Researchers say they have validated an Electronic REference To access In vivo Concentrations (ERETIC)-based method for rapidly and simultaneously measuring five major cannabinoids in marijuana extracts without derivatization or physical reference standards. The study, published in Magnetic Resonance in Chemistry, established a quantitative proton nuclear magnetic resonance (¹H-NMR) method for analyzing tetrahydrocannabinolic acid (THCA), cannabidiolic …
Category: Cannabinoid Studies
Research and studies on minor cannabinoids like CBG, CBN, THCV and others, covering their potential effects, medical uses and scientific findings.
Review Finds Nanoencapsulation Could Improve Cannabinoid-Based Pain Treatments
Encapsulating cannabinoids in lipid nanoparticles may improve their stability, absorption and pain-relieving effects, according to a new review published in the journal Pharmaceutics. Researchers from the Federal University of Rio Grande do Norte and the Federal University of Uberlândia in Brazil reviewed the available evidence on nanoencapsulated cannabinoids, particularly cannabidiol (CBD), for managing acute, chronic …
THCV and CBD Reduce Voluntary Alcohol Consumption in Long-Term Animal Study
Tetrahydrocannabivarin (THCV) and cannabidiol (CBD) both reduced voluntary alcohol consumption among male rats with a long history of drinking, according to a new long-term animal study from Vilnius University. The research examined whether the two cannabis compounds affect different components of alcohol consumption, including the motivation to begin drinking and the reinforcing effects that encourage …
Study Finds CBD, CBG and CBN Suppress Bile Duct Cancer Cells and Trigger Cell Death
According to a study published in the journal Molecules, Cannabidiol (CBD), cannabigerol (CBG) and cannabinol (CBN) may have anticancer effects against cholangiocarcinoma, an aggressive form of bile duct cancer. Researchers from Srinakharinwirot University and Kasetsart University examined the effects of the three cannabinoids on two human cholangiocarcinoma cell lines. They found that all three compounds …
Study Finds CBG Improves Kidney Lipid Metabolism Following a High-Fat, High-Sugar Diet
Cannabigerol (CBG) may help protect the kidneys from early damage caused by diets high in fat and sugar, according to a new study. Researchers examined the effects of CBG on kidney lipid metabolism in male Wistar rats fed a high-fat, high-sucrose diet for six weeks. Such diets are associated with obesity, type 2 diabetes and …
Review Explores How CB1 Signaling Connects Stress, Sleep and Eating Behavior
The endocannabinoid system, particularly CB1 receptor signaling, may serve as a biological link connecting stress, sleep, appetite and energy metabolism, according to a review published in Neuroscience & Biobehavioral Reviews. Researchers from the Federal University of Santa Catarina, Santa Úrsula University, the Federal University of Rio Grande do Norte, the São Paulo Association of Cannabinoid …
CBDA-Rich Cannabis Extract More Strongly Inhibits Epilepsy-Linked Sodium Channels Than Purified CBDA
A cannabis extract rich in cannabidiolic acid produced substantially stronger inhibition of sodium channels associated with epilepsy than purified CBDA alone, according to a laboratory study published by Phytomedicine. The research was conducted by scientists from the National University of La Plata, Argentina’s National Scientific and Technical Research Council and the Scientific Research Commission of …
Oral CBG Safe and Well-Tolerated at Doses Up to 200 Milligrams in Human Study
Cannabigerol was well-tolerated and produced few noticeable effects when administered to healthy adults at doses ranging from 25 to 200 milligrams, according to a new study published by The Journal of Pharmacology and Experimental Therapeutics. Researchers from the Johns Hopkins University School of Medicine, University of Maryland, University of Colorado and University of Virginia School …
Study: CBD-Loaded Nanoparticles Show Promise as Potential Alzheimer’s Treatment
A study published online today by Biomedicine & Pharmacotherapy found that a specialized cannabidiol (CBD) nanoparticle formulation significantly improved memory, reduced brain inflammation, and slowed key markers of Alzheimer’s disease in animal and laboratory models. The study was conducted by researchers from Thammasat University, Mahidol University, Siam University and Kasetsart University in Thailand. Researchers developed …
Study: Cannabinoids and Melatonin May Help Cisplatin Fight Bone Cancer Cells While Allowing Lower Doses
A new study reports that cannabinoids, when combined with melatonin and the chemotherapy drug cisplatin, may enhance anti-cancer effects against certain bone cancer cells while potentially allowing for lower cisplatin doses. The study, published in Naunyn-Schmiedeberg’s Archives of Pharmacology, was conducted by researchers from Yozgat Bozok University and Erciyes University. It focused on osteosarcoma and …
