Study: Cannabinoids Can Reduce the Viability of Human Bladder Cancer Cells

The results of newly published research “indicate that cannabinoids can reduce human bladder transitional cell carcinoma cell viability”.

The research is published in the recent issue of the Journal of Cannabis Research, and it was epublished by the National Library of Medicine. Conducted by researchers at  Dalhousie University in Canada, the study is titled Anticancer properties of cannabidiol and Δ9-tetrahydrocannabinol and synergistic effects with gemcitabine and cisplatin in bladder cancer cell lines.

The study notes that “Several studies have demonstrated anti-tumor effects of components present in cannabis in different models. Unfortunately, little is known about the potential anti-tumoral effects of cannabinoids in bladder cancer and how cannabinoids could potentially synergize with chemotherapeutic agents.” The current study aimed “to identify whether a combination of cannabinoids, like cannabidiol and Δ9-tetrahydrocannabinol, with agents commonly used to treat bladder cancer, such as gemcitabine and cisplatin, can produce desirable synergistic effects. We also evaluated if co-treatment with different cannabinoids resulted in synergistic effects.”
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Tomorrow Oklahoma Voters Decide the Fate of an Initiative to Legalize Marijuana

Tomorrow, March 7, voters in Oklahoma voters will decide the fate of an initiative to legalize recreational marijuana, potentially making their state the 22nd to do so.

State Question 820 is on the March 7 special election ballot, placed there by the state’s governor after the secretary of state missed the signature counting deadline that would have seen the measure voted on in November.

State Question 820 would allow those 21 and older to possess, consume, cultivate and purchase marijuana for any purpose, be it medical, recreational or therapeutical. The possession limit would be set at one ounce of marijuana, eight grams of marijuana concentrates and eight grams of marijuana-infused products. The cultivation limit would be set at six mature plants and six seedlings.
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Legislation to Legalize Marijuana Filed in Florida

Florida State Senator Victor Torre has filed a legislative proposal that would legalize recreational marijuana for everyone 21 and older.

Senate Bill 1576 would make the personal possession of up to 2.5 ounces of marijuana legal in Florida for everyone 21 and older, while also allowing them to grow up to six marijuana plants. The measure would also establish a “Division of Cannabis Management” in the Florida Department of Agriculture and Consumer Services that would be in charge of overseeing the legal marijuana market.

The law would not legalize the public consumption of marijuana, but as with many other legal marijuana states this would not be an arrestable offense but instead would be an $100 ticket.
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Study Finds Marijuana Extracts With Equal Parts THC and CBD Could Potentially Treat Melanoma

The use of cannabis-derived extracts containing equal amounts of THC and CBD is a potential treatment option for those with melanoma, finds a study published by the journal Anticancer Research.

Malignant melanoma is an aggressive skin cancer, accounting for the majority of skin cancer deaths. The study notes that prognosis is often poor and finding effective treatment remains a challenge. In this study researchers “aimed to perform gene expression analysis of human melanoma A375 cells following stimulation with C. sativa extracts.”

For the study, which was conducted by researchers at Mae Fah Luang University, the Ministry of Public Health, the Government Pharmaceutical Organization, Mahidol University and the Institute of Medical Research and Technology Assessment, all in Thailand, “Gene expression profiles of A375 human melanoma and Vero (control) cell lines were evaluated by RNA sequencing and quantitative real-time PCR.”
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Hawaii Bill to Legalize Marijuana Passed by Two Senate Committees

Legislation to legalize marijuana has been overwhelmingly approved by two committees in the Hawaii Senate.

Senate Bill 669 was passed today by the Senate Ways and Means Committee by a vote of 10 to 2, the same day it passed the Senate Commerce and Consumer Protection Committee in a unanimous 4 to 0 vote.

“Today marks a significant step forward in the legalization of adult-use cannabis in Hawai”, said Senator Jarrett Keohokalole, one of the bill’s cosponsors. “These amendments are reflective of the Senate’s commitment to ensuring a fair and well-regulated cannabis market that provides safe access to both adult consumers and existing medical patients.”
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Study: Marijuana Legalization Associated With Reduction in Pedestrian Fatalities

Legalizing marijuana is associated with a reduction in the number of alcohol-related fatalities involving pedestrians, according to a new study published in the journal IATSS (International Association of Traffic and Safety Sciences) Research.

