Study: CBD Reduces Seizures That Are Resistant to Common Medications

A new study has found that CBD reduces seizures in patients with Dravet syndrome (SD), Lennox-Gataut syndrome (LGS), or tuberous sclerosis complex (TSC), who are resistant to common medications.

Published by the journal Revista da Associação Médica Brasileira and epublished by the National Library of Medicine, the study was conducted by researchers at Medicina Baseada em Evidências and Faculdade de Medicina, both in Brasil.

According to its abstract, the objective of this “systematic review with meta-analysis was to evaluate the efficacy, safety, and short- and long-term tolerability of cannabidiol (CBD), as an adjunct treatment, in children and adults with Dravet syndrome (SD), Lennox-Gataut syndrome (LGS), or tuberous sclerosis complex (TSC), with inadequate control of seizures.”
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Report: Global Cannabis Cultivation Market Worth $132 Billion, to Grow to $235 Billion by 2026

According to a new Cannabis Cultivation Global Market Report 2022, the market is expected to grow from $114.66 billion in 2021 to $132.55 billion in 2022.

The report found that this number will grow drastically in the coming years, with estimates putting the market’s value at $235.74 billion by 2026, an over $100 billion increase in four years.

According to the report, the major players in the market are Pacific Cannabis Growers Inc, Atlas Growers, Canntrust Holdings Inc, The Hydropothecary Corporation, Better Holdings, Canopy Growth Corporation, Aphria Inc, Aurora Cannabis, Tilray, Organigram Holdings Inc, The Cronos Group, Maricann Group Inc, ABcann Medicinals Inc, GW Pharmaceuticals plc, and Vivo Cannabis Inc.
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CA$389.9 million in Legal Marijuana Sold in September in Canada

New Canada sales data shows that there was $389.9 million in legal marijuana sold in September, a 12% increase from September, 2021.

The 389.9 million Canadian dollars ($291 million) worth of legal marijuana sold in September exactly matches the amount of legal marijuana and marijuana products sold in August, according to the national data agency Statistics Canada.

In Ontario, the largest provincial market in Canada, marijuana sales grew 1.1% month-over-month to CA$155.5 million in September. In Alberta, the second largest market in the country, sales increased 2% on a monthly basis to CA$68.7 million. British Columbia’s September sales were up by 0.6% over August, to CA$59.4 million.

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Pew Research Poll: 88% of Americans Say Marijuana Should be Legal for At Least Medical Purposes

A drastic majority of adults in the U.S. believe marijuana should be legal for medical and/or recreational purposes.

According to a new Pew Research poll, an overwhelming share of U.S. adults (89%) say either that marijuana should be legal for medical and recreational use by adults (59%) or that it should be legal for medical use only (30%). Just one-in-ten (10%) say marijuana use should not be legal, according to the survey conducted Oct. 10-16, 2022. These views are virtually unchanged since April 2021, notes Pew.

The Pew poll shows support for legalizing recreational marijuana nine percent lower than a Gallup poll released last week which shows support for legalization at 68%.
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Legal Recreational Marijuana Sales Begin in Rhode Island on December 1

Rhode Island Governor Dan McKee announced this morning that five licensed medical marijuana compassion centers have received state approval to begin selling recreational marijuana on or after December 1.

These five outlets will be the first in the state to legally sell recreational marijuana to those 21 and older. The licenses are being issued pursuant to the Rhode Island Cannabis Act, which was passed by the General Assembly and signed into law by Governor McKee in May. The law called for applications for “hybrid retail licenses,” which allow licensed compassion centers to sell both medical marijuana as well as safe, well-regulated and competitively priced marijuana products to Rhode Island adults over the age of 21. Licenses were issued in early October

As of this morning, the five compassion centers that have received state approval to commence adult use sales are:

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Oregon Governor Announces Pardon of Over 45,000 Marijuana Convictions

Oregon Governor Kate Brown announced today that she has issued pardons to everyone caught possessing up to an ounce of marijuana prior to its legalization in 2016.

The pardons will remove 47,144 convictions for possession of a small amount of marijuana from individual records, eliminating barriers for thousands of people seeking employment, housing, and educational opportunities who have otherwise been ineligible. It will also forgive more than $14,000,000 in associated fines and fees.

The pardon applies to electronically available Oregon convictions for possession of 1 ounce or less of marijuana, in pre-2016 cases in which the person was 21 years of age or older, where this was the only charge, and where there were no victims, according to a press release. This pardon does not apply to any other offense related to marijuana or other controlled substances. More information can be found here.
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Study: Cannabinoids May Induce Immunogenic Cancer Cell Death

Cannabinoids may induce immunogenic cell death indicating they may be useful in combatting cancer.

This is according to a new study being published in the upcoming issue of the peer-reviewed journal Cannabis and Cannabinoids Research. The study was epublished by the National Institute of Health, and “is the first demonstration that cannabinoids can induce the cell surface expression of ectoCRT, and potentially induce ICD [immunogenic cell death].”

Endogenous and synthetic cannabinoids “have been shown to induce cancer cell death through the accumulation of the sphingolipid, ceramide (Cer)”, states the study. “Recently, we have demonstrated that Cer accumulation enhances the induction of immunogenic cell death (ICD).”
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Study: Oral Cannabinoid Therapy Safe and Effective Against Treatment Refractory Chronic Pain

Oral cannabinoid therapy seems to be safe and at least mildly effective in patients with treatment refractory chronic pain, according to a new European Journal of Pain study.

“Cannabinoids are considered a therapeutic option to patients suffering from treatment refractory chronic pain (TRCP) insufficiently relieved by conventional analgesics or experiencing intolerable adverse events (AEs) from those”, the abstract states. “This study aimed to explore safety and effectiveness of oral cannabinoids among patients with TRCP.”

A retrospective study was conducted among Danish patients with TRCP being prescribed oral cannabinoids. Data on AEs and changes in pain intensity by numeric rating scale (NRS) before and after initiation of oral cannabinoid therapy were analyzed. The study was conducted by researchers at the Horsted Institute, North Denmark Regional Hospital and Aalborg University, all in Denmark.
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Gallup Poll: 68% of Americans Want Legal Marijuana, Including Majority of All Age Groups

Support for marijuana legalization in the U.S. remains at the record-high 68% recorded in each of the past two years according to a new Gallup Poll.

When Gallup first asked about legalizing marijuana in 1969, just 12% of Americans were in favor. Support grew steadily to 2000, when just about one third (31%) said they want marijuana legalized. Support surpassed the majority level in 2013, and since 2016 at least six in 10 have been in favor.

The new poll is based on thousands of participants who were questioned between October 3 and October 20.
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President Biden Will Sign Marijuana and Cannabidiol Research Act Into Law

On Wednesday the U.S. Senate passed the Medical Marijuana and Cannabidiol Research Expansion Act, making it the first standalone piece of marijuana legislation to ever reach the president’s desk. Now the White House says President Biden will soon sign it into law.

H.R. 8454 passed the Senate on Wednesday and passed the House of Representatives in July. Now, Press Secretary Karine Jean-Pierre tells us that President Biden will “soon sign the measure into law.”

The bill is designed to facilitate research on marijuana and its potential health benefits, which up until this point has been a challenge for researchers. The bill will accomplish this by streamlining the application process for scientific marijuana studies and removing existing barriers for researchers that frequently slow the research process. The measure will also make it so that it’s not a violation of the Controlled Substances Act for a State-licensed physician to discuss the health benefits of medical marijuana.

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