420 Peer-Reviewed Cannabis Studies, All Published in 2025

By Anthony Martinelli
November 17, 2025
152 mins to read

Scientific interest in cannabis has accelerated at an unprecedented pace, with 2025 producing more peer-reviewed research than any year on record.

Across oncology, neurology, psychiatry, pain, metabolism, immunology, addiction, agriculture and more, researchers published over 420 new studies examining the plant’s therapeutic potential, safety profile, cultivation techniques, and real-world impacts of both the plant and policies surrounding it.

With that in mind, below is a comprehensive, study-by-study breakdown of every one of those findings, offering a clear snapshot of what modern cannabis science reveals.

Clinical Trial Finds THC Significantly Reduces Alcohol Consumption in Heavy Drinkers

In a randomized trial of heavy drinkers, administration of THC led to a marked reduction in alcohol intake and craving compared with placebo, suggesting THC might serve as a potential harm-reduction tool for alcohol use disorder.

Study: Cannabis Use Linked to Lower Rates of Chronic Rhinosinusitis and Fewer Sinus Surgeries in New Study

A large retrospective analysis found that regular cannabis users had significantly reduced incidence of chronic rhinosinusitis and required fewer sinus surgeries compared with non-users, hinting at a potential protective or anti-inflammatory effect of cannabis on sinonasal health.

Study: CBD Shows Antispasmodic and Antidiarrheal Benefits in New Gastrointestinal Study

Researchers reported that CBD reduced intestinal spasms and normalized bowel motility in preclinical models, also decreasing frequency and severity of diarrhea — pointing toward therapeutic promise for conditions like IBS or other GI disorders.

Study: CBD-Rich Marijuana Eases Anxiety and Repetitive Behaviors in Autistic Children, Finds Study

In an observational cohort of autistic children, use of CBD-dominant cannabis was associated with reductions in anxiety, irritability, and repetitive behaviors, along with improvements in social responsiveness; parents reported these changes within weeks of use.

Study Finds CBD Shields Primary Neurons From Rotenone-Induced Toxicity Through TRPV1 Pathways

In neuronal cell cultures exposed to rotenone (a Parkinson’s-linked neurotoxin), CBD treatment preserved neuron viability by activating TRPV1 receptor pathways, reducing oxidative stress and limiting mitochondrial dysfunction — indicating neuroprotective potential against environmental toxins.

Clinical Trial: CBD Shown to Reduce Behavioral Symptoms in Older Adults With Vascular Dementia

In a randomized clinical trial, older adults with vascular dementia receiving CBD experienced reductions in agitation, anxiety, and aggression, along with modest improvements in mood and caregiver-reported quality of life—suggesting CBD may help manage neuropsychiatric symptoms in dementia.

Study: CBD Found to Reduce Emotional, Molecular and Alcohol-Seeking Effects of Prenatal Alcohol Exposure

In animal models exposed prenatally to alcohol, CBD treatment later in life reduced anxiety-like behaviors, normalized stress-related brain molecular markers, and lowered propensity for alcohol seeking—pointing to therapeutic potential in mitigating developmental alcohol exposure effects.

Study: CBD Shown to Prevent Key Scarring Processes on the Eye’s Surface, Study Finds

Laboratory research demonstrated that topical CBD application suppressed fibroblast activation and collagen deposition on ocular surface tissues—processes linked to scarring and impaired vision—suggesting a possible role for CBD in preventing postoperative or injury-induced eye fibrosis.

Study Finds Google Maps To Be the Most Accurate Tool for Identifying U.S. Marijuana Dispensaries

A validation study comparing multiple public databases of cannabis retailers concluded that Google Maps listings had the highest accuracy and coverage for locating licensed marijuana dispensaries across the United States—useful insight for researchers and consumers tracking dispensary availability.

Study: CBD Boosts the Effectiveness of Phenobarbital in Newborn Seizure Model, Study Finds

In neonatal animal models, adding CBD to phenobarbital therapy enhanced seizure suppression more than phenobarbital alone — suggesting CBD could improve outcomes in newborn seizure disorders when used as an adjunct.

