A study published recently in the peer reviewed journal Molecular Psychiatry found that psilocybin, a psychedelic compound, may help reduce heroin-seeking behavior.
Researchers from Temple University conducted experiments to investigate the potential therapeutic effects of psilocybin on opioid addiction, particularly focusing on relapse behavior following heroin self-administration.
In the study, rats were given heroin at 0.075 mg/kg/infusion, followed by a period of forced abstinence. Psilocybin, along with 5-HT2A receptor antagonists ketanserin and volinanserin, was administered to test its impact on heroin-seeking behavior. The researchers found that while psilocybin did not reduce heroin intake, a single dose of 3.0 mg/kg significantly reduced cue-induced heroin-seeking behavior four to 24 hours after administration. On the other hand, the 5-HT2A receptor antagonists exacerbated heroin relapse.
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