A study published in Food & Function finds that compounds extracted from hemp seeds may offer a natural way to combat obesity by targeting key metabolic pathways.
Researchers from the University of Georgia, along with teams from several South Korean universities, examined the unsaponifiable matter derived from hemp seed (HUSM) and found it rich in fat-soluble phytochemicals, including carotenoids, vitamin E, phytosterols, policosanols, and cannabidiol (CBD), with only trace levels of THC.
In cell-based experiments, HUSM significantly reduced lipid accumulation in fat cells, cutting buildup by up to 79% without signs of toxicity. Animal models showed similar benefits, with treatment leading to smaller abdominal size, reduced body weight gain, decreased fat and liver mass, and lower triglycerides, total cholesterol, and LDL cholesterol.
These effects were linked to the activation of the AMPK signaling pathway, which plays a central role in regulating fat storage and metabolism.
The study also found that HUSM helped restore balance in adipokines, lowering leptin while increasing adiponectin, both of which are important markers of healthy fat tissue.
Researchers say the findings highlight hemp seed’s potential as a functional food ingredient and a possible therapeutic option for preventing and managing obesity and related metabolic disorders.
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