CBD May Reduce Intestinal and Liver Damage in Acute Mesenteric Ischemia
CBD reduced intestinal tissue damage, improved intestinal function and helped protect the liver in a rat model of acute mesenteric ischemia. The treatment also reduced markers of oxidative stress, inflammation and cell death in both intestinal and liver tissue.
THC-CBD Cannabis Extract Suppresses Estrogen Receptor-Positive Breast Cancer Tumors
A whole-cannabis extract containing THC and CBD significantly reduced the growth of estrogen receptor-positive human breast cancer tumors implanted in mice. Tumor volume declined by as much as 75.9% in the highest-dose group, while tissue analysis showed reduced cancer-cell proliferation, although researchers cautioned that the findings remain preclinical.
THC Edibles Associated With Lower Pain Levels in People With Chronic Lower Back Pain
A study involving 243 adults with chronic lower back pain found that pain levels were significantly lower on days participants consumed THC-dominant edibles or products containing both THC and CBD. CBD-dominant products were not associated with a comparable reduction, while higher THC doses were linked to lower pain the following day.
Review Highlights Potential Anti-Inflammatory, Antioxidant and Pain-Relieving Properties of Cannabis Roots
A comprehensive review found that cannabis roots contain compounds with potential anti-inflammatory, antioxidant, antimicrobial and pain-relieving properties. Laboratory and animal studies found that root extracts could reduce inflammatory markers, inhibit certain bacteria and fungi and decrease pain-related behaviors, although the roots remain considerably less studied than other parts of the plant.
Study Validates Rapid Method for Measuring THC, CBD and Other Cannabinoids Without Physical Reference Standards
Researchers validated a rapid nuclear magnetic resonance method capable of simultaneously measuring THCA, CBDA, delta-9 THC, CBD and CBN without requiring physical cannabinoid reference standards. The method demonstrated strong precision and accuracy and could simplify cannabinoid testing while avoiding some limitations associated with traditional chromatographic techniques.
Researchers Identify Key Genetic Regions Controlling Cannabinoid and Terpene Diversity in Marijuana
Researchers identified a relatively small number of genetic regions that appear to control much of the variation in major cannabinoids and monoterpenes produced by marijuana plants. The findings could eventually help breeders more precisely develop varieties with targeted THC, CBD and terpene profiles.
Greek Doctors Support Medical Marijuana but Report Major Knowledge Gaps
A survey of 183 Greek oncologists, anesthesiologists and neurologists found broad support for medical marijuana but substantial gaps in physicians’ knowledge and familiarity with its use. Just 12.7% to 35% of doctors, depending on specialty, said they were familiar with medical marijuana, while knowledge scores concerning potential contraindications averaged about 15.5 to 20.2 out of 100.
CBD Reduced Inflammation and Fat Buildup in Human Immune Cells Exposed to Saturated Fat
CBD reduced inflammatory signaling and fat accumulation in human macrophage-like cells exposed to excess saturated fat. At higher concentrations, CBD reduced several inflammatory markers by roughly 45% to 85% and nearly prevented the intracellular triglyceride buildup caused by saturated-fat exposure.
CBD Reduced Seizure Severity and Memory Problems in an Animal Model of Epilepsy
CBD reduced seizure severity and improved recognition memory and synaptic function in rats with epilepsy-like symptoms. Researchers found that the HCN1 ion channel appears to contribute to CBD’s anticonvulsant and neuroprotective effects, although CBD also appeared to work through additional mechanisms.
Recreational Marijuana Legalization Increased Agricultural Employment by About 9%
States that launched recreational marijuana sales experienced an approximately 9% increase in agricultural employment, according to an analysis of employment and wage data from 45 states between 1990 and 2024. Researchers found no statistically significant effect on agricultural wages, overall employment or wages across the broader economy, with the employment gains varying considerably by legalization cohort.
Marijuana Use Linked to Improved Quality of Life and Symptom Relief Among Patients With Inflammatory Bowel Disease
A survey of 108 marijuana consumers with Crohn’s disease or ulcerative colitis found that 87.6% said marijuana improved their quality of life, with many also reporting relief from nausea, joint pain and insomnia. About 59% said marijuana reduced their use of opioid or narcotic painkillers, although the findings were based on self-reported experiences rather than objective measures of disease activity.