Study: Liposomal CBD Injections Show Weeks-Long Pain Relief and Steady CBD Levels in Goats

Researchers found that a single liposomal-CBD injection provided prolonged analgesia lasting several weeks and maintained stable blood CBD concentrations in a goat model, offering a proof-of-concept for long-acting cannabinoid formulations.

Study: CBD Shows Antimicrobial Potential Against Oral Pathogens, Study Finds

Laboratory assays demonstrated that CBD inhibited growth of several common oral bacterial pathogens and reduced biofilm formation, indicating possible uses in dental hygiene products or treatments for oral infections.

Study: 3D-Printed CBD Oral Delivery

Scientists developed a novel 3D-printed oral tablet embedded with CBD that allowed controlled release and improved dosing precision, marking a step forward for customizable cannabinoid pharmaceuticals.

CBD-Rich Cannabis Extract Shows Strong Immunomodulatory Effects in T-Cell Study

In a lab study analyzing human T-cells, a CBD-rich cannabis extract significantly modulated cytokine production and shifted T-cell differentiation toward a more regulatory phenotype, indicating potential for autoimmune and inflammatory-disease treatment.

Study: Cannabidiol Suppresses Tumor Growth in Colon Cancer by Targeting Metabolic Pathways

Preclinical models of colon-cancer showed that CBD inhibited tumour growth and altered cancer-cell metabolism—specifically reducing glycolysis and lipid synthesis—pointing to novel metabolic targets for cannabinoid therapy in oncology.

Cannabis Extract Shows Strong Lethal and Repellent Effects Against Chagas Disease Vector

Researchers found that certain cannabis-derived extracts were highly toxic to triatomine bugs (the vector for Chagas disease) and also acted as strong repellents, opening new possibilities for vector-control interventions in tropical disease management.

CBD May Reduce Some Cellular Harms from Doxycycline Exposure, Study Finds

In cell culture models, CBD reduced indicators of mitochondrial stress and DNA damage that were induced by doxycycline treatment, suggesting a potential protective co-therapy role when using certain antibiotics.

Autistic Adults Report 73 % Short-Term Symptom Relief After Using Inhaled Cannabis

Survey data from adults with autism spectrum disorder revealed that 73 % reported immediate relief in anxiety, irritability, or sensory overload symptoms after inhaled cannabis, with improvements lasting several hours; long-term outcomes remain untested.

Cannabinoids Like CBGA, CBN and CBG May Reduce HIV-Related Pain

Leveraging human cohort data and experimental models, scientists observed that CBGA, CBN, and CBG were associated with reduced incidence of neuropathic pain among people living with HIV, supporting minor-cannabinoid research in pain management.

Hemp Flour Significantly Boosts Bread’s Nutrition With Only Minor Effects on Flavor

Researchers at the University of Parma found that incorporating 10 % to 25 % hemp flour into wheat bread increased protein content, introduced omega-3 linolenic acid, enhanced essential amino acids and raised antioxidant capacity; sensory panel ratings remained favorable up to 15 % hemp substitution.

Cannabis Leaf Diet Helps Protect Farmed Fish From Parasitic Liver Flukes, Study Finds

In aquaculture research, tilapia fed a diet supplemented with cannabis leaves showed significantly lower incidence of liver fluke infection and improved liver health, suggesting a novel plant-based strategy for fish farm disease management.

IGC-AD1 Targets Agitation in Alzheimer’s With a Cannabis-Based Investigational Therapy

A phase 2 clinical trial of IGC-AD1, a cannabis-derived compound, demonstrated reduction in agitation and aggression in patients with Alzheimer’s disease, offering hope for non-standard medications in symptom management.

Balanced THC/CBD Formula Protects Developing Brain Cells From Hypoxia-Related Damage

In vitro models of neonatal brain ischemia showed that a 1:1 THC:CBD formulation preserved neuronal viability and reduced oxidative stress after hypoxic insult, suggesting potential neuroprotection in perinatal brain injury scenarios.

