420 Peer-Reviewed Cannabis Studies, All Published in 2025

Controlled Trial: CBD/CBDA Paste Reduces Osteoarthritis Pain in Cats

A randomized, placebo-controlled trial in felines with osteoarthritis found that a paste containing both CBD and CBDA improved mobility scores, reduced pain-related behaviors and was well tolerated; potential implications extend to companion-animal and human OA therapy.


Study: CBD Shows Potential for Treating Cardiovascular Disease

Preclinical cardiology research revealed that CBD improved endothelial function, reduced myocardial inflammation and attenuated hypertrophy in disease models—suggesting it may offer a complementary approach to cardiovascular treatment.


Study: Wastewater Analysis Finds Cannabis Use Rising in Japan With CBD Use Far More Prevalent

Municipal wastewater surveillance in Japan detected increases in cannabis biomarkers, particularly CBD metabolites, indicating shifting consumption patterns and possible growth in non-psychoactive cannabis product use.


Study: Mitochondrial Cannabinoid Receptors Play Key Role in Skeletal Muscle Health and Function

Research identified mitochondrial CB1/CB2 receptors in skeletal muscle cells as regulators of mitochondrial biogenesis and muscle performance; modulation by cannabinoids suggests a new avenue for muscle health interventions.


Study: Cannabis Extract Shows Pain-Relieving, Anti-Inflammatory and Anti-Dysmenorrheal Effects

Women experiencing primary dysmenorrhea treated with a standardized cannabis extract reported reduced pain severity, less inflammation and improved daily function, pointing to cannabis’ potential in menstrual health management.

Study: Cannabis Use Linked to Reduced Fatigue and Cognitive Symptoms in MS and Parkinson’s Patients, Finds Study

In patients with Multiple Sclerosis and Parkinson’s Disease, self-reported cannabis use was associated with lower fatigue scores, less emotional variability, and better cognitive performance, suggesting a beneficial effect on non-motor symptoms in these populations.


Study: Novel Electrochemical Sensor Offers Rapid Selective Detection of CBD and THC

Researchers developed a molecular-imprinted platinum-iridium‐alloy electrode capable of distinguishing Cannabidiol (CBD) from Tetrahydrocannabinol (THC) using oxidation potentials, achieving detection limits of ~1.2 µM for CBD and ~1.7 µM for THC, demonstrating a promising tool for rapid quality control in cannabis products.


Study: Age, Sex and Carrier Oil All Influence How Vaping Marijuana Affects the Body, Study Shows

In a human trial examining vaping cannabis, researchers found that pharmacokinetic and effect profiles varied significantly by participant age, biological sex, and the type of carrier oil used in the vaping formulation—highlighting the need for personalized dosing and formulation considerations.


Study: Recreational Marijuana Legalization Linked to Fewer Opioid Overdose Deaths

An epidemiological study observed jurisdictions that legalized recreational cannabis had a statistically significant reduction in opioid overdose death rates over subsequent years compared to those that did not, suggesting a possible public-health benefit linked to cannabis policy.


Study: Cannabidiol Alters Gene Expression Linked to Immune Response and Cell Death in Leukemia Cells

In vitro work on leukemia cell lines showed that CBD modulated expression of genes associated with apoptosis, immune regulation, and cell-cycle control, indicating potential synergy with conventional therapies for hematologic malignancies.

Study Finds Blunt Smoking Rising Sharply Among U.S. Adults, Especially Women and Non-Drinkers

National survey data indicate a significant increase in blunt (cannabis rolled in tobacco leaf) use among U.S. adults over recent years, with the largest upticks seen among women and individuals who do not drink alcohol, raising implications for dual-use public health messaging.


Study: Irrigation Levels Influence Hemp Biomass but Not Cannabinoid Concentrations

Agronomic research on industrial hemp found that while different irrigation volumes affected overall plant biomass significantly, they did not substantially alter concentrations of key cannabinoids like CBD or THC, suggesting some flexibility in water use without compromising cannabinoid content.


CBD-Wound Healing

A preclinical assessment of cannabidiol (CBD) in wound-healing models demonstrated accelerated closure rates, reduced scarring and improved dermal regeneration compared with controls, supporting further exploration of CBD-infused dressings or topical therapies.


Study: Finds Cannabis Use Associated With Lower Odds of Common Sinonasal Diseases

Epidemiological data show that regular cannabis users had lower prevalence of chronic rhinosinusitis and related disorders compared with nonusers, though causality remains undetermined and further investigation into mechanisms is called for.


Study: Public Support for Medical Cannabis in Poland Is Above 80 % but Clinical Integration Still Lags

A national survey found over 80 % of Polish citizens support medical-cannabis access, but actual clinical implementation—including training, prescribing frameworks and reimbursement—is still significantly behind public sentiment.

Study: Industrial Hemp Supplementation Reduces Stress and Improves Antioxidant Levels in Angus Cattle

In a 35-day trial, Angus heifers fed industrial hemp showed reduced cortisol levels, higher antioxidant activity (including glutathione peroxidase), and decreased markers of oxidative stress—while digestive health remained stable.


Study: Cannabigerol May Protect Colon Health and Improve Metabolic Function Under High-Fat, High-Sugar Diet

Rats on a high-fat, high-sugar diet received cannabigerol (CBG) and showed reduced ceramide levels in the colon, improved insulin signalling and lower inflammatory cell infiltration—indicating CBG may counter diet-induced metabolic and colon damage.


Study: CBD Reduces Neuroinflammation in Alzheimer’s Model by Targeting Key Immune Pathways

In Alzheimer’s disease animal models, CBD treatment lowered immune-mediated neuroinflammation and improved cognitive read-outs, suggesting modulation of microglial and cytokine signalling as part of its mechanism.