CBD, CBG and CBN Suppress Bile Duct Cancer Cells and Trigger Cell Death
CBD, CBG and CBN reduced the viability and proliferation of human bile duct cancer cells while triggering apoptosis, or programmed cell death, in laboratory testing. The cannabinoids also disrupted mitochondrial function and reduced a key marker of cancer cell proliferation, although the study did not evaluate the treatments in animals or people.
CBD and Anti-Inflammatory Drug Combination Shows Potential Against Aggressive Brain Tumors
A liposomal formulation combining CBD with the anti-inflammatory drug celecoxib altered inflammatory and oxidative-stress signaling in high-grade glioma cells and showed a trend toward slowing tumor progression in mice. Researchers said the results are preliminary but suggest the combination and its lipid-based delivery system warrant further study.
CBD Nanoparticles Improve Memory and Reduce Alzheimer’s-Related Brain Damage
CBD delivered through human serum albumin nanoparticles improved memory and reduced Alzheimer’s-related brain damage in cell and mouse models. Compared with free CBD, the nanoparticle formulation more effectively limited amyloid-beta aggregation and oxidative stress, while treated mice showed better cognitive performance, lower brain amyloid levels and reduced inflammatory markers.
Blocking Growth Hormone Pathway Makes Cannabis Plants Shorter While Increasing Cannabinoid Concentrations
Suppressing the gibberellin growth-hormone pathway made cannabis plants 66.8% shorter while increasing total cannabinoid concentrations by 78.6% and directing a larger share of plant biomass toward flowers. Researchers identified the pathway as a potential breeding target for developing compact cannabis plants with increased cannabinoid production, although the chemical inhibitor used in the study left problematic residues.
THC-CBD Medicine May Improve Multiple Sclerosis Symptoms Beyond Spasticity
A review and meta-analysis found that nabiximols, a marijuana-derived medicine containing THC and CBD, may improve sleep, bladder function, walking ability and muscle-spasm severity among people with multiple sclerosis. The analysis included 25 studies involving 2,949 patients and found that those treated for more than a month were 69% more likely than controls to report overall improvement.
Researchers Call for State-Led Medical Marijuana Research Centers Following Federal Rescheduling
Researchers argue that states with established medical marijuana programs should create independent research centers to standardize patient and product data, track outcomes and adverse events, and generate stronger real-world evidence on marijuana’s safety and therapeutic effects. They contend that federal rescheduling could reduce research barriers while giving states an opportunity to build a more coordinated scientific framework for medical marijuana.
CBD May Improve Cognition, Behavior and Sleep in People With Treatment-Resistant Epilepsy, Review Finds
A systematic review of 32 studies involving 1,343 patients with severe treatment-resistant epilepsy found that CBD was associated with improvements in cognition, behavior, communication, sleep and other outcomes beyond seizure control. Thirty-one of the studies reported improvement in at least one nonseizure outcome, although researchers cautioned that most were observational and carried a moderate to high risk of bias.
CBD Protects Brain Cells From Methamphetamine-Induced Damage, Study Finds
CBD protected hippocampal neurons from methamphetamine-induced damage in a laboratory study, improving cell viability and restoring more normal autophagy activity. Researchers found that the effects involved the serotonin 5-HT1A receptor and related cellular signaling, although the study was conducted using isolated brain cells rather than animals or humans.
Oral CBG Safe and Well-Tolerated at Doses Up to 200 Milligrams in Human Study
A human study involving 12 healthy adults found that oral CBG was well-tolerated at single doses ranging from 25 to 200 milligrams, with no drug-related adverse events reported. Researchers also found no strong or consistent effects on cognition, physiological measures or participants’ subjective experiences.
95% of Healthcare Professionals Surveyed Support Legal Medical Marijuana
A survey of 879 U.S. healthcare professionals found that 95% supported legal medical marijuana, 87% believed cannabis has therapeutic promise and 74% were open to recommending it to patients. Researchers also identified substantial gaps in objective cannabis knowledge despite participants reporting relatively high confidence in their understanding of its risks and therapeutic applications.