For the study researchers from Florida Polytechnic University examined the relationship between marijuana legalization and rates of pedestrian-involved fatal crashes between the years 1985 and 2019. This is particularly important because “Pedestrian fatality rates in the US began to increase in 2009, after three decades of decline.”

Researchers found that the passage of both medical cannabis laws and laws legalizing recreational marijuana were associated with overall declines in pedestrian fatalities, including declines in alcohol-related fatalities. Researchers believe this may be due to consumers substituting marijuana for alcohol.
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North Carolina Senate Votes 36 to 10 to Pass Medical Marijuana Bill

Legislation to legalize medical marijuana in North Carolina has been passed by the state’s full Senate.

By a vote of 36 to 10 the North Carolina Senate passed legislation that would narrowly legalize medical marijuana for those with certain medical conditions. Introduced by Senator Bill Rabon with a bipartisan coalition of 12 cosponsors, the measure now goes to the House of Representative. Passage in the House would send the bill to Governor Roy Cooper for final consideration.

Under  (the “Compassionate Care Act”) patients with a “debilitating medical condition” such as cancer, epilepsy, HIV/AIDS, Parkinson’s disease, multiple sclerosis and post-traumatic stress disorder would be allowed to possess and consume medical marijuana and marijuana products if they receive a recommendation from a licensed physician, who would need to reevaluate patients’ medical marijuana status annually.
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Seventh Minnesota Senate Committee Approves Bill to Legalize Marijuana

The Senate Human Services Committee in Minnesota has given approval to a measure that would legalize recreational marijuana for everyone 21 and older.

The measure (SF 73) has now been passed by seven Senate committees. A companion bill (HF 100) has been approved by 10 committees in the House of Representatives. The proposed legislation would allow those 21 and older to possess up to two ounces of marijuana and grow up to eight plants for personal use, in addition to establishing a regulatory framework for licensed retail marijuana outlets.

“This allows adults to safely and responsibly use cannabis,” said Senator Clare Oumou Verbeten, who spoke to the committee on behalf of the bill’s sponsor Senator Lindsey Port. “It creates a regulated marketplace that’s much safer than our current underground illicit marketplace.” She said that marijuana prohibition “has caused immense harm in our communities, and that’s particularly when it comes to the criminal justice system”.
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A New Study “Demonstrated that Cannabidiol is a Viable Therapy to Treat Prostate Cancer Cells”

A study published in the peer-reviewed journal Molecular Biology Reports has “demonstrated that cannabidiol is a viable therapy to treat prostate cancer cells”.

Prostate cancer is the second most frequently occurring carcinoma in males worldwide and one of the leading causes of death in men around the world, states the study which was conducted by researchers at the Department of Biochemistry at the University of Johannesburg in South Africa. Recent studies estimate that over 1.4 million males are diagnosed with prostate cancer on an annual basis, with approximately 375,000 succumbing to the disease annually.

With current treatments “continuing to show severe side effects”, researchers say there is a need for new treatments. In this study they “looked at the effect of cannabis sativa extract, cannabidiol and cisplatin on prostate cancer cells, PC3.”
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Four Michigan Cities Have Passed Ordinances to Decriminalize Psychedelics

Ferndale has become the fourth city in Michigan to locally decriminalize the possession of psychedelics such as magic mushrooms.

The Ferndale City Council passed a resolution this week that effectively decriminalizes certain psychedelics including psilocybin (“magic mushrooms”), DMT and ayahuasca by making it the lowest enforcement priority. This makes Ferndale the fourth Michigan city to make such a move, followed by Ann Arbor, Detroit and Hazel Park.

“[T]he Mayor and City Council hereby declare that it shall be the policy of the City of Ferndale that the investigation and arrest of persons for planting, cultivating, purchasing, transporting, distributing, engaging in practices with, or possessing Entheogenic Plants or plant compounds which are on the Federal Schedule 1 list shall be the lowest law enforcement priority for the City of Ferndale, and city funds or resources shall be prioritized for other City of Ferndale functions”, states the resolution.
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