Cannabis’s Potential in Combatting Alzheimer’s Disease
Published in IBRO Neuroscience Reports, this review highlights how cannabis-derived compounds, including both cannabinoids and non-cannabinoids, may address the complex pathology of Alzheimer’s disease. The authors emphasize the need for multi-target treatment strategies and identify cannabis as a promising area for future therapeutic development.
Cannabigerol May Treat Atopic Dermatitis by Targeting Key Inflammatory Pathways
Published in Cells, this study found that cannabigerol (CBG) may help treat atopic dermatitis by suppressing key inflammatory pathways. In cell and mouse models, CBG reduced levels of multiple pro-inflammatory cytokines and inhibited the JAK/STAT and NF-κB signaling pathways, leading to improved skin condition and stronger skin barrier function.
Full-Spectrum CBD Oil Reduces Key Markers of Muscle Damage in Duchenne Muscular Dystrophy
Published in Muscle & Nerve, this study found that full-spectrum cannabidiol (CBD) oil may help treat Duchenne muscular dystrophy (DMD). In vitro tests showed dose-dependent cytotoxic effects, but in vivo administration to mdx mice at 10 mg/kg per day for 14 days was safe and led to significant improvements in muscle pathology. The treatment reduced central nuclei, IgG+ myofibers, inflammatory areas, and fibrosis in diaphragm and quadriceps muscles, while increasing myofiber size and reducing macrophage presence and NF-κB levels. Serum creatine kinase levels, a marker of muscle damage, were also lowered.
CBD Protects Against Some of the Toxic Effects of Cadmium
Published in Basic & Clinical Pharmacology & Toxicology, this study investigated cannabidiol’s (CBD) protective effects against cadmium-induced toxicity in mice. Researchers found that CBD mitigated oxidative stress and inflammation in the liver and kidneys by restoring antioxidant markers and reducing proinflammatory cytokines. Histological analysis confirmed tissue protection in these organs, though no protective effect was observed in testicular tissue.
High-Potency Cannabis Use Linked to Improved Mood and Decreased Anxiety, No Negative Impact on Emotional Regulation
Published in Human Psychopharmacology: Clinical & Experimental, this pilot study found that acute use of high-potency cannabis improved mood and reduced anxiety in young adult users without impairing their ability to regulate emotions. Participants showed no decline in performance on emotion regulation tasks while intoxicated, suggesting mood benefits without cognitive or emotional detriment.
Psilocybin Shows Potential in Treating Repetitive Mild Head Injuries
Published as a preprint in bioRxiv, this study found that psilocybin may mitigate the effects of repetitive mild head injuries. In an animal model simulating trauma from sports, accidents, or military service, psilocybin reduced vasogenic edema, restored vascular reactivity and functional connectivity, lowered phosphorylated tau buildup, and increased levels of brain-derived neurotrophic factor (BDNF) and its receptor TrkB. These findings suggest psilocybin’s potential in addressing cognitive decline and neurodegenerative diseases associated with such injuries
CBD Induces Apoptosis and Inhibits Growth in Colorectal Cancer Cells, Regardless of Mutation
Published in ACS Pharmacology & Translational Science, this study found that cannabidiol (CBD) induces apoptosis and inhibits proliferation, migration, and invasion in colorectal cancer cell lines with various mutations, including KRAS, BRAF, APC, and PTEN. The anticancer effects were mediated through CB2 receptor activation and involved endoplasmic reticulum stress, while sparing healthy intestinal organoids.
Psilocybin Therapy May Help Those With Parkinson’s Disease Overcome Anxiety and Pessimism
Published in the Journal of Parkinson’s Disease, this case study from the University of Geneva and Geneva University Hospital explored psilocybin-assisted psychotherapy in a 43-year-old Parkinson’s patient experiencing anxiety and difficulty accepting her diagnosis. Over four high-dose sessions across a year, the patient reported reduced pessimism and anxiety, improved well-being, and greater openness to pharmacological treatment. The study suggests psilocybin therapy may aid in emotional adjustment for Parkinson’s patients, though larger trials are needed to confirm these findings.
THCV and CBD Mucoadhesive Strips Linked to Weight Loss and Metabolic Benefits
Published in Cannabis, this placebo-controlled study found that daily use of mucoadhesive strips containing tetrahydrocannabivarin (THCV) and cannabidiol (CBD) led to significant weight loss and metabolic improvements over 90 days. Participants experienced reductions in abdominal girth, systolic blood pressure, and LDL cholesterol, with the higher dose (16 mg THCV/20 mg CBD) showing greater efficacy.
