Study: CBD, THC, and the Terpene Humulene Show Synergistic Anticancer Effects in Breast Cancer Models

A study in Frontiers in Pharmacology found that cannabinoids can suppress cancer growth and inflammation, as shown through lab tests, animal studies, and computer modeling.

Researchers examined the ethanol extract of female cannabis, which contained cannabidiol (CBD), tetrahydrocannabinol (THC), and humulene, as identified through GC-MS analysis. In vitro testing on cancer cells showed that the extract significantly slowed their growth, killing 51%–77.6% of them. Further analysis found that CBD, THC, and humulene interacted with key proteins linked to cancer progression, including PD-1/PD-L1, TNF-α, and MMP-9.

In vivo, researchers induced breast cancer in female rats using 7,12-dimethylbenz(a)anthracene (DMBA) and treated them with cannabinoids either individually or in combination. Results showed that the simultaneous use of all three cannabinoids produced the most substantial anticancer and anti-inflammatory effects, leading to significant tumor reduction. The treated groups exhibited decreased serum biomarkers associated with inflammation and tumor progression, highlighting the potential of cannabinoids in breast cancer therapy.
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Kentucky Bill to Legalize Marijuana Cultivation for Patients and Expand List of Qualifying Conditions Receives Committee Assignment

Kentucky House Bill 571, a measure to significantly expand the state’s medical marijuana program, has been assigned to the House Health Services Committee.

Ripe bud | Marijuana flower isolated on black with glistening trichromes

HB 571 was filed earlier this month by State Representative Alan Gentry (D) and placed in the House Committee on Committees. Yesterday, the bill advanced to the Health Services Committee.

The proposed law would allow medical marijuana patients or their caregiver to cultivate up to three mature plants and three seedlings at a private residence. The law allows patients to patient any amount of cannabis grown from these plants, but it prohibits patients and caregivers from selling or giving marijuana plants or products to anyone else.
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Top Cannabis Strains for Depression

With depression affecting millions worldwide, here are some of the best cannabis strains for those seeking relief.

Green Crack.

According to the National Institute of Mental Health, there are 21 million people in the U.S. suffering from depression, with the World Health Organization putting the global number at nearly 300 million. Many individuals suffering from depression have found relief in cannabis, with certain strains reputed to alleviate  symptoms more effective than others.

With that in mind, below is a list of the top ten cannabis strains for combatting depression, according to data provided by our readers and the cannabis review site Leafly.

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Study: Psilocin “Exhibits Significant Therapeutic Potential in the Treatment of Epilepsy”

A study being published in the journal Pharmacology Research & Perspectives found that psilocin, the active metabolite of psilocybin, “exhibits significant therapeutic potential in the treatment of epilepsy.”

Psilocybin mushrooms.

Psilocybin mushrooms.

Researchers from Tehran University of Medical Sciences, Iran University of Medical Sciences, and Tarbiat Modares University conducted experiments using mouse seizure models to evaluate psilocin’s effects. The study utilized the pentylenetetrazole (PTZ) test for clonic seizures and the maximal electroshock (MES) test for generalized tonic-clonic seizures, alongside electrophysiological recordings to assess neuronal activity.

The findings indicate that psilocin at a moderate dose (3 mg/kg, i.p.) exhibited anticonvulsant effects. The involvement of various biological pathways was tested using specific inhibitors and receptor modulators. The administration of 1-MT, L-NAME, naltrexone, sildenafil, and AM-251 reduced psilocin’s anticonvulsant effects, highlighting the roles of the kynurenine pathway, opioidergic and nitrergic systems, cGMP signaling, and CB1 receptor activity.

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West Virginia Lawmakers Introduce Constitutional Amendment to Legalize Marijuana

Today, Delegate Sean Hornbuckle (D-Cabell) introduced House Joint Resolution 27 to the West Virginia Legislature, which would place a proposal to amend the state constitution to legalize cannabis on the 2026 general election ballot.