CBD and CBDV Combination Reduces IBD-Related Gut Inflammation by Targeting Key Immune Receptor

Experimental models of inflammatory bowel disease (IBD) found that combined cannabidiol (CBD) and cannabidivarin (CBDV) markedly reduced gut inflammation via modulation of the P2X7 receptor and subsequent immune signalling pathways, pointing to a novel therapeutic direction.

Cannabis Use Linked to Reduced Risk of Oral Cancer, New Meta-Analysis Finds

A comprehensive meta-analysis of epidemiological studies revealed a statistically significant association between cannabis use and a lower incidence of oral cavity and pharyngeal cancers, though authors caution about confounding factors and call for prospective research.

THC Strengthens Brain-Based Pain-Filtering in Fibromyalgia, New Clinical Trial Finds

In a randomized trial, patients with fibromyalgia using a THC-dominant cannabis formulation showed enhanced functional MRI responses in brain regions associated with endogenous pain inhibition, accompanied by reductions in pain intensity and improved quality of life.

Hemp Shows Strong Antiviral Activity Against Japanese Encephalitis Virus

Laboratory tests revealed that hemp seed extracts inhibited replication of the Japanese encephalitis virus in neuronal cell models, suggesting antiviral properties beyond cannabinoids and pointing to new bioactive targets in hemp.

Higher Light Intensity During Flowering Found to Boost CBD Production in Hemp

An agronomic study on hemp cultivation demonstrated that increasing light intensity during the flowering phase led to higher CBD concentrations in harvested biomass, indicating lighting strategy is a significant factor in cannabinoid yield optimization.

Study: Medical-Grade THC Vape Delivers Precise Microdoses While Retail Pens Hit Hard But With Unstable Output

Comparing medical-grade and retail THC vape devices, investigators found that the medical product provided consistent microdoses and predictable pharmacokinetics, whereas retail pens showed greater variability in dosing and higher peak exposures, highlighting concerns over consumer device reliability.

Study: CBD Shown to Suppress Growth Pathways in Aggressive Breast Cancer Cells

In vitro research revealed that cannabidiol (CBD) downregulated key oncogenic signalling pathways in triple-negative breast cancer cells, including PI3K/AKT and MAPK pathways, leading to reduced proliferation and increased apoptosis.

VA and University of Iowa Study Finds High-CBD, Low-THC Formula Can Reduce Migraine-Like Symptoms

A clinical trial involving veterans found that a high-CBD, low-THC cannabis formulation significantly reduced migraine frequency and intensity compared to placebo, with minimal side-effects reported.

Nanoemulsion Greatly Improves CBD Absorption and Anti-Inflammatory Effects

Researchers developed a nanoemulsified CBD formulation that showed substantially higher bioavailability and stronger suppression of inflammatory markers in a rodent model compared with standard formulations.

Cannabis Extracts with THC, CBD and CBN Reduce Parkinson’s-Related Protein Toxicity in Cell Models

In cell-culture models of Parkinson’s disease, combined extracts containing THC, CBD and CBN reduced aggregation of α-synuclein and mitigated mitochondrial dysfunction, indicating potential for multi-cannabinoid therapies in neurodegenerative disorders.

Cannabinoids May Help Manage Diabetes by Lowering Blood Sugar, Improving Cholesterol and Protecting Organs

Preclinical data suggest cannabinoids improved glucose homeostasis, raised HDL cholesterol, lowered LDL and triglycerides, and protected kidney and liver tissues in diabetic models—supporting further investigation into metabolic-disease applications.

CBD Shows Broad Effectiveness in Treating Severe Epilepsies

A multicenter retrospective cohort found that cannabidiol (CBD) produced meaningful seizure-reductions in a range of developmental and epileptic encephalopathies (DEEs), especially in genetic cases like Tuberous Sclerosis Complex and Lennox-Gastaut Syndrome. Patients also reported benefits beyond seizures—including improved alertness (56 %), sleep quality (25 %), and motor function (14 %). About one-third experienced adverse effects (mostly mild), and 9 % discontinued because of side-effects.