CBDA-Rich Cannabis Extract More Strongly Inhibits Epilepsy-Linked Sodium Channels Than Purified CBDA
A laboratory study found that a CBDA-rich cannabis extract inhibited epilepsy-linked NaV1.2 sodium channels substantially more strongly than purified CBDA alone. Researchers said the enhanced effect may result from interactions among multiple compounds in the extract, supporting further study of cannabis preparations as potential multicomponent treatments for disorders involving abnormal neuronal activity.
THC-CBD Formulation Reduces Agitation in Dementia Patients, With Nearly 90% Showing Improvement
A randomized, double-blind Phase II clinical trial involving 120 dementia patients found that an oral THC-CBD formulation significantly reduced agitation compared with placebo. After 12 weeks, 87.2% of patients receiving THC and CBD showed overall behavioral improvement, compared with 23.6% of those receiving placebo.
THC Improves Memory and Reduces Alzheimer’s-Related Brain Changes
THC improved memory performance and reduced several Alzheimer’s-related brain changes in a rat model of cognitive decline. Treatment also increased markers associated with neurogenesis and neuronal health while reducing amyloid precursor protein and phosphorylated tau, although human studies are needed to determine whether similar benefits occur in people.
Researchers Develop Low-Cost Method for Measuring CBD
Researchers developed a simple, low-cost method for measuring CBD concentrations using UV-Vis spectrophotometry rather than high-performance liquid chromatography. The technique demonstrated strong linearity and precision, potentially providing smaller laboratories and research centers with a more accessible method for quantifying total CBD.
CBG Improves Kidney Lipid Metabolism Following a High-Fat, High-Sugar Diet
CBG reduced kidney fat accumulation and improved lipid metabolism in rats fed a high-fat, high-sugar diet. Researchers found that CBG shifted kidney metabolism toward increased fatty acid breakdown and reduced fat production, suggesting potential protection against early lipid-related kidney damage associated with metabolic disorders.
Cannabis Seed Compounds May Protect Nerve Cells From Parkinson’s-Related Damage
Compounds found in cannabis seeds protected human nerve cells from Parkinson’s-related damage in laboratory experiments. The compounds reduced cell death, improved mitochondrial function and promoted autophagy, a cellular process that helps remove damaged proteins and other material.
CBD Produces Memory Improvements Comparable to Estrogen Therapy in Menopause Model
CBD improved memory in a rat model of menopause-related cognitive decline, producing effects comparable to estrogen therapy. Both CBD and estradiol completely reversed impairments in fear-related memory, while CBD also increased hippocampal levels of the endocannabinoids anandamide and 2-AG.
CBD Supplementation May Strengthen Honeybee Immune Defenses
CBD supplementation favorably altered the immune-related proteolytic system on the surface of honeybees, potentially helping maintain their defenses as they age. Researchers found increased activity of several protective enzymes and inhibitors in CBD-treated bees, with the effects strongest when CBD was administered in sugar syrup.
Clinical Trial: CBD Linked to Reduced Pain and Inflammation in Patients With Recurrent Pericarditis
A Phase 2 clinical trial involving 27 adults with recurrent pericarditis found that pharmaceutical CBD was associated with substantial reductions in chest pain and systemic inflammation. Average pain scores fell from 5.8 to 2.1 after eight weeks, and 71% of patients who entered an extension period remained free of recurrence while other pericarditis medications were tapered or discontinued.
CBD-Loaded Nanoparticles Show Promise as Potential Alzheimer’s Treatment
CBD-loaded nanoparticles designed to cross the blood-brain barrier improved memory and learning while reducing brain inflammation, amyloid-beta and tau pathology in preclinical models of Alzheimer’s disease. The targeted formulation also increased CBD transport across a blood-brain barrier model by 65% compared with non-targeted CBD nanoparticles.
CBD May Help Protect Against Traumatic Brain Injury-Related Cell Death
CBD significantly reduced ferroptosis, an iron-regulated form of cell death associated with traumatic brain injury, in rat and cell models. Researchers identified the miR-320-3p/Negr1/ERK signaling pathway as a key mechanism behind CBD’s apparent neuroprotective effects.
