Research into cannabigerol (CBG), a non-intoxicating cannabinoid found in marijuana, has continued to expand in 2026, with studies examining its potential effects on cancer, chronic pain, neurological disorders, inflammation, cardiovascular health, metabolism and more.
Through October 15, The Marijuana Herald has covered at least 30 studies and research reports involving CBG in 2026, including research on isolated CBG, cannabinoid combinations and CBG-rich extracts. The collection includes human studies, animal experiments, laboratory research and a scientific review.
Below is a summary of each, with titles linking to our full coverage.
Study Finds CBD and CBG Protect Brain Cells From Toxic Damage, Identifies Key Receptor Behind Effects
Research published in ChemMedChem found that CBD and CBG protected cultured rat brain cells from injury caused by rotenone, a substance that disrupts mitochondrial function. Blocking the sigma-1 receptor eliminated the protective effects, identifying a mechanism that may help explain how the cannabinoids protect neurons in this laboratory model.
CBG Improved Grip Strength and Muscle Performance in Mice With Steroid-Induced Muscle Atrophy
CBG improved physical performance in mice with steroid-induced muscle wasting. When combined with resistance training, it increased ladder-climbing power output by as much as 87% compared with exercise alone. Researchers also reported an approximately 10% increase in peak grip strength, despite relatively modest changes in muscle fiber size.
Study: CBG Reduced Blood Pressure by 18% in Hypertensive Rats, Inhibited Blood Clot Formation in Human Blood Samples
A study in Molecules found that intravenous CBG temporarily reduced systolic blood pressure by 18% in hypertensive rats at the highest tested dose. Separate experiments using human blood samples found reduced platelet activation, aggregation and clot formation. The research did not establish lasting blood pressure benefits or effectiveness in patients.
Study: CBG and Terpenes Suppress Reflux-Related DNA Damage and Mutagenicity in Human Esophageal Cells
CBG combined with selected terpenes reduced DNA damage and oxidative stress caused by components of gastric reflux in cultured human esophageal cells. Combinations involving phytol and beta-caryophyllene showed particularly notable effects, including reduced genomic instability and damage associated with bile-acid exposure.
Placebo-Controlled Human Study Finds CBG Improves EEG Measures of Mood and Mental Clarity
A randomized, double-blind crossover study involving 18 adults found that a 25-milligram CBG tablet produced changes in EEG-derived measures associated with mood, sadness and confusion. Participants’ self-reported mood scores did not significantly differ from placebo, meaning the findings reflected the brain-signal analysis rather than reported improvements in how participants felt.
Study: CBG Enhances Adenosine Signaling at Human Receptor, Increasing Apparent Potency 138-Fold
Laboratory research published in Pharmacological Research found that CBG increased adenosine’s apparent potency at the human A3 receptor by approximately 138-fold. The receptor participates in inflammation and immune regulation. The result describes a change in a cellular assay, rather than a corresponding increase in medical benefit.
Study Finds CBD and CBG Disrupt Cavity-Causing Dental Biofilms, Including Established Biofilms
CBD and CBG inhibited the formation of mixed bacterial-fungal biofilms associated with tooth decay and disrupted established biofilms in laboratory testing. The study examined communities containing Streptococcus mutans and Candida albicans, providing a basis for further research into cannabinoid formulations for oral health.
Study Finds Cannabinoid Tablet Associated With 32% Reduction in Same-Day Pain and Improved Mood
An observational study of 427 adults found that a tablet containing CBDA, CBG and CBC was associated with a 32% reduction in same-day pain scores. Participants also reported improvements in mood and daily functioning. The company-associated study lacked a placebo group and had not been published in a peer-reviewed journal.
Study Finds CBD and CBG Extracts Show Strong Antioxidant and Antimicrobial Activity, CBG More Stable in Topical Formulation
Researchers found antioxidant and antimicrobial activity in both CBD-rich and CBG-rich extracts. CBG also retained substantially more of its original concentration in a topical emulsion during six months of accelerated stability testing: CBG content declined approximately 16%, compared with a roughly 65% decline in CBD.