Medical Marijuana, Especially CBD-Rich Enteral Products, Reduces Anxiety and Depression in Cancer Patients

In a large patient registry, cancer patients using medical cannabis — particularly CBD-dominant oral products — reported significant reductions in anxiety and depressive symptoms. The anxiety relief correlated most strongly with higher CBD doses rather than higher THC content, suggesting formulation matters.

Inhaled Cannabis for Diabetic Neuropathy Patients

In a controlled trial of patients with painful diabetic peripheral neuropathy, inhaled cannabis significantly reduced pain intensity and improved sleep compared to placebo, demonstrating inhalation as a viable administration route for neuropathic pain relief.

Study: Cannabis Use Not Linked to Increased Blood-Clot Risk in Trauma Patients

In trauma-ward data analysis, patients with documented cannabis use did not show higher incidence of deep vein thrombosis or pulmonary embolism compared with non-users—providing preliminary reassurance about clot-risk in acute care settings.

Cannabis Extract for Alzheimer’s / Dementia

In patients with mild-to-moderate Alzheimer’s disease or related dementias, a standardized cannabis extract improved cognitive scores and reduced markers of neuroinflammation over six months, suggesting potential disease-modifying effects.

Thyme Essential Oil and Cannabinoids Show Synergistic Benefits for Inflammatory Skin Conditions

Laboratory and early-phase clinical work found that combining cannabinoids (CBD/THC) with thyme essential oil produced stronger anti-inflammatory and anti-pruritic effects in dermatologic models than either alone—pointing to botanical synergy in topical formulations.

Cannabidivarin (CBDV) Shows Anti-Cancer Potential

New research indicates that the minor cannabinoid cannabidivarin (CBDV) directly targets immunosuppressive myeloid cells in the tumor microenvironment, restores CD8+ T-cell function and slows tumor progression in vivo.

Study: Cannabis Use Linked to Longer Sleep—but Effects Vanish With Alcohol

Large-scale survey data show cannabis users report longer sleep duration and improved sleep quality compared to non-users—but these benefits disappear when combined with alcohol, underlining the interaction between substances.

Medical Marijuana Use in Louisiana Linked to Reduced Reliance on Prescription Painkillers, Study Finds

Analysis of state-level claims data in Louisiana revealed that patients enrolled in the medical-cannabis program were significantly less likely to fill opioid and other pain-medication prescriptions, suggesting substitution effects.

Marijuana Stores Oregon & Alcohol

In Oregon, adults living near more licensed cannabis retail stores had higher odds of frequent cannabis use and lower odds of heavy alcohol consumption, pointing to an association between greater cannabis access and reduced alcohol use.

Cannabis Use on the Rise as Cigarette Smoking Continues to Decline, Finds Study

National trends indicate rising rates of cannabis use even as cigarette smoking and traditional tobacco use continue to fall, suggesting shifting patterns of substance consumption across demographics.

CBD Shown to Prevent Opioid-Induced Respiratory Depression, Finds Study

In animal models, high-dose CBD pretreatment significantly delayed the onset of opioid-induced apnea and raised the lethal dose threshold of fentanyl to levels comparable to the opioid antagonist naloxone, suggesting CBD may offer a novel adjunctive approach to counter respiratory depression from opioids.

CBD Counters Methamphetamine Addiction by Targeting Key Brain Energy Protein

Researchers found that CBD modulated the brain’s AMPK-related energy signalling pathways in a methamphetamine addiction model, reducing drug-seeking behaviour and supporting further investigation of CBD as a treatment for stimulant use disorders.

Cannabis-Derived Nanocomposite Shows Potent Antioxidant Properties

A novel nanocomposite material incorporating cannabis-derived components demonstrated strong antioxidant activity in in vitro models, opening possibilities for wound care, biomaterials, and oxidative-stress mitigation applications.

Cannabinoids, Especially CBD with THC, Offer Effective Relief for Migraines, Study Finds

Clinical data indicate that formulations combining CBD and THC reduced both the frequency and severity of migraine attacks more than standard therapies, with improved patient-reported quality of life and fewer side-effects.