Topical CBD Linked to Reduced Localized Pain in Fibromyalgia Patients
A 12-week study involving 30 women with fibromyalgia found that a CBD-containing topical formulation was associated with significant reductions in localized pain and improvements in functionality. By the end of the study, 60% of participants achieved a clinically meaningful reduction in localized pain, with no adverse events reported.
Cannabis and Music May Work Together to Improve Mood and Emotional Well-Being
A survey of 122 cannabis consumers found that combining cannabis with music was frequently associated with enhanced relaxation, improved mood and stronger feelings of emotional connection. Researchers said cannabis and music may function as complementary tools for emotional well-being, although overall music reward scores did not differ significantly with and without cannabis.
Review Finds CB1 Signaling May Connect Stress, Sleep and Eating Behavior
A scientific review found that CB1 receptor signaling may serve as a biological link connecting stress, sleep, appetite, reward processing and energy metabolism. Researchers proposed that changes in endocannabinoid activity caused by stress or disrupted sleep could influence hunger, food preferences and vulnerability to metabolic problems.
Illegal Market Could Offset 89% of Decline in Legal Marijuana Consumption From Higher Prices
A study involving 1,525 marijuana consumers found that higher legal marijuana prices may substantially shift consumption to the illegal market. Researchers estimated that a 10% increase in legal marijuana prices would reduce THC consumption from legal products by about 33.5 milligrams while increasing consumption from illegal flower by 29.7 milligrams, offsetting roughly 89% of the decline.
CBD and Chemotherapy Combination Shows Antidepressant-Like Effects in Glioblastoma Study
CBD combined with the chemotherapy drug temozolomide produced antidepressant-like effects in male rats, including reduced immobility and increased climbing compared with temozolomide alone. The effect was not statistically significant when males and females were analyzed together, and the study involved healthy rats without glioblastoma.
Hemp Seed Protein Treatment May Reduce Muscle Loss and Improve Strength
Hemp seed protein hydrolysates helped prevent muscle loss and improve strength in cell and mouse models of muscle atrophy. In mice, the treatment increased grip strength and muscle mass, with researchers reporting stronger effects than those produced by whey protein.
THC Slowed Weight Loss and Prolonged Survival in Animal Model of Anorexia
THC significantly slowed additional weight loss and prolonged survival in female rats after substantial weight loss had already developed in an activity-based model of anorexia nervosa. The effect appeared to result primarily from reduced excessive physical activity and energy expenditure rather than increased food consumption.
Cannabis-Infused Tea Increased Happiness Scores in Human Study
A study involving 30 adults found that drinking cannabis-infused tea daily for one week was associated with increased happiness scores, with the 7% cannabis formulation producing the largest improvement. No adverse reactions were reported, although the small study lacked a placebo or non-cannabis control group.
CBD and CBG May Help Protect Skin Cells From UVA-Related Damage
A study published in Antioxidants found that CBD and CBG may help protect skin cells from damage caused by UVA radiation. Researchers said the cannabinoids helped reduce oxidative stress, inflammatory signaling and related cellular damage in normal melanocytes and melanoma cells.
THC and CBD May Help Reduce HIV-Related Neuroinflammation
A study published in the Journal of Neuroimmune Pharmacology found that THC and CBD may help reduce inflammatory processes tied to HIV-associated neurocognitive disorders. Researchers from Michigan State University found both cannabinoids reduced several inflammatory mediators linked to neuroinflammation in a cell-based model.
Highly Purified CBD Shows Antipsychotic-Like Effects in Mice
A study published in the Journal of Psychopharmacology found that a highly purified form of CBD showed antipsychotic-like effects in mice. Researchers compared the treatment with newer non-dopamine-blocking psychosis medications, finding CBD produced effects in two standard preclinical models relevant to psychosis.
Recreational Marijuana Legalization Linked to Lower Personal Bankruptcy Rates
A study published in Finance Research Letters found that recreational marijuana legalization was associated with lower personal bankruptcy rates. Researchers analyzed data from all 50 states and Washington, D.C., from 2001 to 2024, finding legalization was linked to about 38 fewer bankruptcy filings per 100,000 residents each year.