CBD and CBG Combined With Sodium Pentaborate Show Anti-Cancer Effects in Human Colorectal Cancer Cells, Study Finds
CBD and CBG, each combined separately with sodium pentaborate, reduced proliferation and increased programmed cell death in human colorectal cancer cells. Some combinations produced synergistic effects, but results depended on the dose and cell line. Researchers also identified changes in genes involved in cellular stress and iron metabolism.
CBD and CBG Use After Chemotherapy Linked to Significantly Lower Neuropathy Risk, Study Finds
An analysis of electronic health records found that documented CBD or CBG exposure after neurotoxic chemotherapy was associated with an approximately 84% lower adjusted hazard of a subsequent neuropathy-related diagnosis. Exposure before chemotherapy was not associated with a significant reduction. The observational findings do not establish causation or isolate CBG’s effects.
Phytocannabinoids May Support Bone Health and Fracture Healing, Finds New Review
This scientific review examined evidence involving cannabinoids and bone health, including preclinical findings that CBG improved bone volume, mineral density and strength while reducing fracture pain. It also discussed CBG’s cartilage-protective effects in an osteoarthritis model. The article summarizes existing research rather than reporting a new CBG experiment.
Study: CBG Shows Antipsychotic-Like Effects in Model of Schizophrenia
Researchers from the University of São Paulo tested CBG in 224 male mice using drug-induced models of schizophrenia-related behavioral changes. CBG reduced hyperactivity and improved measures involving sensory processing, social interaction and recognition memory, supporting further investigation of its potential psychiatric applications.
Study: CBG and Full-Spectrum Cannabis Extract Reduce Inflammatory Pain in Animal Models
CBG and a predominantly CBD full-spectrum extract reduced pain-related behaviors in animal experiments. CBG reduced those behaviors by 87.1% during an early phase of acute testing. With repeated treatment in a persistent-pain model, CBG restored mechanical pain sensitivity to baseline levels beginning on day 15.
Study Finds CBG Prevented Long-Term Memory Deficits in Schizophrenia Model
Repeated CBG administration prevented long-term recognition-memory deficits in rats given MK-801, a drug used to model aspects of schizophrenia-related cognitive impairment. Researchers identified changes in TrkB receptor gene expression that may help explain the protective effect, although CBG did not restore reduced levels of the signaling protein BDNF.
Study Finds CBN and CBG With Melatonin Enhance Chemotherapy Against Glioblastoma Cells
CBN and CBG, each paired with melatonin, reduced the viability of human glioblastoma cells and enhanced the effects of temozolomide chemotherapy. Researchers tested three genetically distinct cancer cell lines and observed effects involving DNA damage and mitochondrial disruption. All experiments were conducted in cell cultures.
Study: Cannabis Extracts Show Antiviral Activity and Alter Immune Responses in Cells
A CBG-dominant extract was among several cannabis formulations that reduced bovine alphaherpesvirus 1 levels in infected cells. The CBG-rich extract also increased certain inflammatory signals in bovine immune cells, illustrating how cannabinoid composition can produce different immune responses. The study did not test treatment in humans.
Study Finds CBD, CBG and CBN Suppress Bile Duct Cancer Cells and Trigger Cell Death
CBD, CBG and CBN reduced viability and proliferation in two human bile duct cancer cell lines. The cannabinoids also disrupted mitochondrial function and triggered programmed cell death. Researchers found reduced levels of Ki67, a marker of cancer-cell proliferation, alongside changes in proteins involved in cancer-related signaling.
Study Finds CBG Improves Kidney Lipid Metabolism Following a High-Fat, High-Sugar Diet
CBG reduced the accumulation of stored fat in the kidneys of rats fed a high-fat, high-sugar diet. Treatment also altered proteins involved in fat metabolism, shifting the balance toward fatty acid breakdown and away from fat production. The findings suggest a possible role in limiting early metabolic kidney damage.