Study: Hemp Seed Extract Reduces Obesity Markers Through AMPK Pathway

Preclinical work found that hemp-seed extract activated the AMPK signalling pathway in obese models, resulting in lower body-fat markers and improved metabolic profiles, positioning hemp seed derivatives as potential anti-obesity agents.


Study: CBD Suppresses HIV and SIV Replication and Slows Immune Decline in Preclinical Models

In lab and animal models of HIV/SIV, CBD was shown to suppress viral replication, preserve CD4+ cell counts and slow immune deterioration, offering a compelling preclinical case for adjunctive therapy in viral-immune disorders.

Clinical Trial Finds Marijuana Extract Safer and More Effective than Opioids for Chronic Low Back Pain

A phase 3 trial with 384 participants compared a full-spectrum cannabis extract (VER-01) against opioids for chronic low back pain over six months. The cannabis group had stronger pain relief, fewer bowel complications, and no withdrawal or dependence, offering a potential non-addictive alternative.


Study: THC in Cannabis Resin Nearly Disappears After Two Years of Storage, While CBN and CBD Increase

Long-term storage analysis found that THC levels in resin degrade sharply over two years, while CBN and CBD concentrations increase, underscoring the importance of storage conditions for cannabinoid stability and potency.


Study Finds Major Inaccuracies in THC Labeling of Cannabis Edibles in Mississippi

Testing of edible cannabis products revealed large discrepancies between labeled THC content and actual amounts, raising concerns about consumer safety, dosing reliability, and regulatory oversight in the marketplace.


Study: Cannabis Use Common Among Medical Students Worldwide, With Rising Trends in Recent Years

A global survey of medical students found increasing cannabis use over recent years, exploring associations with stress, sleep, and academic performance, and prompting calls for education on use versus misuse.


Study Finds CBD Reduces Anxiety and Inflammation Caused by Obesity and Aging

Experimental work showed that CBD alleviated anxiety-like behavior and decreased inflammatory markers in older obese models, suggesting therapeutic potential for age- and weight-related neuro-inflammation and mood disruptions.

Study: CBD-Loaded Microparticles Show Potential for Colorectal Cancer Treatment

Researchers developed microparticle-based delivery systems for CBD that increased tumor targeting and efficacy in colorectal cancer models, suggesting enhanced formulation strategies could improve clinical outcomes.


Study: Finds Blue-Red LED Ratios Drive Higher CBD Yield in Cannabis

A controlled cultivation study revealed that optimizing blue-to-red LED light ratios significantly increased CBD content in Cannabis sativa plants, offering growers a scalable method to improve cannabinoid yield and consistency.


Researchers Discover New Cannabinoid Cannabizetol With Remarkable Antioxidant and Skin Anti-Inflammatory Activity

A novel cannabinoid named cannabizetol was isolated and found to have strong antioxidant and anti-inflammatory effects on skin cells, opening potential applications in dermatological and cosmetic therapy.


THCV Study Finds Favorable Safety Profile, Mild THC-Like Effects at Higher Doses

A first-in-human trial of THCV demonstrated that moderate to high doses are well tolerated, with mild euphoria at higher levels and no serious adverse events, supporting further exploration of THCV’s therapeutic role.


Study: Hybrid CBD and Silver Hydrogel Shows Strong Antimicrobial Potential for Wound Care

A hybrid hydrogel combining CBD and silver nanoparticles exhibited potent antimicrobial and wound-healing activity in preclinical models, suggesting an innovative path for cannabis-derived materials in medical device and wound-care settings.

Study: CBD Reduces Heroin-Seeking Behavior by Altering Key Brain Pathways

Animal research showed CBD reduced cue-induced heroin-seeking while normalizing gene-expression changes in the nucleus accumbens, especially those tied to immune signaling, astrocyte activity, and extracellular matrix regulation.


Cannabis and Autism: Six Recent Studies Highlight CBD’s Potential Role in Reducing Symptoms and Protecting Brain Function

A review of six studies found CBD improved core and co-occurring symptoms in autism, including anxiety, irritability, and repetitive behaviors, with preclinical data suggesting additional neuroprotective effects.


Study: CBD Alzheimer’s Study

CBD reduced neuroinflammation and improved memory-related outcomes in Alzheimer’s models, strengthening evidence that it may offer a low-cost, non-invasive therapeutic avenue for neurodegenerative disease.


Study: Cannabis Polysaccharides Show Antioxidant and Anti-Aging Potential

Cannabis-derived polysaccharides demonstrated strong antioxidant activity and reduced markers of cellular aging, suggesting they may contribute to cannabis’ broader therapeutic profile.


Study: CBD Leukemia

Preclinical results showed CBD inhibited leukemia cell growth and promoted apoptosis, indicating potential supportive use of cannabinoids in certain blood cancers.

Study: Subcritical Water Extraction Offers Sustainable Alternative for Cannabinoid Recovery

Researchers demonstrated that subcritical water extraction efficiently recovers cannabinoids with lower environmental impact than conventional methods, paving the way for greener production of cannabis-derived medicines.


Study: Chlorophyll Compounds Boost CBD Bioavailability and Therapeutic Effects

The addition of chlorophyll derivatives to CBD formulations was found to enhance absorption and amplify therapeutic outcomes, suggesting a novel formulation strategy for more effective CBD therapies.


Study: Cannabis Use Linked to Lower Stress and Improved Sleep for Veterans with PTSD

Among veterans diagnosed with PTSD, cannabis use was correlated with reductions in perceived stress and improvements in sleep quality, indicating a potential supportive role for cannabis in trauma-related care.