Inhaled Medical Cannabis Linked to Five-Year Pain Relief and Major Opioid Reduction
A study published in Biomedicines found that inhaled medical cannabis was associated with sustained improvements in pain and function over five years among patients with treatment-resistant chronic low back pain. Researchers also found opioid use dropped from 100% of patients at baseline to 4.6% after five years.
CBD-Loaded Cellulose Aerogels Show Antibacterial Activity Against H. pylori
A study published in The Journal of Supercritical Fluids found that CBD-loaded cellulose aerogels showed antibacterial activity against Helicobacter pylori. Researchers said the biodegradable delivery system gradually released CBD under gastric-like conditions, suggesting potential for further study in stomach-related bacterial infections.
Low-THC, High-CBD Extract May Reduce Cocaine Relapse
A study published in Brain Sciences found that a low-THC, high-CBD cannabis extract reduced relapse-like behavior in mice by disrupting cocaine-associated memories. Researchers said the extract reduced both cocaine-primed and stress-induced reinstatement, while showing no reinforcing or aversive effects on its own.
Automated Method Detects Pesticides in Cannabis Flower
A study published in Analytica Chimica Acta found that an automated and miniaturized testing method can detect pesticide residues in cannabis flower while using far less material than conventional approaches. Researchers said the method improved recovery rates, reduced solvent use and offered a more sustainable option for cannabis testing laboratories.
Cannabis Terpenes Enhance THC’s Activation of Cannabinoid Receptors
A study published in Biochemical Pharmacology found that several cannabis terpenes enhanced THC’s activation of CB1 and CB2 receptors in a cell-based model. Researchers said some terpenes produced additive or synergistic effects, supporting further study of how cannabis compounds may work together.
Women of Childbearing Age View Marijuana as Relatively Safe During Pregnancy
A study published in the Journal of Cannabis Research found that many women of childbearing age view marijuana as relatively safe during pregnancy, especially for symptoms such as nausea, anxiety, sleep issues and pain. Among participants who had previously been pregnant, 25.9% reported using marijuana during pregnancy.
Cannabis-Based Products Linked to Significant Seizure Reduction in Refractory Epilepsy
A study published in Clinical Therapeutics found that cannabis-based products were associated with substantial seizure reductions among patients with refractory epilepsy treated through Brazil’s public health system. Overall, 70.3% of patients reported at least a 50% reduction in seizure frequency.
CBD-Loaded Cellulose Aerogels Show Antibacterial Activity Against H. pylori
A study published in The Journal of Supercritical Fluids found that CBD-loaded cellulose aerogels showed antibacterial activity against Helicobacter pylori. Researchers said the biodegradable delivery system gradually released CBD under gastric-like conditions, suggesting potential for further study in stomach-related bacterial infections.
THC Buccal Spray Shows Promise for Treatment-Resistant Chronic Pain
A study published in the European Journal of Pharmaceutics and Biopharmaceutics found that a THC-based buccal spray may help patients with treatment-resistant chronic pain. In a small observational study, mean pain scores fell from 8.6 to about 5.4, with 83% of patients reporting at least a 20% reduction in pain.
Inhaled Medical Cannabis Linked to Five-Year Pain Relief and Major Opioid Reduction
A study published in Biomedicines found that inhaled medical cannabis was associated with sustained improvements in pain and function over five years among patients with treatment-resistant chronic low back pain. Researchers also found opioid use dropped from 100% of patients at baseline to 4.6% after five years.
Highly Purified CBD Shows Antipsychotic-Like Effects in Mice
A study published in the Journal of Psychopharmacology found that a highly purified form of CBD showed antipsychotic-like effects in mice. Researchers compared the treatment with newer non-dopamine-blocking psychosis medications, finding CBD produced effects in two standard preclinical models relevant to psychosis.
CBD and CBG May Help Protect Skin Cells From UVA-Related Damage
A study published in Antioxidants found that CBD and CBG may help protect skin cells from damage caused by UVA radiation. Researchers said the cannabinoids helped reduce oxidative stress, inflammatory signaling and related cellular damage in normal melanocytes and melanoma cells.
