According to the results of a new study published in Inflammopharmacology, full-spectrum cannabis sativa extract (FSC) may offer significant benefits in protecting the gut and peripheral organs following an ischemic stroke.
Researchers from Brazil, Canada, and the United States examined the effects of FSC on male Wistar rats that underwent a 60-minute middle cerebral artery occlusion, a common model for stroke. The animals received doses of FSC (15 or 30 mg/kg) or a control oil at various intervals following the stroke. After 72 hours, researchers measured neurological performance, organ weights, blood markers, hormone levels, intestinal permeability, oxidative stress, and inflammation.
The study found that FSC significantly improved neurological scores, suggesting therapeutic potential for post-stroke recovery. Treated rats also showed reduced intestinal permeability, decreased inflammation in the lungs, and lower levels of oxidative stress. Additionally, there was a reduction in body mass and blood cell counts related to immune response, as well as atrophy in certain lymphoid organs such as the spleen and thymus. Serum corticosterone levels—a stress hormone—were also lower in the FSC group.
Researchers say these findings point to a protective role for full-spectrum cannabis extract not just in brain recovery, but also in preventing damage to other organs affected by stroke. The results support further exploration into cannabis-based therapies for neurodegenerative conditions and post-stroke rehabilitation.
Researchers conclude the study by stating:
The discovery of the positive impacts of FSC in this study represents an entry point for new explorations and perspectives within this field. With latent potential, these findings have the power to shape clinical research, especially in the realm of neurodegenerative diseases and innovative therapies. Therefore, the results highlight the promising role of FSC, paving the way for more effective and transformative clinical interventions.
