Six Marijuana-Related Clinical Trials Now Open for Participants at UC San Diego

The University of California San Diego (UCSD) is seeking participants for six marijuana-related clinical trials.

The university is currently conducting seven clinical trials related to marijuana and its compounds, with all but one currently open to new participants (the seventh is “currently not accepting new patients, but might later”). Below is a breakdown of these trials, with summaries of what researchers are seeking to accomplish and links for those interested in taking part.
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UCSF Seeks Participants for Four Psilocybin Clinical Trials

The University of California San Francisco (UCSF) is seeking participants for four clinical trials exploring the effects of psilocybin on mental health conditions and chronic low back pain.

The university is currently conducted eight clinical trial related to psilocybin, with two “in progress, not accepting new patients”, two that are “not yet accepting patients”, and four that are currently “open to eligible people”.

Below is a summary of the four trials that are currently seeking participants, with links for those interested in contacting the university to apply or to seek further information.
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Study: Recreational Marijuana Legalization Linked to Reduction in Opioid Deaths

A new study reveals that legalizing recreational marijuana may cut opioid-related deaths by an average of 3.5 per 100,000 residents.

The research, based on state-level data from the U.S. Centers for Disease Control and Prevention, found the most significant impact in states that legalized marijuana earlier in the opioid crisis. According to the study, the decline in overdose deaths was immediate in these states and grew stronger over time, persisting for at least five years.

Researchers from multiple institutions, including Texas Tech University, New Mexico State University, and the American Institute for Economic Research, observed similar trends in states that legalized marijuana more recently, though the effects typically appeared three years after legalization, coinciding with the development of dispensary infrastructure.
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Study: 3D-Printed CBD Suppositories Show Promise in Treating Epilepsy

Researchers from the Beijing Institute of Radiation Medicine have found that cannabidiol (CBD)-loaded hollow suppositories using 3D printing technology may be effective in treating epilepsy.

3D-printed CBD suppository.

Published in the International Journal of Pharmaceutics, the study highlights the limitations of traditional oral CBD formulations, which often face significant first-pass metabolic effects, reducing their efficacy. The newly designed suppository, referred to as CHS (cannabidiol-loaded hollow suppository), features an inner supporting spring and an outer CBD-loaded hollow shell.

The spring was created using 3D-printed thermoplastic urethane filaments, while the shell was crafted with a metal mold filled with a mixture of CBD, polyvinyl alcohol, and polyethylene glycol. Laboratory tests showed that CHS provided a sustained release of CBD over five hours, allowing effective systemic delivery.
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Florida Medical Marijuana Sales Top $155 Million in November, Nearly $1.7 Billion So Far in 2024

Florida’s medical marijuana industry remains strong, with $155.4 million in sales reported for November.

This figure, provided by the research firm Headset, represents a 26% increase from the $122.6 million recorded in October. Year-to-date sales have reached approximately $1.67 billion, with March leading the way at $173 million.

Dried marijuana flower remained by far the most popular category of medical marijuana purchases in November, followed by vape pens, edibles, concentrates, tinctures, capsules, and topicals.
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Arkansas: $24 Million in Medical Marijuana Sold in November, Over $250 Million Year-to-Date

Medical marijuana sales in Arkansas remained strong in November.

According to data released by the Arkansas Department of Finance and Administration, there was $24 million worth of medical marijuana sold in November, despite the state having just 37 dispensaries. This comes out to an average of around $650,000 per dispensary.

The year-to-date total for marijuana sales is now $251.9 million, roughly on part with but slightly less than the $258 million sold between January and November 2023.
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The States Most Likely to Legalize Marijuana in 2025

24 states have legalized recreational marijuana, but that number is poised to grow in 2025.

In 2025, several states are on track to put forth serious efforts to become the 25th legal marijuana state. Below is a list of the four most likely to do so, based on the current political climate and ongoing legislative efforts.
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Marijuana Indicas: 2024’s Most Popular Strains

Indicas are renowned for their deeply relaxing effects, often making them a go-to choice for winding down in the evening or managing stress and pain. Here we take a look at the most popular indicas throughout 2024.

Runtz.

In 2024, throughout the states that allow legal marijuana sales, the 10 indicas listed below standout among the hundreds of options as the most popular throughout the United States. This was determined by using data provided by state regulatory agencies and Leafly. You can find a list of 2024’s most popular sativas by clicking here.
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Ascend Wellness Holdings Inc. Announces Share Buyback Program

Ascend Wellness Holdings, Inc., a vertically integrated multi-state cannabis operator focused on bettering lives through cannabis, has announced it’s received authorization from the Company’s Board of Directors to commence a share buyback program.

Pursuant to a normal course issuer bid (“NCIB”) commencing on January 2, 2025, the Company may repurchase up to the lesser of: (i) 10,215,690 shares of the Company’s class A common stock (“Common Shares”), representing approximately 5.0% of AWH’s outstanding Common Shares; and (ii) US$2.25 million worth of Common Shares, in the open market. As of December 24, 2024, there were a total of 204,313,808 issued and outstanding Common Shares.

“With the initiation of this share buyback program, we are taking another meaningful step to continue to create shareholder value,” said Sam Brill, Chief Executive Officer. “Our prior share repurchase, together with the recent open market purchases by members of our board of directors, demonstrate our strong confidence in our strategy and our commitment to driving returns for our investors. With our strong foundation and the impact of our ongoing initiatives, we are excited about the opportunities the new year will bring.”
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Study Validates New Method for Reliable Cannabinoid Quantification in Veterinary CBD Oils, Finds Labels Accurately Reflect Cannabinoid Levels

A study published in the journal Pharmacy has validated a new method for accurately quantifying cannabinoids in commercial veterinary CBD oil.

(Photo credit: Healthline).

According to its abstract, the study “highlights the need for quality control in evaluating medicinal plant products, especially CBD oils, before market release”, noting that “Due to varying regulatory requirements, product labeling can sometimes be misleading, especially regarding cannabinoid concentrations such as CBD and THC.”

With that in mind, this research “focused on developing a validated high-performance liquid chromatography (HPLC) method for accurately identifying and quantifying key cannabinoids in Commercial Veterinary CBD Oil.”
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