CBD-Loaded Nanoparticles Improved Survival in Radiation-Damaged Mice
A study published in Materials Today Bio found that CBD-loaded nanoparticles showed radioprotective effects in mice exposed to gamma radiation. Researchers said the system released CBD after radiation exposure, reduced oxidative stress and increased the 30-day survival rate of irradiated mice to over 50%.
CBD and L-Theanine Combination May Improve Caffeine-Disrupted Sleep
A study published in Biomolecules & Therapeutics found that a combination of CBD and L-theanine improved sleep-related outcomes in mice with caffeine-induced sleep disruption. Researchers said the combination reduced the time it took mice to fall asleep, increased sleep duration and affected serotonin, melatonin and GABA levels.
High-Dose CBD Linked to Increased Testosterone in Men
A human study published in Medical Cannabis and Cannabinoids found that short-term, high-dose CBD use was associated with increased testosterone levels in men. Researchers said testosterone rose 1.44-fold compared to placebo, though levels remained within normal physiological ranges and the study involved just 12 healthy adults.
Cannabinoids and Melatonin May Help Cisplatin Fight Bone Cancer Cells
A study published in Naunyn-Schmiedeberg’s Archives of Pharmacology found that cannabinoids combined with melatonin and cisplatin enhanced anti-cancer effects against certain bone cancer cells. Researchers said several combinations showed synergy, allowing for lower cisplatin doses while increasing markers of cancer cell death.
CBD Reduced Brain Injury and Cognitive Deficits Following TBI
A study published in Cellular & Molecular Biology Letters found that CBD reduced brain injury and cognitive deficits caused by traumatic brain injury in cell and mouse models. Researchers said CBD appeared to reduce ferroptosis, a form of cell death tied to iron-dependent oxidative stress.
CBD May Reduce Neuropathic Pain by Targeting Brain Region Linked to Pain and Emotion
A study published in Psychopharmacology found that CBD reduced neuropathic pain, anxiety-like behavior and depression-like behavior in rats when administered into the anterior insular cortex. Researchers said CBD’s effects appeared to involve both CB1 and serotonin 5-HT1A receptors.
Medical Cannabis Products Linked to Improved Anxiety, Sleep and Quality of Life in Autistic Adults
A study published in Neuropsychopharmacology Reports found that cannabis-based medicinal products were associated with improvements in anxiety, sleep and quality of life among autistic adults. Researchers analyzed 130 patients in the UK Medical Cannabis Registry, with improvements reported over an 18-month period.
THC-CBD Treatment Reduced Restless Legs Syndrome Severity
A study published in the Journal of Neurology found that a treatment containing 2.7 mg of THC and 2.5 mg of CBD reduced restless legs syndrome severity. Researchers said improvements were seen after one and three months, with two-thirds of participants remaining on treatment after one year.
CBD Mouthwash May Help Control Dental Biofilm Without Damaging Enamel
A study published in Clinical Oral Investigations found that CBD-based mouthwash may help control dental biofilm without damaging enamel. Researchers said a 0.05% CBD formulation showed the strongest overall potential, with biofilm control similar to chlorhexidine while avoiding some enamel-related drawbacks.
CBD Shows Potential Against Non-Small Cell Lung Cancer
A preclinical study published in Phytomedicine found that CBD may have potential as an adjunct treatment for non-small cell lung cancer. Researchers found CBD reduced cancer cell viability, triggered cancer cell death pathways and enhanced the anti-cancer effects of paclitaxel in cell and mouse models.
Biostimulants May More Than Double Cannabis Flower Yield
A study published in Frontiers in Plant Science found that certain biostimulant blends may significantly increase cannabis flower yield. Researchers found one blend increased yield by 1.17-fold, while another more than doubled yield and also increased flower size and total terpene content.
CBD Shows Potential as Long-Lasting Local Anesthetic
A study published in Anesthesia & Analgesia suggests CBD may have potential as a long-lasting local anesthetic or as an add-on to existing anesthetics. Researchers found CBD inhibited sodium channels involved in pain signaling, with slow onset and offset kinetics that may be useful for longer-lasting regional anesthesia.
