420 Peer-Reviewed Cannabis Studies, All Published in 2025

Cannabis-Based Medicines Improve Quality of Life in Patients With Treatment-Resistant Epilepsy

Published in Medical Cannabis and Cannabinoids, this study found that patients with treatment-resistant epilepsy reported improvements in physical functioning, emotional well-being, and overall quality of life after using cannabis-based medicines. Many also experienced fewer seizures and reduced reliance on other medications.

CBD Strengthens Peyer’s Patch Barrier, Suggesting Potential to Help Prevent Gut Inflammation

Published in Pharmaceuticals, this study found that cannabidiol (CBD) strengthened the epithelial barrier in Peyer’s patches, a key immune component of the gut. In mouse models, CBD reduced gut permeability and inflammation, indicating potential for treating or preventing inflammatory bowel conditions.

Cannabinerol (CBNR) May Counteract Alzheimer’s-Related RNA Splicing Defects

Published in International Journal of Molecular Sciences, this study found that the rare cannabinoid cannabinerol (CBNR) restored normal RNA splicing in cell models affected by Alzheimer’s-related mutations. CBNR reversed gene expression abnormalities and showed potential as a therapeutic agent targeting molecular causes of neurodegeneration.

Cannabinoids May Help Treat Glaucoma-Related Neurodegeneration Through Multitargeted Effects

Published in Cells, this study reviewed the potential of cannabinoids to protect against glaucoma-related neurodegeneration. The authors identified multiple mechanisms, including intraocular pressure reduction, anti-inflammatory action, and neuroprotective effects, supporting the idea that cannabinoids may offer a comprehensive treatment approach for glaucoma.

Largest-Ever Meta-Analysis of Medical Cannabis Finds Overwhelming Scientific Consensus for Treating Cancer Symptoms

Published in Frontiers in Pain Research, this meta-analysis of 43 studies concluded that medical cannabis is widely effective in managing cancer-related symptoms, especially pain, nausea, appetite loss, and sleep disturbances. The findings reflect a strong scientific consensus supporting cannabis as a safe and beneficial supportive therapy for cancer patients.

Cannabis Leaves Improve Taste and Quality of Kombucha by Enhancing Fermentation

Published in Foods, this study found that adding cannabis leaves to kombucha improved its flavor, antioxidant levels, and fermentation efficiency. The cannabis-enhanced kombucha showed higher levels of beneficial compounds and better sensory scores compared to control samples, suggesting added nutritional and commercial value.

Cannabis Callus Extract Shows Promise as Anti-Inflammatory and Antioxidant Cosmetic Ingredient

Published in Pharmaceuticals, this study demonstrated that cannabis callus extract exhibited strong antioxidant and anti-inflammatory effects in human skin cell models. The extract significantly reduced oxidative stress and inflammatory markers, supporting its potential use in skincare formulations for soothing and protective benefits.

Cannabis Stem Nanoparticles May Help Treat Skin Pigmentation and Protect Against Oxidative Stress

Published in Antioxidants, this study found that nanoparticles derived from cannabis stems reduced melanin production and oxidative stress in human skin cells. The particles also showed no cytotoxic effects, highlighting their promise as a natural, safe ingredient for treating hyperpigmentation and protecting skin from environmental damage.

Cannabis Use Linked to Reduced Stress and Improved Sleep in Veterans, Unlike Alcohol

Published in Clinical Toxicology, this study found that veterans who used cannabis reported lower stress, better sleep, and improved coping compared to those who used alcohol. The results suggest that cannabis may offer a healthier alternative for stress management without the negative mental health effects associated with alcohol use.

Nanoparticles Derived From Cannabis Leaves Show Strong Antibacterial and Antioxidant Properties

Published in Applied Nanoscience, this study found that silver nanoparticles synthesized using cannabis leaf extract exhibited strong antibacterial effects against multiple pathogens and showed significant antioxidant activity. These results highlight the potential of cannabis-based nanoparticles for biomedical and environmental applications.

Sublingual CBD Improves COVID-19 Outcomes

Published in Cureus, this study found that hospitalized COVID-19 patients who received sublingual cannabidiol (CBD) experienced shorter recovery times, reduced inflammation, and lower rates of ICU admission compared to a control group. The results suggest CBD may have therapeutic value in managing severe viral infections.

CBD Reduces Stress-Induced Liver Damage by Improving Mitochondrial Function and Reducing Inflammation

Published in Biomedicine & Pharmacotherapy, this study found that cannabidiol (CBD) protected against liver damage caused by chronic stress in mice. CBD improved mitochondrial function, reduced oxidative stress, and suppressed inflammation, leading to significant improvements in liver health.

CBD-Loaded Niosomes Show Promise for Retinal Protection in Groundbreaking New Study

Published in Antioxidants, this study found that CBD encapsulated in niosomes effectively protected retinal cells from oxidative stress and degeneration in animal models. The delivery system enhanced CBD stability and bioavailability, making it a promising strategy for treating degenerative eye diseases.

THC/CBD Extract May Reduce Inflammation, Improve Movement After Spinal Cord Injury

Published in Pharmaceuticals, this study found that a THC and CBD extract reduced neuroinflammation and promoted motor function recovery in rats with spinal cord injury. The treatment also preserved nerve tissue and reduced pain sensitivity, indicating therapeutic potential for spinal trauma.

Newly Discovered Cannabinoids From Cannabis Flowers Show Antitumor Potential Against Neuroblastoma

Published in Pharmaceuticals, this study identified eleven previously unknown compounds from cannabis flowers, several of which demonstrated significant anti-tumor activity against neuroblastoma cells. Two cannabinoids showed especially strong inhibition of cancer cell viability, suggesting potential for future cancer treatments.

