Wedding Cake.
Using data from cannabis research firm Headset, state-level sales data and the strain review site Leafly, the following list highlights 15 of the most popular marijuana strains in the U.S. as of September 2026.
Blue Dream
Blue Dream remains one of the most commercially resilient marijuana strains in the country. Generally described as a cross between Blueberry and Haze, it is a THC-dominant hybrid. Consumers frequently report cerebral stimulation accompanied by more moderate physical relaxation.
GG4
GG4, also known as Original Glue, remains among the most widely recognized strains in the U.S. A cross involving Chem’s Sister, Sour Dubb and Chocolate Diesel, GG4 typically has a THC-dominant cannabinoid profile, with reported effects tending toward pronounced physical relaxation.
Runtz
Runtz continues to maintain substantial national demand. The hybrid combines Zkittlez and Gelato genetics and typically contains relatively little CBD compared with THC. Consumer reports commonly describe a combination of euphoria, sociability and physical relaxation.
Wedding Cake
Wedding Cake remains a major seller across established recreational markets. This hybrid is generally described as a cross between Triangle Kush and Animal Mints. It is commonly high in THC, with consumer reports tending to emphasize relaxation, appetite stimulation and euphoria.
Animal Face
Animal Face has developed particularly strong demand in several East Coast markets. Bred from Face Off OG and Animal Mints, the hybrid is known for producing high concentrations of THC with comparatively little CBD. Users commonly report euphoria followed by substantial physical relaxation.
Permanent Marker
Permanent Marker has maintained significant national visibility in recent years. The modern hybrid combines Biscotti, Sherb and Jealousy-related genetics and is typically characterized by high THC concentrations and minimal CBD. Reported effects include euphoria, relaxation and altered sensory perception that can become pronounced at higher doses.
Gelato
Gelato remains one of the defining hybrids of the modern U.S. marijuana market and has also produced numerous commercially successful descendants. The strain combines Sunset Sherbet and Thin Mint GSC genetics and is generally THC-dominant. Users commonly report both mental stimulation and physical relaxation.
Sour Diesel
Sour Diesel has maintained national popularity for decades. Commonly associated with Chemdawg and Super Skunk genetics, it differs from many other strains on this list in that consumer reports more frequently describe stimulating and energizing effects.
Ice Cream Cake
Ice Cream Cake has become one of the more prominent descendants of the Gelato and Wedding Cake genetic families. The indica-leaning hybrid is generally described as a cross between Wedding Cake and Gelato #33 and typically produces THC-dominant flower. Consumer reports strongly favor relaxing and sedating effects.
GSC
GSC, also known as Girl Scout Cookies or simply Cookies, remains one of the most influential strains in the legal marijuana market, both through direct sales and the large number of subsequent strains incorporating its genetics. The hybrid is generally linked to OG Kush and Durban genetics, with reported effects including euphoria followed by physical relaxation and increased appetite.
Purple Punch
Purple Punch remains widely available nationally. Created from Larry OG and Granddaddy Purple, it is a THC-dominant hybrid generally associated with a more calming consumer-reported profile. Relaxation, sleepiness and increased appetite are among its most frequently reported effects.
OG Kush
OG Kush remains one of the most recognizable marijuana strains in the U.S. and an important genetic foundation for numerous modern hybrids. Its precise ancestry remains debated, although it is closely associated with Chemdawg and Kush genetics. Typical samples are THC-dominant, with consumer reports generally describing combined cerebral and physical effects that become increasingly relaxing at higher doses.
Granddaddy Purple
Granddaddy Purple remains a major legacy strain more than two decades after its introduction. Commonly associated with Purple Urkle and Big Bud genetics, although competing lineage accounts exist, the strain is generally THC-dominant. Consumers most frequently report pronounced relaxation, sleepiness and appetite stimulation.
Hash Burger
Hash Burger has rapidly developed into a significant commercial strain. A cross between Han Solo Hash Plant and Double Burger, Hash Burger commonly produces high-THC flower, with consumer reports generally characterizing its effects as strongly relaxing and potentially sedating.
Gary Payton
Gary Payton has continued to expand nationally in 2026. A cross between Snowman and The Y, Gary Payton is a THC-dominant hybrid. Consumer reports generally describe a comparatively balanced combination of euphoria, mental activity and physical relaxation.
