A new study published by the peer-reviewed journal Materials Today Bio found that a CBD-loaded drug delivery system showed radioprotective effects in mice exposed to gamma radiation.
The study examined a gamma-ray-responsive nanoplatform designed to release cannabidiol, or CBD, after radiation exposure. Researchers created polymer micelles known as mPEG-SeSe-St@CBD, which encapsulated CBD and were designed to remain stable until activated by gamma irradiation.
According to the study, the micelles had a particle size of about 155 nanometers, a negative surface charge and a stable spherical structure. In laboratory testing, the CBD-loaded micelles responded to low-dose gamma irradiation, rapidly breaking apart after exposure to 5 Gy of radiation and releasing more than 60% of their CBD within six hours.
Researchers said the delivery system was designed to reduce unnecessary drug exposure when radiation is not present, while allowing CBD to be released when radiation damage occurs.
In mouse experiments, the CBD-loaded micelles promoted body weight recovery after radiation exposure and improved cellular and tissue uptake. The treatment also reduced intracellular oxidative stress and provided protective effects across multiple organs.
Most notably, the study found that the system increased the 30-day survival rate of irradiated mice to over 50%.
The findings suggest that CBD-based nanomedicine could have potential as a radioprotective strategy for acute radiation injury, though the research remains preclinical. The study was conducted in laboratory and animal models, meaning further research would be needed to determine whether the approach is safe or effective in humans.
The researchers said the platform’s sensitivity to gamma radiation and its ability to remain intact without radiation exposure make it a promising candidate for future development.