Patients With Cancer Report Significant Improvements in Symptoms, But Affordability an Issue
Published in the Journal of Cannabis Research, this study surveyed 220 cancer patients enrolled in Minnesota’s medical cannabis program. While both financially comfortable and struggling patients reported significant symptom relief from cannabis use, affordability remained a major barrier. Patients facing financial hardship were more likely to spend over $200 monthly on cannabis and more likely to reduce or discontinue use due to cost, highlighting disparities in access.
Cannabidiol (CBD) Disrupts Bacterial Cell Walls, Showing Potential as an Antibiotic Alternative
Published in the Journal of Proteomics, this study found that cannabidiol (CBD) causes significant structural damage to bacterial cell walls and membranes in strains like Bacillus licheniformis, Staphylococcus aureus, and Enterococcus faecium. CBD disrupted key metabolic pathways and altered protein expression, suggesting a novel antibacterial mechanism that could serve as an alternative to traditional antibiotics.
CBD Reshapes Gut Microbiome to Enhance Endurance in Animal Model
Published in Experimental & Molecular Medicine, this study found that cannabidiol (CBD) enhances endurance exercise in mice by altering the gut microbiome and promoting muscle adaptation. CBD increased oxidative muscle fibers, mitochondrial biogenesis, and endurance-related gene expression. The study also identified Bifidobacterium animalis KBP-1 as a key microbe elevated by CBD, which independently improved running performance when administered.
Purified CBD Improved Symptoms in Over 80% of Children With Severe, Treatment-Resistant Autism
Published in Pharmacology Biochemistry and Behavior, this study found that purified cannabidiol (CBD) significantly improved behavioral symptoms in children with severe, treatment-resistant autism. Ninety percent of participants showed improvement in at least one symptom, and 40% were able to reduce or discontinue other medications. Side effects were mostly mild and temporary.
Cannabidiol Enhances Bone Marrow Recovery After Radiation Exposure
Published in MedComm, this study showed that cannabidiol (CBD) improved survival and restored bone marrow function in mice exposed to radiation. The treatment reactivated stem cell maintenance pathways by upregulating the transcription factor Atf2, suggesting CBD may have value as a radioprotective therapy.
Cannabis Essential Oil May Reduce Neuropathic Pain
Published in the Journal of Ethnopharmacology, this study found that Moroccan cannabis essential oil reduced sensitivity to pain and aided nerve function recovery in mice with peripheral neuropathy. The effects are believed to stem from compounds like (E)-caryophyllene and α-humulene.
Hot Air Drying and Glass Jar Curing Preserve Cannabinoids and Improve Hemp Safety
Published in Plants, this Cornell University study found that hot air drying at 75°C effectively reduced hemp moisture and microbial content, while glass jar curing preserved cannabinoid levels and further improved safety. The combined method was more efficient than ambient or freeze-drying approaches.
CBD Nanoemulsion May Reverse Autism-Like Behaviors and Prevent Neural Damage
Published in Annals of the Brazilian Academy of Sciences, this study showed that CBD delivered via nanoemulsion reversed autism-like behaviors and protected hippocampal neurons in a rat model of autism. The formulation improved bioavailability and led to enhanced social interaction, reduced anxiety, and better exploratory behavior.
CBD Hydrogel Microneedle Patch Has Obvious Therapeutic Effects for Psoriasis Patients
Published in the International Journal of Biological Macromolecules, this study found that a CBD-infused hydrogel microneedle patch reduced inflammation, skin thickness, and scaling in a mouse model of psoriasis. The treatment suppressed TRIM14 and NF-κB signaling, outperforming conventional topical medication.
Marijuana Stores Reduce Opioid Deaths But Do Not Increase Suicides or Car Crashes
Published in Health Economics, this federally funded study analyzed 16 years of county-level data and found that the presence of recreational marijuana stores was associated with a reduction in opioid-related deaths. Importantly, there was no evidence linking these stores to an increase in suicide rates or traffic fatalities.
CBD Reduces Lung Damage in Blunt Chest Trauma
Published in the Brazilian Journal of Medical and Biological Research, this study found that cannabidiol (CBD) reduced inflammation, oxidative stress, and tissue damage in rats after blunt chest trauma. CBD treatment lowered pro-inflammatory cytokines and improved lung structure, indicating protective effects in traumatic injury.
