Topical Cannabis Balms With THC and CBD Can Ease Joint Pain From Breast Cancer Treatment
A clinical study found that topical balms containing THC and CBD reduced joint pain and stiffness in patients undergoing breast cancer therapy compared with controls, improving comfort with minimal systemic effects.
Cannabinoids Show Selective Antibacterial Effects Against Common Dental Pathogens
A lab study found several cannabinoids exhibited targeted antibacterial activity against bacteria linked to dental decay and gum disease, with minimal effects on beneficial oral microbes. Findings suggest potential for cannabinoid-based oral care agents pending further research.
CBD Selectively Kills Cancer Cells While Sparing Healthy Cells
Researchers reported that CBD reduced viability in multiple cancer cell lines but had limited impact on non-cancerous cells in vitro. The selective effect highlights CBD’s potential as a targeted anticancer agent, although clinical trials are still needed.
Marijuana Use Linked to Lower Mortality and Fewer Liver Complications in Patients With Fatty Liver Disease But Higher Heart Risks
An observational study found that people with fatty liver disease who use cannabis had lower adjusted mortality and fewer liver-related complications over time but were more likely to have cardiovascular events. Researchers emphasize balancing potential benefits with heart risk monitoring.
CBD Shows Broad Anti-Tumor Effects But Human Trials Still Needed
Preclinical research across multiple tumor models found CBD inhibited cancer cell growth and spread in vitro and in animals. While results are promising, authors note the need for rigorous human clinical trials to confirm therapeutic relevance.
Clinical Trial: CBD With Terpenes May Reduce Anxiety and Parental Stress in Autistic Children
A small clinical trial found that a CBD-plus-terpene formulation reduced anxiety symptoms in autistic children and eased parental stress compared with placebo. Treatment was well tolerated, though larger studies are required to validate findings.
CBD-Loaded Biohybrid Micelles Show Enhanced Anti-Cancer Effects in Colon Cancer Cells
Researchers engineered CBD-loaded biohybrid micelles that improved delivery into colon cancer cells and significantly increased anticancer activity compared with CBD alone. The formulation enhanced cellular uptake and tumor-killing effects in lab tests.
Cannabidiol Shows Protective Effects Against Acute Liver Injury by Preserving Mitochondrial Function
A preclinical study found CBD helped protect against acute liver injury by stabilizing mitochondrial function and reducing oxidative stress and inflammation. Results point to CBD’s potential role in limiting liver cell damage.
Medical Marijuana Linked to Sustained Improvements in Sleep Quality Over One Year
A year-long observational study found medical marijuana use was associated with lasting improvements in sleep quality scores, with many participants reporting better sleep consistency and duration over time.
CBD May Protect the Brain From Damage Caused by Common Food and Environmental Pollutant
Researchers reported that CBD reduced oxidative stress and cellular damage in brain tissue exposed to a widely encountered food and environmental contaminant, suggesting neuroprotective potential against toxin-related injury.
Yale Study: CBD May Alter Pain Sensitivity and Opioid Craving in Patients on Methadone or Buprenorphine
A Yale study found CBD influenced pain sensitivity and reduced opioid craving in individuals receiving methadone or buprenorphine treatment, indicating possible supportive benefits during opioid use disorder therapy.
CBD Reduces Stress-Related Behaviors in Ornamental Fish During Transport
A study found that adding CBD to water during transport reduced stress behaviors in ornamental fish, suggesting a potential method for improving animal welfare during shipping.
Inhaled CBD Reverses Seizure Risk and Brain Inflammation Linked to Chronic Nicotine Pouch Use
Researchers found inhaled CBD reversed seizure susceptibility and reduced brain inflammation in an animal model exposed to chronic nicotine pouch use, indicating possible protective neurological effects.
Melatonin and Zinc Oxide Nanoparticles Boost Growth, Stress Tolerance, and Cannabinoid Production in Cannabis Sativa
A plant study showed that treating cannabis with melatonin and zinc oxide nanoparticles improved growth rates, stress resilience, and cannabinoid output, pointing to new cultivation optimization methods.
New Study Unveils High-Precision Technique for Testing Cannabinoids in Oils and Flower
Researchers developed a highly accurate testing method for measuring cannabinoids in both oils and plant material, improving consistency and reliability in laboratory cannabinoid analysis.
Cannabis-Based Medicines Linked to Long-Term Quality-of-Life Improvements in Multiple Sclerosis Patients
A real-world study of 203 people with multiple sclerosis found sustained improvements in energy, physical function, pain, sleep, and overall health for up to two years after starting cannabis-based medicinal products. Benefits remained statistically significant over time, and most adverse effects were mild.
