A study published in the Dentistry journal reports that cannabidiol (CBD) may help combat bacteria and fungi linked to oral disease.
The review was conducted by researchers from the University of the Republic, the Federal University of Pelotas, the University of the Andes Mérida, and the Federal University of Jequitinhonha and Mucuri Valleys.
Researchers sifted through seven major scientific databases and screened 1,284 articles, ultimately selecting 10 studies published between 2019 and 2025 that directly tested CBD on oral microorganisms. Most of the studies evaluated CBD using minimum inhibitory concentration tests and colony-forming unit counts, with experiments involving either dilution or direct contact between CBD and bacterial or fungal cultures.
The review found that CBD demonstrated antimicrobial activity against several oral pathogens, including bacteria and fungi commonly linked to gum disease, tooth decay and oral infections. While the studies were largely preclinical—either in vitro or conducted in animal models—the results indicate CBD may have value as a future tool for managing oral health conditions.
The authors note that research in dentistry remains limited and that controlled clinical studies will be needed to determine whether CBD can be safely and effectively incorporated into oral health treatments. But based on the available evidence, the review suggests CBD holds meaningful potential as an antimicrobial agent in the dental field.
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