Nearly 400 businesses have signed up through the Drug Enforcement Administration’s new Medical Marijuana Dispensary Registration Portal, just days after the system opened to applicants.
The portal launched April 29 at 12 p.m. Eastern Time through the DEA’s Diversion Control Division, giving businesses a formal pathway to begin registering as medical marijuana dispensaries under the federal government’s new medical marijuana rescheduling framework.
As of the morning of May 2, the portal has at least 391 signups, marking a rapid early response from businesses looking to participate in the system. The surge comes as state-licensed medical marijuana businesses begin navigating the federal registration process following the Department of Justice’s April order rescheduling FDA-approved and state-sanctioned medical cannabis, while setting up an expedited process to reschedule all cannabis (with a hearing set for June 29).
The portal allows applicants to begin and submit an application to register as a medical marijuana dispensary. Businesses are required to pay a $794 annual application fee before submitting, with the fee listed as nonrefundable.
The online application includes seven sections: personal and business information, activity, state licenses, liability questions, compliance information, payment and submission. Applicants must provide business and contact details, ownership information, tax identification or Social Security information, state license information and details about whether the business has experience handling controlled substances.
The portal also asks whether the business is requesting to handle marijuana, marijuana extract or naturally derived delta-9-THC in either an FDA-approved product or marijuana subject to a state medical marijuana license. Applicants must also state whether they will handle or dispense medical marijuana, recreational marijuana or both.
The compliance section asks for supplier information, standard operating procedures and security measures, including whether the business location has a vault, safe, secure storage room, access controls, an alarm system or onsite security personnel.
Once submitted, applicants receive a confirmation notice and email.




