Mitragyna parvifolia leaves may serve as a therapeutic agent for lymphatic filariasis, according to a new study conducted by researchers from Madurai Kamaraj University and the Central University of Tamil Nadu in India.
Mitragyna parvifolia.
The study, published in the Journal of Parasitic Diseases, highlights the plant’s diverse bioactivity and underscores its potential for further research as a treatment for this parasitic disease. Mitragyna parvifolia is a relative of kratom, a plant used for thousands of years for its medicinal properties.
Phytochemical analysis of the methanolic leaf extract identified alkaloids, terpenoids, phenols, tannins, and flavonoids, with 24 phytoconstituents confirmed through GC-MS analysis. The primary alkaloid, mitraphylline, was highlighted for its bioactive potential. Functional group analysis using infrared spectroscopy further validated the presence of these compounds.
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The research, conducted by teams from Walailak University in Thailand, the University of Kentucky, and the University of Chittagong in Bangladesh, employed network pharmacology, molecular docking, and in vitro methods to explore the plant’s therapeutic mechanisms.
