2025’s Most Popular Cannabis Strains

Runtz.

Throughout 2025, consumer purchasing data, dispensary menus, and retail trends point to a mix of long-established favorites and newer genetics driving marijuana sales across legal U.S. markets.

While potency remains a factor, consistency, availability, and recognizable strain names continue to shape buying habits. The following list highlights the strains that most frequently appeared at the top of sales charts and menus over the past year.

Using data from state regulatory agencies, the research firm Headset, and the review site Leafly, here are 2025’s most popular cannabis strains.

Runtz

Runtz remained one of the most recognizable strain names in 2025. Its broad appeal comes from consistent effects and widespread availability, especially in states with mature recreational markets.

Wedding Cake

Wedding Cake continued to perform well in both flower and preroll sales. Its indica-leaning profile and higher THC levels make it a common choice for experienced consumers and those looking for relief from chronic pain, particularly in adult-use markets.

Blue Dream

A long-standing favorite that continued to rank near the top in 2025, Blue Dream is a sativa-leaning hybrid known for its balanced effects and approachable potency. It remains widely stocked across legal markets due to steady consumer demand and consistent cultivation results.

Gelato

Gelato maintained strong popularity in 2025, driven by its reliable potency and dense, resinous flower structure. Consumers frequently choose it for evening use, and it remains a staple among West Coast producers.

Sour Diesel

Sour Diesel sustained its relevance despite being an older cultivar. Many consumers still gravitate toward it for daytime use, and it remains a frequent top seller in East Coast dispensaries.

Gorilla Glue

Often labeled GG4, this strain continued to post strong sales in 2025. Its reputation for high potency and sticky flower keeps it popular among consumers looking for heavier effects.

OG Kush

OG Kush remained a foundational strain throughout 2025. While newer genetics enter the market each year, OG Kush continues to anchor many menus and is frequently used in breeding programs.

Ice Cream Cake

Ice Cream Cake saw steady demand in 2025, particularly in flower form. Its indica-dominant effects and dense buds have made it a reliable option for nighttime consumers.

Jack Herer

Despite being a mainstay for decades, Jack Herer maintained a consistent following in 2025, especially among medical marijuana patients. Its clearer, functional effects contribute to its long-term staying power.

Zkittlez

Zkittlez continued to rank highly across multiple states. It is commonly selected for its moderate potency and broad appeal rather than extreme THC levels.

White Widow

White Widow remained relevant in 2025 as a legacy strain that still performs well at retail. Its balanced effects and recognizable name keep it in rotation at many dispensaries.

Biscotti

Biscotti grew in popularity throughout 2025, particularly among consumers seeking indica-leaning hybrids. It is frequently sold in both premium flower and concentrate formats. Known for its sweet flavor and smell, Biscotti is expected to continue climbing up the charts in 2026.

Slurricane

Slurricane gained traction in 2025 as a heavier hybrid option. It has become more common in limited drops and small-batch cultivations, and is a sought-after strain by many cannabis consumers.

Permanent Marker

Permanent Marker continued to gain traction in 2025 as a widely stocked hybrid across several adult-use markets. Its consistent potency and expanding availability helped push it into regular rotation at dispensaries, particularly in flower and preroll categories.

Animal Mints

Animal Mints continued to see high demand, particularly in markets where higher-THC strains dominate sales. It is often selected for evening or late-night use.

MAC (Miracle Alien Cookies)

MAC remained a top-selling hybrid in 2025. Its distinct bud structure and balanced effects contribute to continued consumer interest.

Cherry Pie

Cherry Pie stayed popular due to its consistent effects and long presence in legal markets. It remains especially common in California and neighboring states.

Pineapple Express

Pineapple Express maintained solid sales in 2025, supported by strong name recognition and approachable effects that appeal to newer consumers.

Purple Punch

Purple Punch continued to perform well as an indica-dominant option. It remains popular in flower and infused preroll categories.

London Pound Cake

London Pound Cake grew its footprint in 2025, particularly in premium flower tiers. It is frequently associated with higher potency and dense buds.

Tahoe OG

Tahoe OG continued to post steady sales in 2025, driven largely by longtime fans of traditional OG Kush–derived strains. It is commonly carried as a core menu item, particularly in markets where classic West Coast genetics remain popular.

Super Lemon Haze

Super Lemon Haze maintained strong demand in 2025, especially among consumers looking for an uplifting daytime strain. It performed consistently across flower and vape products, with its citrus-forward profile helping it remain recognizable and easy to market.

Bruce Banner

Bruce Banner stayed relevant through 2025, largely due to its high THC levels and fast-acting hybrid effects. Retailers often position it toward more experienced consumers seeking stronger options without moving fully into heavy indica territory.

RS11

RS11 continued to gain ground in 2025 as distribution widened, becoming a regular offering in several competitive state markets. Its modern genetics and consistent quality helped it transition from limited drops to more reliable shelf presence.

Cookies and Cream

Cookies and Cream saw continued, dependable interest in 2025, supported by its approachable balance of effects and familiar dessert-leaning profile. It is frequently suggested to consumers looking for a middle-ground option that appeals across experience levels.