The marijuana compound cannabidiol (CBD) used without any other epilepsy medications appears to be safe and effective “for up to 12 months in clinical practice” when used by those with Lennox-Gastaut syndrome (LGS) or Dravet syndrome.
This retrospective chart review study evaluated plant-derived highly purified cannabidiol use without other medications as add-on therapy in patients aged ≥2 years with Lennox-Gastaut syndrome (LGS) and Dravet syndrome (DS) who were enrolled in a European Early Access Program.
Of 114 enrolled patients, data were available for 107 (92 LGS, 15 DS) who received CBD without clobazam (an epilepsy medication) for at least three months. The mean age was 14.5 for those with LGS and 10.5 for those with DS. Mean time-averaged CBD dose was 13.54 (LGS) and 11.56 (DS) mg/kg/day.
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