Oral CBD May Help Lower Blood Pressure
A systematic review published in the Journal of Cannabis Research found that oral CBD may help reduce blood pressure in adults, particularly during stress and sleep. The review included four randomized controlled trials involving 120 participants, with all four reporting reductions in systolic blood pressure compared to placebo.
CBG and CBC Induce Cell Death in Lung Cancer Cells
A study published in Antioxidants found that CBG and CBC induced cell death and apoptosis in two lung cancer cell lines. Researchers said the findings suggest the cannabinoids may warrant further study as potential add-on cancer therapies, though the results remain limited to cell models.
Medical Marijuana Laws Linked to Fewer Health-Related Workplace Absences
A study published in the Journal of Workplace Behavioral Health found that medical marijuana laws were associated with fewer health-related workplace absences. Researchers analyzed data from more than 20 million working adults, finding medical marijuana decriminalization reduced the likelihood of health-related absences by about 6.9%.
Full-Spectrum Cannabis Oil Reduced Anesthetic Needs in Dogs
A study published in Veterinary Research Communications found that full-spectrum cannabis oil containing CBD and THC reduced anesthetic requirements in dogs undergoing cancer-related surgery. Dogs given the oil required substantially less propofol and lower concentrations of sevoflurane, with no reported adverse events during treatment or the immediate post-anesthetic period.
Cannabis Use Linked to Reduced Opioid Use Among People Managing Withdrawal
A study published in the Journal of Cannabis Research found that people who used cannabis to manage opioid withdrawal were more likely to report reduced opioid use. The association was especially strong among participants with moderate to severe pain, who had more than six times higher odds of reporting reduced opioid use.
CBD-Rich Nanoemulsion Reduced Testicular and Hormonal Damage in Animal Model
A study published in Reproductive Toxicology found that a CBD-rich nanoemulsion reduced testicular and hormonal damage caused by prenatal valproic acid exposure in rats. Researchers said the treatment helped reverse morphometric, hormonal and oxidative changes, while also normalizing antioxidant enzyme activity.
Cannabis Oils Linked to Improved Quality of Life in Horse With Severe Chronic Disease
A case report published in Frontiers in Veterinary Science found that THC- and CBD-rich cannabis oils were associated with improved comfort, appetite, mobility and wound healing in a severely ill horse receiving palliative care. Researchers said the treatment was linked to improved quality of life over most of the 10-month treatment period.
Just 31% of Consumer CBD Products Meet Label-Accuracy Standard
A review published in Phytochemistry Letters found that just 31.3% of 937 consumer CBD products tested in peer-reviewed studies met a common label-accuracy standard. Researchers said the findings point to ongoing quality-control concerns, with some products also containing THC, synthetic cannabinoids, heavy metals, pesticides or residual solvents.
Medical Cannabis Linked to Improvements in Parkinson’s Patients
A study published in Cannabis and Cannabinoid Research found that medical marijuana use was associated with improvements in pain, sleep, quality of life and nighttime urinary frequency among patients with Parkinson’s disease. Researchers said the open-label findings are exploratory and that randomized trials are needed.
CBD May Help Address “Digital Era Fatigue”
A review published in CNS and Neurodegenerative Targets – Discovery On Target suggests CBD may have therapeutic potential for addressing “Digital Era Fatigue,” a condition tied to excessive screen time and social media use. Researchers said CBD may help regulate stress, mood, sleep and cognitive resilience, though direct clinical research remains limited.
Cannabis Root Nanoparticles Show Promise in Protecting Skin Cells From UVB Damage
A study published in the International Journal of Cosmetic Science found that nanoparticles derived from cannabis root cultures may help protect skin cells from UVB-related damage. Researchers found the particles improved cell viability, reduced oxidative stress and supported skin barrier-related genes in human keratinocyte cells.
Medical Cannabis Extracts Improved Cancer-Related Symptoms in About Half of Patients
A randomized, placebo-controlled, triple-blind clinical trial found that medical cannabis extracts provided meaningful relief for cancer-related symptoms in about half of patients. Researchers said improvements were most tied to sleep, anxiety and daytime tiredness, with no single extract clearly outperforming the others.