Oral CBG Safe and Well-Tolerated at Doses Up to 200 Milligrams in Human Study
A laboratory study involving 12 healthy adults tested single oral CBG doses ranging from 25 to 200 milligrams. No drug-related adverse events were reported, and researchers found no strong or consistent effects on cognition or physiological responses. The study addressed short-term tolerability rather than the safety of prolonged use.
Cannabis Compounds CBD and CBG May Help Protect Skin Cells From UVA-Related Damage, Study Finds
Research published in Antioxidants found that CBD, CBG and their combination countered several effects of UVA exposure in normal pigment-producing skin cells and melanoma cells. Treatments reduced markers of oxidative damage and inflammatory signaling while improving aspects of cellular antioxidant defenses.
Cannabinoids CBG and CBC Induce Cell Death in Lung Cancer Cells, Researchers Find
A study published in Antioxidants found that CBG and CBC induced cell death and apoptosis in two lung cancer cell lines. The laboratory findings support additional investigation of the cannabinoids as potential components of combination cancer treatments, without establishing effectiveness against lung cancer in patients.
Study: Cannabinoid Capsules Linked to Pain Relief in Fibromyalgia and Arthritis Patients
A 12-week study compared three cannabinoid formulations in adults with fibromyalgia, rheumatoid arthritis or osteoarthritis. One contained THCA, CBDA, CBG and CBC. Participants reported improvements across multiple symptom measures, and those using the CBG-containing formulation reported reduced neuropathic pain intensity. The study did not isolate CBG’s individual contribution.
Study: Minor Cannabinoids Show Distinct Effects on Pain-Sensing Neurons
Experiments using cultured mouse neurons found that CBD, CBG, CBN and CBC differed in their effects on cells involved in pain detection. CBG and CBD activated a broader range of neuron sizes, while the compounds displayed different dose-response patterns. The findings help characterize cannabinoid activity rather than demonstrate clinical pain relief.
Cannabinoid-Silver Combination Shows Potent Activity Against Drug-Resistant Bacteria, Study Finds
Combining silver with CBC and CBG produced strong antibacterial effects against MRSA, E. coli and Pseudomonas aeruginosa in laboratory testing. The combination reduced the silver concentration needed to inhibit bacteria by as much as 64-fold and also reduced bacterial biofilms.
Study: Cannabigerol Shows Antidepressant and Cognitive Benefits in New Study
CBG produced antidepressant-like effects in healthy mice and improved cognitive performance in mice exposed to chronic stress. The cognitive improvements were associated with increased dendritic spine density in the hippocampus, suggesting changes in the connections between nerve cells may contribute to its effects.
CBG Found to Trigger Multiple Cancer Cell Death Pathways in Pancreatic Tumor Cells
Research published in Free Radical Biology and Medicine found that CBG slowed pancreatic cancer-cell proliferation and triggered programmed cell death. Researchers identified cell-cycle arrest and changes involving apoptosis, ferroptosis and cellular stress pathways, offering possible mechanisms for further investigation in pancreatic cancer research.
Study: CBG-Dominant Cannabis Extract Reduces Fat Cell Formation and Boosts Fat Burning
A CBG-dominant cannabis extract reduced fat-cell development and increased markers associated with fat breakdown and energy expenditure in a laboratory model. Published in the International Journal of Molecular Sciences, the research examined cultured cells and did not establish weight-loss effects in people.
Study: Combining CBD and CBG Cuts Effective CBD Seizure Dose in Half in Standard Epilepsy Model
In a mouse seizure model, combining equal amounts of CBD and CBG reduced the CBD dose required to protect half the animals from 133 to 60 milligrams per kilogram. Researchers characterized the interaction as likely additive and found that the combination improved the overall balance between effective and toxic doses.
Study: Lesser-Known Marijuana Compounds Like CBDV and CBG Can Reduce Inflammation, Especially When Combined
Researchers tested 10 nonintoxicating cannabinoids in a human immune-cell model and found varying anti-inflammatory effects. Combining cannabinoids with other plant fractions strengthened some responses, with mixtures containing CBG or CBN among the most potent. The findings highlight the importance of examining cannabinoids alongside other cannabis components.
