Study Finds Weak Correlation Between THC Blood Levels and Impairment

A new study published in Forensic Science International reveals that while alcohol and benzodiazepines have a clear and significant impact on driver impairment as their blood concentrations rise, the effects of THC are much less consistent and harder to predict, calling into question per se THC driving limits.

The research, which examined over 15,000 cases of impaired driving, highlights the complexity of assessing impairment from different substances, with alcohol and benzodiazepines showing a strong correlation between concentration and impairment, unlike THC and amphetamines.

The study aimed to determine how blood concentrations of ethanol, benzodiazepines, amphetamines, and tetrahydrocannabinol (THC) correlate with the severity of driver impairment, as measured by a Clinical Test of Impairment (CTI). Researchers utilized data from a national database, analyzing 15,514 individual mono-drug cases collected over nine years. The study population was predominantly male, with a median age of 34 years. In addition to these cases, 3,684 drug-free drivers with similar age and gender distribution were included as a reference group.

The results revealed a strong correlation between increased blood concentrations of ethanol and benzodiazepines and the severity of driver impairment. The percentage of drivers classified as impaired increased significantly with higher concentrations of these substances—from 60% to 97% for ethanol and from 38% to 76% for benzodiazepines.

Conversely, the correlation between blood concentrations and impairment was notably lower for amphetamines and THC. The study found that impairment increased only modestly with higher concentrations of these drugs, from 43% to 58% for amphetamines and from 41% to 55% for THC. The correlation between drug concentration and the degree of impairment was highest for ethanol (Spearman’s rho=0.548, p<0.001) and relatively high for benzodiazepines (Spearman’s rho=0.377, p<0.001), but low for amphetamines (Spearman’s rho=0.078, p<0.001) and THC (Spearman’s rho=0.100, p<0.001).

The percentage of impaired drivers increased with increasing blood drug concentration for all four drug classes, most pronounced for ethanol and benzodiazepines and much less for amphetamines and THC. The median blood drug concentration increased with increasing magnitude of impairment for ethanol and benzodiazepines, while this was much less pronounced for amphetamines and THC. The ranges of drug concentrations, however, were wide for all four drug classes in all impairment categories as assessed by individual clinical examination.

The results call into question the validity of per se THC driving limits, which find an individual guilty of a DUID if they have a specific amount of THC in their blood, regardless of actual impairment. Currently, there are at least six states with per se THC driving limits: Colorado, Montana, Nevada, Ohio, Illinois, and Washington.

Thank you for reading The Marijuana Herald! You can find more news stories by clicking here, and you can sign up for daily news updates by clicking here

 

More articles from The Marijuana Herald can be found below.

Public Marijuana Possession and Consumption Would be Downgraded to Civil Violation Under New Delaware Bill

Public Marijuana Possession and Consumption Would be Downgraded to Civil Violation Under New Delaware Bill

Washington, D.C. Medical Marijuana Sales Hit $100.9 Million in 2025 as Patient Count Grows to Nearly 100,000

Washington, D.C. Medical Marijuana Sales Hit $100.9 Million in 2025 as Patient Count Grows to Nearly 100,000

Connecticut Sets New Monthly Marijuana Sales Record in December as Prices Hit All-Time Low

Connecticut Sets New Monthly Marijuana Sales Record in December as Prices Hit All-Time Low

Study: CBD Shows Potent Antibacterial Activity Against Drug-Resistant Enterococcus Strains

Study: CBD Shows Potent Antibacterial Activity Against Drug-Resistant Enterococcus Strains

Study: Hemp Seed Extracts May Enhance Effectiveness of Antibiotics and Antifungal Medications

Study: Hemp Seed Extracts May Enhance Effectiveness of Antibiotics and Antifungal Medications

Study: CBD Gel Reduced Jaw Muscle Activity in Adults With Temporomandibular Disorders

Study: CBD Gel Reduced Jaw Muscle Activity in Adults With Temporomandibular Disorders

Indiana Senate Bill Would Legalize Recreational Marijuana, Including Licensed Sales

Indiana Senate Bill Would Legalize Recreational Marijuana, Including Licensed Sales

Low-Dose CBD Protected Developing Heart From Oxygen-Related Injury in Newborn Animal Study

Low-Dose CBD Protected Developing Heart From Oxygen-Related Injury in Newborn Animal Study

Randomized Controlled Trial Finds CBD May Reduce Anxiety and Perceived Effort in Runners

Randomized Controlled Trial Finds CBD May Reduce Anxiety and Perceived Effort in Runners

Study: Cannabis Extract Triggered Cell Death and Reduced Invasion in Human Breast Cancer Cells

Study: Cannabis Extract Triggered Cell Death and Reduced Invasion in Human Breast Cancer Cells

Vermont Bill Would Require Cities to Vote on Allowing Marijuana Stores During 2026 Election

Vermont Bill Would Require Cities to Vote on Allowing Marijuana Stores During 2026 Election

Tilray Brands Posts Record $217.5M Q2 Revenue

Tilray Brands Posts Record $217.5M Q2 Revenue

Study: CBD Reduced Bladder Pain and Inflammation in Animal Model of Interstitial Cystitis

Study: CBD Reduced Bladder Pain and Inflammation in Animal Model of Interstitial Cystitis

CBD Reduces Bacteria That Causes Gum Disease, Finds New Lab Study

CBD Reduces Bacteria That Causes Gum Disease, Finds New Lab Study

New York Bill Would Give Cannabis Distributors More Time to File Quarterly Tax Returns

New York Bill Would Give Cannabis Distributors More Time to File Quarterly Tax Returns

New Hampshire: Bipartisan Psilocybin Bills Scheduled for Public Hearing on January 14

New Hampshire: Bipartisan Psilocybin Bills Scheduled for Public Hearing on January 14

Maine Marijuana Sales Reach $246 Million in 2025, With 4.8 Million Transactions

Maine Marijuana Sales Reach $246 Million in 2025, With 4.8 Million Transactions

Study: Marijuana Appears in 37% of U.S. Hip-Hop Music Videos

Study: Marijuana Appears in 37% of U.S. Hip-Hop Music Videos