TRE from the UK Medical Cannabis Registry was analysed. Primary outcomes were ≥50% reduction in seizure frequency, changes in the Impact of Paediatric Epilepsy Score(IPES) and incidence of adverse events. Results Thirty-five patients were included in the analysis. Patients were prescribed during their treatment with the following-CBD isolate oils(n=19), CBD broad-spectrum oils(n=17), and CBD/Δ9-THC combination therapy(n=17). Twenty-three(65.7%) patients achieved a ≥50% reduction in seizure frequency. 94.1%(n=16) of patients treated with CBD and Δ9-THC observed a ≥50% reduction in seizure frequency compared to 31.6%(n=6) and 17.6%(n=3) of patients treated with CBD isolates and broad-spectrum CBD products respectively(p<0.001). Twenty-six(74.3%) adverse events were reported by 16 patients(45.7%). The majority of these were mild(n=12; 34.2%) and moderate(n=10; 28.6%). Conclusions The results of this study demonstrate a positive signal of improved seizure frequency in children treated with CBMPs for TRE. Moreover, the results suggest that CBMPs are well-tolerated in the short term. The limitations mean causation cannot be determined in this open-label, case series.

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