A new clinical trial from Johns Hopkins University School of Medicine finds that delta-8 THC (Δ8-THC), a growingly popular hemp-derived cannabinoid, produces psychoactive effects similar to those of delta-9 THC (Δ9-THC), but only when consumed in higher doses.
Delta-8 THC gummies.
The peer-reviewed study, published in the journal Drug and Alcohol Dependence, involved 19 healthy adult participants with no recent cannabinoid use. In a double-blind, crossover design, subjects were given brownies containing 10, 20, or 40 milligrams of Δ8-THC, 20 milligrams of Δ9-THC, or a placebo. Researchers then measured drug effects, blood cannabinoid levels, vital signs, and performance on cognitive and psychomotor tasks.
Results showed that Δ8-THC produced dose-dependent psychoactive effects that were qualitatively similar to those of Δ9-THC. However, the study found that 20 mg of Δ8-THC produced significantly weaker effects than an equivalent dose of Δ9-THC—including reduced intoxication, heart rate elevation, and cognitive impairment. At 40 mg, Δ8-THC’s effects were comparable to those of 20 mg of Δ9-THC.
The study also noted that the psychoactive 11-OH metabolite of Δ8-THC appeared in much lower concentrations compared to Δ9-THC, which may explain the lower potency. Still, participants reported similar levels of drug liking at the higher Δ8-THC dose.
Researchers conclude by stating:
Δ8-THC demonstrated dose-dependent psychoactive effects qualitatively similar to Δ9-THC but with reduced potency, possibly due to lower biotransformation to its 11-OH metabolite. Importantly, higher doses of Δ8-THC offset reduced potency, as 40 mg Δ8-THC and 20 mg Δ9-THC produced similar effects; this is noteworthy considering consumers generally perceive Δ8-THC as less harmful or intoxicating than Δ9-THC. These findings inform regulatory decisions and public education, though further research on emergent cannabinoids is needed.
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