Rare Varin Cannabinoids Show Potent Anticancer Activity in Lab Tests
Lab research found that rare varin cannabinoids significantly reduced the viability and growth of several human tumor cell lines in vitro. The findings suggest these lesser-known cannabinoids may warrant further investigation as potential antitumor agents.
THC Alzheimer’s Clinical Trial Shows Cognitive Gains
A phase 2 clinical trial found that a low-dose THC-CBD extract improved cognitive test scores in people with Alzheimer’s-related dementia over 26 weeks compared with placebo. The treatment was well tolerated, indicating possible therapeutic value for cognitive symptoms.
CBD Reduces Placental Inflammation in Preclinical Study
Preclinical research showed that CBD reduced inflammatory markers in placental tissue exposed to inflammatory stimuli. Results indicate CBD may influence immune responses at the maternal–fetal interface, though further research is needed.
Long-Acting Injectable CBD Shows Weeks-Long Presence in Calves, Suggesting Possible Use for Painful Farm Procedures
Researchers found that a long-acting injectable CBD formulation maintained detectable blood levels for several weeks in calves after a single dose and was linked to prolonged signs of pain relief, pointing to potential use in livestock pain management.
CBD May Help Stabilize Brain Chemistry in People at High Risk for Psychosis
A study from King’s College London found that a single 600 mg dose of CBD altered glutamate signaling patterns in people at high risk for psychosis, shifting abnormal correlations seen with placebo toward more normalized patterns during a memory task. Researchers say this modulation may help regulate pathways tied to early psychosis symptoms.
Betel Leaf and CBD Formulations Show Antibacterial Activity Against Drug-Resistant Canine Skin Infections
In vitro research found that both betel leaf extract and certain CBD formulations had strong antibacterial effects against methicillin-resistant canine Staphylococcus isolates. Authors say further in vivo research is needed to confirm potential clinical use for resistant skin infections.
Soil Conditions Can Dramatically Reshape Hemp’s Cannabinoid Profile
Hemp grown in different soil preparations showed notable shifts in CBD, CBDA, CBG, and THC levels, even when using the same cultivars. The findings highlight how soil management can significantly influence cannabinoid consistency for growers.
Medical Marijuana Use Linked to Reduced Pain and Lower Reliance on Prescription Painkillers
A survey of more than 2,000 medical marijuana patients found average pain reductions and patterns indicating many reduced or stopped prescription pain medications after beginning cannabis use for chronic pain.
CBD May Counteract Methamphetamine-Related Neurotoxicity by Targeting S1R
Cell and mouse research found that CBD reduced methamphetamine-induced sigma-1 receptor activity, lowering oxidative stress and cellular damage linked to neurotoxicity. Findings suggest CBD’s action on S1R pathways may help limit neurological harm.
Cannabis Substitution in Managed Alcohol Programs Reduces Daily Drinking, Study Finds
A new analysis found that offering cannabis alongside controlled alcohol dosing in a Managed Alcohol Program was linked to lower daily alcohol consumption. In a pilot with 35 participants, more cannabis use corresponded with fewer standard drinks per day, suggesting substitution could help reduce alcohol-related harms.
Cannabis Use Linked to Lower Rates of Chronic Rhinosinusitis and Fewer Sinus Surgeries in New Study
Researchers analyzing health records of more than 73,000 matched adults found that people who use cannabis had lower adjusted risks of developing chronic rhinosinusitis and were less likely to undergo sinus surgery over one to five years compared with non-users. The results point to a potential protective association.
3D-Printed CBD Hydrogels Show Strong Potential for Oral Drug Delivery
Researchers developed 3D-printed hydrogels loaded with CBD designed for controlled release in the oral cavity. The materials maintained structural stability and showed properties suitable for sustained cannabinoid delivery, offering a promising platform for localized therapeutic use.
CBD Shows Antimicrobial Potential Against Oral Pathogens, Study Finds
A review of preclinical research found that cannabidiol (CBD) demonstrated antimicrobial activity against several bacteria and fungi linked to oral disease. While mainly in vitro or animal studies, findings suggest CBD could be a future tool for managing oral health, though clinical research is still needed.