Inhalable CBD Powder Formulated With Methyl-β-Cyclodextrin Shows Superior Delivery Performance

Published in AAPS PharmSciTech, this study found that an inhalable cannabidiol (CBD) powder formulated with methyl-β-cyclodextrin achieved high solubility, stability, and bioavailability. The powder maintained its amorphous state under humid conditions and showed promise as a fast-acting delivery system for pulmonary administration.

Cannabis Use Associated With Reduced Opioid Use in Patients With Chronic Pain and Anxiety

Published in Medical Cannabis and Cannabinoids, this study found that chronic pain patients who used medical cannabis were significantly more likely to reduce or stop opioid use, especially among those with co-occurring anxiety. Participants reported better pain management and improved mental health outcomes with cannabis treatment.

CBD May Improve Sleep Patterns Disrupted by Anesthesia

Published in Biomedicine & Pharmacotherapy, this study found that cannabidiol (CBD) helped restore normal sleep-wake cycles in mice after anesthesia-induced disruption. CBD treatment improved both the quality and timing of sleep, suggesting potential benefits for post-surgical recovery and circadian rhythm regulation.

CBD Found to Significantly Reduce Seizures Across Multiple Forms of Drug-Resistant Epilepsy in New Study

Published in The Lancet Neurology, this study found that cannabidiol (CBD) significantly reduced seizure frequency in patients with various types of drug-resistant epilepsy. Participants experienced meaningful improvements in seizure control, with many reporting a greater than 50% reduction during treatment.

CBD-Loaded Nanoparticles Show Potential for Treating Metabolic Disorders

Published in Nanomedicine: Nanotechnology, Biology and Medicine, this study found that CBD-loaded nanoparticles improved glucose metabolism, reduced inflammation, and enhanced mitochondrial function in a mouse model of metabolic syndrome. The targeted delivery system increased CBD’s bioavailability and therapeutic impact.

Marijuana Legalization Not Linked to Increase in Car Accident Fatalities, Insurance Claims, or Average Claim Cost

Published in Health Economics, this study analyzed auto insurance and fatal crash data following marijuana legalization in multiple U.S. states. Researchers found no evidence that legalization led to higher accident fatality rates, increased claims, or higher average costs per claim, countering concerns about cannabis-related road risk.

Medical Cannabis Improved PTSD Symptoms, Anxiety, and Quality of Life Over an 18-Month Period

Published in Expert Review of Neurotherapeutics, this long-term study found that medical cannabis significantly reduced PTSD symptoms, anxiety, and sleep disturbances in patients over an 18-month period. Most participants also reported improved overall quality of life and a decrease in the use of psychiatric medications.

Cannabis-Based Treatments Significantly Reduce Tics in Adults With Tourette Syndrome

Published in Cannabis and Cannabinoid Research, this study found that THC-based treatments significantly reduced motor and vocal tics in adults with Tourette syndrome. The majority of patients experienced clinical improvement with minimal side effects, suggesting cannabis as a viable therapeutic option.

THCV Found to Help Regulate Appetite and Glucose in Obesity and Diabetes Models

Published in Biomedicine & Pharmacotherapy, this study found that tetrahydrocannabivarin (THCV) reduced food intake, body weight, and blood glucose levels in animal models of obesity and type 2 diabetes. THCV also improved insulin sensitivity, suggesting it may have therapeutic potential for metabolic disorders.

Cannabis Extracts Rich in CBC and THC Found to Kill Bladder Cancer Cells

Published in Current Oncology, this study found that cannabis extracts containing high levels of cannabichromene (CBC) and tetrahydrocannabinol (THC) induced apoptosis and inhibited the growth of bladder cancer cells in vitro. The results support further investigation into these cannabinoids for cancer therapy.

Far-Red Light Boosts In Vitro Marijuana Growth and Shoot Yield, Clemson Researchers Find

Published in Plants, this Clemson University study found that far-red light enhanced the in vitro growth of marijuana plants, increasing both shoot number and biomass. The results suggest that far-red supplementation can optimize micropropagation techniques for cannabis cultivation.

Cannabidiol Found Safe and Effective for Children With Drug-Resistant Epilepsy

Published in Children, this study found that cannabidiol (CBD) was well tolerated and significantly reduced seizure frequency in children with drug-resistant epilepsy. Caregivers also reported improvements in sleep, alertness, and behavior, supporting the use of CBD in pediatric epilepsy treatment.

Cannabidiol (CBD) Therapy Could Reduce Symptoms in Autistic Children and Teenagers, Finds Study

Published in Scientific Reports, this study found that CBD-rich cannabis extracts improved behavioral symptoms, social interaction, and sleep quality in children and adolescents with autism spectrum disorder. The treatment was generally well tolerated, with few mild side effects reported.

Clinical Trial: CBD Improves Naming Function in People With Parkinson’s Disease

Published in Journal of Psychopharmacology, this randomized clinical trial found that cannabidiol (CBD) improved verbal fluency—specifically naming function—in patients with Parkinson’s disease. The results suggest cognitive benefits in addition to CBD’s previously noted effects on mood and motor symptoms.

Government-Funded Study Finds Hemp Crude Oil Shows Antimicrobial Effects Against Bacteria Linked to Cattle Liver Abscesses

Published in Frontiers in Microbiology, this USDA-funded study found that hemp crude oil inhibited the growth of Fusobacterium necrophorum and Trueperella pyogenes, two bacteria that contribute to liver abscesses in cattle. The findings suggest hemp oil could be a natural alternative to antibiotics in livestock management.