A new study published in Molecular Medicine Reports finds that nanoparticles made from Cannabis sativa stems could have serious potential as a cosmetic ingredient.
Conducted by researchers at the Korea Research Institute of Bioscience and Biotechnology and Chungnam National University, the study evaluated the properties of Cannabis sativa stem-derived nanoparticles (CSS-NPs) and their potential use in treating skin disorders. The CSS-NPs, measuring approximately 120 nanometers in diameter, demonstrated resilience to harsh conditions such as fluctuating pH and enzymatic degradation. They also contained 48 distinct biochemical compounds.
In laboratory testing on mouse melanoma cells exposed to α-melanocyte stimulating hormone (α-MSH), which promotes melanin production, CSS-NPs significantly reduced the expression of genes and proteins linked to melanin synthesis. This effect was achieved through the activation of the ERK and Akt signaling pathways—two key regulators of cellular processes. Additionally, the nanoparticles improved cell viability and reduced reactive oxygen species while increasing levels of antioxidant-related enzymes.
The results suggest that CSS-NPs could serve as a multifunctional cosmetic ingredient, helping to reduce hyperpigmentation while boosting the skin’s antioxidant defenses. Researchers conclude that these nanoparticles show strong potential for use in cosmetic products designed to treat pigmentation issues and protect skin cells from oxidative stress.
For more information on this study, click here.