CBD Found to Reduce Emotional, Molecular, and Alcohol-Seeking Effects of Prenatal Alcohol Exposure
A mouse study found that cannabidiol (CBD) improved emotional behavior, normalized several brain biomarkers, and reduced alcohol-seeking behavior caused by prenatal alcohol exposure. Effects varied by sex, with females showing a stronger reduction in alcohol-seeking behaviors. Results suggest CBD could help address long-term emotional and molecular changes from fetal alcohol spectrum disorder.
Clinical Trial: CBD Shown to Reduce Behavioral Symptoms in Older Adults With Vascular Dementia
In a small clinical trial, daily CBD (300 mg) over four weeks eased behavioral and psychological symptoms in older adults with vascular dementia compared with placebo. Cognitive and functional abilities remained stable, and side effects were mild. Researchers say larger, longer studies are needed.
CBD and CBG Resolve Trigeminal Neuralgia and Postherpetic Neuropathy
A case report described dramatic pain relief in a patient with trigeminal neuralgia and postherpetic neuropathy after high-dose CBD paired with CBG. Within two weeks, the patient’s pain fully resolved, enabling reduced use of other therapies. Findings point to cannabinoid combinations as potential options for severe neuropathic pain.
CBD Boosts the Effectiveness of Phenobarbital in a Newborn Seizure Model
In an animal model of neonatal seizures, combining CBD with low-dose phenobarbital significantly improved seizure control compared with either treatment alone. CBD enhanced phenobarbital’s effectiveness, suggesting potential as an adjunct therapy in hard-to-treat neonatal seizures.
Liposomal CBD Injections Show Weeks-Long Pain Relief and Steady CBD Levels in Goats
Researchers tested slow-release liposomal CBD injections in goats with chronic pain and found sustained blood levels of CBD and consistent pain relief over several weeks with no adverse effects. The approach may inform long-acting CBD formulations for prolonged pain management.
Clinical Trial Finds THC Significantly Reduces Alcohol Consumption in Heavy Drinkers
In a randomized trial of heavy drinkers, administration of THC led to a marked reduction in alcohol intake and craving compared with placebo, suggesting THC might serve as a potential harm-reduction tool for alcohol use disorder.
Study: Cannabis Use Linked to Lower Rates of Chronic Rhinosinusitis and Fewer Sinus Surgeries in New Study
A large retrospective analysis found that regular cannabis users had significantly reduced incidence of chronic rhinosinusitis and required fewer sinus surgeries compared with non-users, hinting at a potential protective or anti-inflammatory effect of cannabis on sinonasal health.
Study: CBD Shows Antispasmodic and Antidiarrheal Benefits in New Gastrointestinal Study
Researchers reported that CBD reduced intestinal spasms and normalized bowel motility in preclinical models, also decreasing frequency and severity of diarrhea — pointing toward therapeutic promise for conditions like IBS or other GI disorders.
Study: CBD-Rich Marijuana Eases Anxiety and Repetitive Behaviors in Autistic Children, Finds Study
In an observational cohort of autistic children, use of CBD-dominant cannabis was associated with reductions in anxiety, irritability, and repetitive behaviors, along with improvements in social responsiveness; parents reported these changes within weeks of use.
Study Finds CBD Shields Primary Neurons From Rotenone-Induced Toxicity Through TRPV1 Pathways
In neuronal cell cultures exposed to rotenone (a Parkinson’s-linked neurotoxin), CBD treatment preserved neuron viability by activating TRPV1 receptor pathways, reducing oxidative stress and limiting mitochondrial dysfunction — indicating neuroprotective potential against environmental toxins.
Clinical Trial: CBD Shown to Reduce Behavioral Symptoms in Older Adults With Vascular Dementia
In a randomized clinical trial, older adults with vascular dementia receiving CBD experienced reductions in agitation, anxiety, and aggression, along with modest improvements in mood and caregiver-reported quality of life—suggesting CBD may help manage neuropsychiatric symptoms in dementia.
Study: CBD Found to Reduce Emotional, Molecular and Alcohol-Seeking Effects of Prenatal Alcohol Exposure
In animal models exposed prenatally to alcohol, CBD treatment later in life reduced anxiety-like behaviors, normalized stress-related brain molecular markers, and lowered propensity for alcohol seeking—pointing to therapeutic potential in mitigating developmental alcohol exposure effects.
Study: CBD Shown to Prevent Key Scarring Processes on the Eye’s Surface, Study Finds
Laboratory research demonstrated that topical CBD application suppressed fibroblast activation and collagen deposition on ocular surface tissues—processes linked to scarring and impaired vision—suggesting a possible role for CBD in preventing postoperative or injury-induced eye fibrosis.