CBD May Help Kill Ovarian Cancer Cells by Disrupting Their Fat Metabolism
Published in Frontiers in Pharmacology, this study found that cannabidiol (CBD) may kill ovarian cancer cells by interfering with lipid metabolism, specifically reducing the expression of CPT1A, a key enzyme in fatty acid oxidation. The findings suggest that CBD could be a promising therapeutic candidate for targeting metabolic vulnerabilities in ovarian cancer.
Nanotechnology-Enhanced CBD Delivery Shows Promise for Retinal Neuroprotection
Published in Pharmaceutics, this study demonstrated that cannabidiol (CBD) delivered through a nanostructured lipid carrier hydrogel protected retinal cells from degeneration in rats. The treatment reduced inflammation and oxidative stress, and the nanocarrier improved CBD bioavailability and sustained release in the eye.
Opening Recreational Marijuana Stores Has No Impact on Emergency Room Visits
Published in Health Economics Review, this study analyzed over 4,000 emergency room visits in Colorado and found that the opening of recreational marijuana stores did not lead to increased ER visits. The results challenge assumptions that legalization leads to a surge in emergency medical incidents.
Cannabis Extract May Improve Insomnia in Parkinson’s Disease Patients
Published in Journal of Neurology, this study found that a THC/CBD cannabis extract improved sleep quality in patients with Parkinson’s disease. Participants reported fewer nighttime awakenings and improved overall restfulness, with minimal side effects, suggesting the extract may offer a promising treatment for insomnia linked to the condition.
Cannabinoid-Based Supplement Improves Sleep Quality and Health Outcomes in Adults With Subthreshold Insomnia
Published in Frontiers in Psychiatry, this randomized, placebo-controlled trial found that a cannabinoid-based supplement containing CBD and CBN significantly improved sleep quality in adults with subthreshold insomnia. Participants also reported better mental health and reduced stress levels, with no serious side effects reported over the 8-week study period.
Cannabinoids Improve Memory and Motor Function in Animal Model of Alzheimer’s Disease
Published in Molecular Neurobiology, this study found that repeated low doses of cannabinoids improved memory, cognition, and motor function in an Alzheimer’s disease mouse model. The treatment also reduced amyloid plaque levels, oxidative stress, and neuroinflammation, suggesting cannabinoids may offer therapeutic potential for neurodegenerative disorders.
Low-Dose CBD May Enhance Opioid Pain Relief Without Increasing Adverse Effects
Published in The Journal of Pain, this randomized, double-blind clinical trial found that low-dose cannabidiol (CBD) enhanced the pain-relieving effects of opioids in healthy adults exposed to pain stimuli. CBD also reduced pain unpleasantness and did not increase the likelihood of side effects, suggesting a safer adjunct to opioid therapy.
Daily Cannabis Use Associated With Higher Rates of Opioid Cessation Among People With Chronic Pain
Published in Substance Use & Misuse, this study found that individuals with chronic pain who used cannabis daily were significantly more likely to stop using opioids compared to non-cannabis users. The analysis of nearly 9,000 participants suggested that daily cannabis use may support opioid tapering in pain management strategies.
CBD, THC and the Terpene Humulene Show Synergistic Anticancer Effects in Breast Cancer Models
Published in Cannabis and Cannabinoid Research, this study found that the combination of CBD, THC, and the terpene humulene exhibited strong synergistic effects against breast cancer cells. The triple combination significantly reduced cancer cell viability and migration more effectively than any compound alone, suggesting enhanced therapeutic potential.
CBD and CBG Show Potential in Combating HER2-Positive Ovarian Cancer
Published in Cells, this study demonstrated that cannabidiol (CBD) and cannabigerol (CBG) inhibited the growth of HER2-positive ovarian cancer cells. The cannabinoids disrupted mitochondrial function, reduced cancer cell proliferation, and altered key signaling pathways, pointing to their promise as targeted treatments for aggressive ovarian tumors.
Combination of CBD and THC May Reduce Migraine Symptoms
Published in Phytotherapy Research, this study found that a 1:1 ratio of cannabidiol (CBD) and tetrahydrocannabinol (THC) reduced the frequency and intensity of migraine attacks in patients with chronic migraines. The treatment also improved quality of life and sleep, with minimal side effects reported.
