A new study published in the journal Brain Research provides evidence that chronic use of a lipid-based cannabidiol (CBD) nanoemulsion may help reduce anxiety and panic-like behavior by targeting brain areas involved in emotional regulation.
Conducted by researchers from the Universidade Federal do Ceará and Universidade Federal de São Paulo in Brazil, the study evaluated both the behavioral and neurological effects of orally administered CBD nanoemulsions in an animal model (rats). The CBD was given either acutely or chronically over a 21-day period at doses of 2.5 or 5 milligrams per kilogram of body weight.
Researchers used the elevated T-maze test to assess anxiety- and panic-like behavior, along with open field testing. They also measured brain CBD concentrations and examined changes in neural activity and serotonin regulation by analyzing markers such as FosB/deltaFosB and tryptophan hydroxylase.
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