The resolution, co-sponsored by Delegates Lewis, Pushkin, Hansen, and Garcia, has been referred to the Judiciary Committee for further deliberation.

HJR 27 proposes the legalization of up to two ounces of cannabis and the personal cultivation of up to four cannabis plants. Additionally, the resolution empowers the Legislature to enact laws governing the lawful sale and manufacturing of cannabis within the state.
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South Dakota Governor Signs Kratom Bill Into Law

South Dakota Governor Kristi Noem has signed House Bill 1056 into law, officially establishing statewide regulations on kratom products.

Kratom products.

The bill, which passed the House of Representatives in January with a unanimous 66 to 0 vote and cleared the Senate on February 13, also unanimously (35 to 0), introduces restrictions on kratom sales and distribution while setting penalties for violations.

The new law limits the concentration of 7-hydroxymitragynine, a key kratom alkaloid, to no more than two percent. It also bans synthetic derivatives and products containing substances or additives. Additionally, kratom products must now carry detailed labeling, including alkaloid content, as well as warning labels advising against use by pregnant or nursing women.
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Arizona: $26 Million in Marijuana Taxes Garnered in January 2025, Most Since January 2024

Arizona’s marijuana industry generated over $26 million in tax revenue in January.

There was $26,010,976 in tax revenue generated from licensed marijuana sales in January, according to the Arizona Department of Revenue. This is a notable increase over the $23.3 million garnered in December and the $23.7 million in November. January’s taxes brings the all-time total to $1,066,837,757.

In January, $16,770,312 of the taxes made came from the state’s 16% recreational marijuana excise tax, $7,696,300 from the 5.6% adult-use tax, and $1,533,049 from medical marijuana tax revenue. January marked the 38th consecutive month of marijuana tax revenue exceeding $20 million.
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WA Bill to Revise Marijuana Advertising Laws Passes Second Senate Committee, Advances to Full Senate

Senate Bill 5206 has cleared another legislative hurdle, passing the Senate Ways and Means Committee yesterday after previously being approved by the Senate Committee on Labor and Commerce. The bill now advances to the full Senate for a vote.

Sponsored by Senators Drew MacEwen (R), Chris Gildon (R), and Derek Stanford (D), the legislation would modify Washington’s marijuana advertising regulations by expanding signage allowances for licensed retailers.

If enacted, SB 5206 would increase the number of exterior signs marijuana retailers can display from two to four. These signs must be attached to the building or placed in windows, with each limited to 1,600 square inches. Smaller signs under 512 square inches that do not include branding, such as those indicating store hours or ATM availability, would be exempt from advertising regulations.
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New York Governor Proposes Reinstating Marijuana Odor as Evidence for Impaired Driving Tests, Facing Opposition From Legalization Advocates

Governor Kathy Hochul has introduced a proposal to reintroduce the smell of cannabis as a factor in determining reasonable cause for ordering blood tests in impaired driving cases.

New York Governor Catchy Hochul (photo credit: Dia Dipasupil/Getty Images).

New York’s recreational marijuana law, signed in 2021, explicitly barred police from using the odor of marijuana as justification for a traffic stop or vehicle search. Hochul’s proposal would amend that provision to allow law enforcement to cite “the odor of cannabis, burnt cannabis or other drug” as a reason to compel a court-ordered blood test if a driver is suspected of being impaired or involved in a crash.

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Idaho Governor Signs Legislation Establishing Mandatory Minimum Fine for Marijuana Possession

Idaho Governor Brad Little signed House Bill 7 into law today, officially establishing a mandatory minimum fine for marijuana possession.

The measure, which previously passed the state Senate in a 27 to 8 vote after clearing the House 54 to 14, takes away judicial discretion to issue fines below a set amount.

Under Idaho’s existing law, possession of less than three ounces of marijuana is classified as a misdemeanor, carrying fines of up to $1,000. However, there has been no mandatory minimum penalty. With the governor’s signature, House Bill 7 changes that by setting a minimum fine of $300, ensuring that anyone convicted of possession will face at least that amount.

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