CBD-Coated Pillow Cover May Serve as an Effective Aid in Improving Sleep Quality
Published in Frontiers in Psychiatry, this randomized controlled trial found that individuals using a pillow cover coated with microencapsulated CBD experienced improvements in sleep duration and quality. The benefits were more pronounced among participants with sleep difficulties, suggesting a non-invasive method for CBD delivery.
Cannabigerol Inhibits Growth of Drug-Resistant Streptococcus iniae by Disrupting Cell Membranes
Published in Microorganisms, this study showed that cannabigerol (CBG) effectively killed drug-resistant Streptococcus iniae by damaging its cell membranes. The findings suggest CBG may serve as a novel antimicrobial agent against pathogens that threaten both aquaculture and human health.
CBD Significantly Reduces Pain and Inflammation in Patients With Temporomandibular Disorder
Published in Frontiers in Pain Research, this randomized controlled trial found that topical CBD gel significantly reduced pain intensity and improved jaw function in patients with temporomandibular disorder (TMD). The treatment also decreased local inflammation and was well tolerated, with no serious adverse effects reported.
CBD-Rich Cannabis Extract Outperforms Hydrocortisone in Reducing Skin Inflammation
Published in Toxics, this study found that a CBD-rich cannabis extract reduced markers of skin inflammation more effectively than hydrocortisone in a mouse model. The extract decreased levels of pro-inflammatory cytokines and showed antioxidant properties, suggesting it could be a safer and more effective alternative for inflammatory skin conditions.
CBD Shown to Prevent Tooth Decay in Laboratory Model
Published in ACS Omega, this study found that cannabidiol (CBD) inhibited the growth of Streptococcus mutans, a primary bacterium responsible for tooth decay. In laboratory models, CBD reduced acid production, biofilm formation, and bacterial viability, indicating potential as a novel compound in oral hygiene products.
CBD Effective in Reducing Itching and Improving Quality of Life for Atopic Dermatitis Patients
Published in Dermatologic Therapy, this clinical study found that topical cannabidiol (CBD) significantly reduced itching severity and improved sleep, mood, and overall quality of life in patients with atopic dermatitis. The treatment was well tolerated, with no adverse effects reported during the 4-week study period.
CBD Reduces Nerve Pain and Improves Memory by Activating Pain and Mood Receptors
Published in Phytotherapy Research, this study found that cannabidiol (CBD) reduced neuropathic pain and improved memory in mice by activating serotonin 5-HT1A and cannabinoid CB1 receptors. The results suggest CBD may offer dual benefits for managing chronic pain and cognitive dysfunction.
Medical Cannabis Improves Outcomes for Patients With Hypermobility-Associated Chronic Pain
Published in Pain Reports, this study found that medical cannabis use led to significant improvements in pain, sleep, anxiety, and physical functioning in patients with hypermobility spectrum disorders and hypermobile Ehlers-Danlos syndrome. Most patients reported better quality of life and reduced reliance on conventional medications.
CBD May Counteract Negative Effects of High-Calorie Diet, Improve Insulin Regulation
Published in Antioxidants, this study found that cannabidiol (CBD) improved insulin sensitivity, glucose metabolism, and pancreatic islet structure in mice fed a high-calorie diet. CBD reduced inflammation and oxidative stress, suggesting it may help counteract metabolic disorders caused by poor diet.
CBD May Protect Against Epilepsy-Related Neuronal Death by Blocking Toxic Astrocytes
Published in Frontiers in Cellular Neuroscience, this study found that CBD reduced neuronal damage in a rat model of epilepsy by preventing astrocytes from transitioning into a neurotoxic state. The results suggest a new mechanism through which CBD may offer neuroprotection in epilepsy.
Mouthwash With CBD and Spilanthol Significantly Improves Oral Health Markers in Gingivitis Patients
Published in the International Journal of Environmental Research and Public Health, this clinical trial found that a mouthwash containing CBD and spilanthol significantly reduced gum bleeding, plaque, and inflammation in patients with gingivitis after 4 weeks of use. The treatment was safe and well tolerated.
Cannabis Terpenes Effectively Treat Fibromyalgia and Post-Surgical Pain
Published in Advances in Therapy, this clinical trial found that a blend of cannabis-derived terpenes significantly reduced pain scores in patients with fibromyalgia and post-surgical pain. The terpene formulation was effective on its own and when used alongside opioids, offering a promising non-opioid pain management option.