Cannabis Leaves Could Be Valuable Source of Antioxidant Compounds
A study published in Molecules found that cannabis leaves, often discarded as cultivation waste, could be a valuable source of antioxidant phenolic compounds. Researchers found that ultrasound-assisted extraction recovered high levels of phenolic compounds and flavonoids much faster than conventional maceration.
Hemp Seed Oil Nanoemulgel Shows Promise for Treating Psoriasis
A study published in the International Journal of Biological Macromolecules found that a hemp seed oil-based nanoemulgel significantly reduced inflammation in an animal model of psoriasis. Researchers said the formulation may help stabilize hemp seed oil delivery while preserving its functional properties.
CBD-Hesperetin Formulation Greatly Improves CBD Solubility
A study published in AAPS PharmSciTech found that a specialized CBD-hesperetin formulation dramatically improved CBD’s solubility, dissolution and in vitro permeability. Researchers said the hot-melt extrusion approach may offer a promising delivery platform for poorly soluble compounds such as CBD.
Cannabinoid-Based Therapies Linked to Reduced Agitation in Alzheimer’s Patients
A systematic review and meta-analysis published in The American Journal of Geriatric Psychiatry found that cannabinoid-based therapies were associated with reduced agitation and neuropsychiatric symptoms in Alzheimer’s patients. Researchers said drowsiness was the main safety concern, and larger randomized trials are needed.
Pediatric THC-Positive ER Drug Screens in Illinois Did Not Increase After Legalization
A study published in The Western Journal of Emergency Medicine found that recreational marijuana legalization in Illinois was not associated with a significant increase in pediatric emergency department patients testing positive for THC. Researchers reviewed pediatric urine drug screens before and after legalization, finding THC-positive screens rose only slightly from 18.18% in 2019 to 20.99% in 2020, a difference that was not statistically significant.
Robotic Testing Method Enables Rapid Screening of Pesticides in Cannabis Flower
A study published in Talanta found that a robotic testing platform paired with UHPLC-MS/MS can rapidly screen cannabis flower for pesticide residues using a smaller, more sustainable process. Researchers developed a method requiring just 30 mg of dried cannabis and 200 μL of acetonitrile, with a full analysis time of 25 minutes per sample.
Inhaled CBD Reversed Seizure and Inflammation-Related Effects of Chronic Nicotine Exposure
A study published in Experimental Lung Research found that inhaled CBD reversed several seizure-related and inflammatory effects linked to chronic nicotine pouch exposure in mice. Researchers found nicotine exposure worsened seizure severity and disrupted inflammatory markers, while inhaled CBD reduced seizure severity and helped normalize those effects.
Medical Cannabis Linked to Long-Term Improvements in Hypermobility-Related Chronic Pain
A study published in Clinical Rheumatology found that cannabis-based medicinal products were associated with sustained improvements in pain, anxiety and sleep among patients with hypermobility-associated chronic pain. Researchers analyzed 240 patients in the UK Medical Cannabis Registry, finding clinically significant improvements in pain severity and pain interference after 24 months.
Review Highlights Endocannabinoid System’s Role in Muscle Health and CBD’s Therapeutic Potential
A review published in Molecular Metabolism highlights the endocannabinoid system’s role in skeletal muscle health and CBD’s potential therapeutic relevance. Researchers examined how endocannabinoid signaling influences muscle development and function, noting its possible connection to conditions including obesity, type 2 diabetes, sarcopenia, cachexia and muscular dystrophies.
CBD Reduced Lung Injury by Targeting Inflammation, Oxidative Stress and Cell Death Pathways
A study published in the Iranian Journal of Basic Medical Sciences found that CBD helped protect against lung ischemia-reperfusion injury in rats. Researchers found CBD reduced markers of inflammation, apoptosis and necroptosis, while increasing antioxidant activity, suggesting potential therapeutic value for this type of lung injury.
Adolescent Delta-8 Use Remained Unchanged Even as Marijuana Use Fell
A study published in the American Journal of Preventive Medicine found that while marijuana use among U.S. 12th graders declined from 2023 to 2024, delta-8 THC use remained statistically unchanged. Researchers found past-year marijuana use fell from 30.4% to 25.5%, while delta-8 use remained around 12%.