Marijuana/Opioid Surgery

Perioperative data suggest patients using cannabis prior to surgery required fewer postoperative opioids and reported lower pain scores, hinting at cannabis-related modulation of postoperative pain and opioid needs in surgical care.

Cannabinoids Show Potential to Improve Survival and Reduce Organ Damage in Sepsis

Preclinical models of sepsis treated with cannabinoids showed improved survival rates, reduced organ injury, and modulation of inflammatory pathways, suggesting a potential role for cannabinoids as adjunctive therapies in critical care settings.

Study Finds CBD Can Improve Sleep in Cancer Patients, Especially at Higher Doses

In a cancer patient cohort, higher doses of CBD correlated with significant improvements in sleep quality and reductions in sleep latency, highlighting CBD’s potential benefit for insomnia in oncology settings.

Cannabis Use Linked to Significantly Lower Risk of Alcohol-Associated Liver Disease

A large retrospective analysis found that regular cannabis users had a markedly lower incidence of alcohol-related liver disease and cirrhosis, hinting at protective effects worth further investigation.

Cannabis-Based Medicine for Tourette Syndrome

Emerging clinical data suggest that cannabis-based treatments may reduce tic severity and improve quality of life for patients with Tourette Syndrome, supporting the advancement of cannabinoid therapy in neuropsychiatric conditions.

Synergistic Effects of CBD and Beta-Caryophyllene May Help Treat Pain and Depression

Preclinical studies show that combining CBD with the terpene beta-caryophyllene provides greater analgesic and antidepressant effects than either alone, supporting the concept of “entourage effect” in cannabinoid-terpene pairings.

New CBD Microemulsion Delivery System Improves Stability

Researchers developed a novel microemulsion formulation of CBD that significantly improved its chemical stability, shelf life, and bioavailability, suggesting enhanced therapeutic potential for CBD-based products.

Study: CBD Reduces Pain and Itching in Children With Recessive Dystrophic Epidermolysis Bullosa

In a compassionate-use setting, children with recessive dystrophic epidermolysis bullosa treated with CBD reported reductions in pain and pruritus, with improved sleep and fewer dressing changes, pointing to novel supportive care applications.

Controlled Trial: CBD/CBDA Paste Reduces Osteoarthritis Pain in Cats

A randomized, placebo-controlled trial in felines with osteoarthritis found that a paste containing both CBD and CBDA improved mobility scores, reduced pain-related behaviors and was well tolerated; potential implications extend to companion-animal and human OA therapy.

Study: CBD Shows Potential for Treating Cardiovascular Disease

Preclinical cardiology research revealed that CBD improved endothelial function, reduced myocardial inflammation and attenuated hypertrophy in disease models—suggesting it may offer a complementary approach to cardiovascular treatment.

Study: Wastewater Analysis Finds Cannabis Use Rising in Japan With CBD Use Far More Prevalent

Municipal wastewater surveillance in Japan detected increases in cannabis biomarkers, particularly CBD metabolites, indicating shifting consumption patterns and possible growth in non-psychoactive cannabis product use.

Study: Mitochondrial Cannabinoid Receptors Play Key Role in Skeletal Muscle Health and Function

Research identified mitochondrial CB1/CB2 receptors in skeletal muscle cells as regulators of mitochondrial biogenesis and muscle performance; modulation by cannabinoids suggests a new avenue for muscle health interventions.

Study: Cannabis Extract Shows Pain-Relieving, Anti-Inflammatory and Anti-Dysmenorrheal Effects

Women experiencing primary dysmenorrhea treated with a standardized cannabis extract reported reduced pain severity, less inflammation and improved daily function, pointing to cannabis’ potential in menstrual health management.

Study: Cannabis Use Linked to Reduced Fatigue and Cognitive Symptoms in MS and Parkinson’s Patients, Finds Study

In patients with Multiple Sclerosis and Parkinson’s Disease, self-reported cannabis use was associated with lower fatigue scores, less emotional variability, and better cognitive performance, suggesting a beneficial effect on non-motor symptoms in these populations.

Study: Novel Electrochemical Sensor Offers Rapid Selective Detection of CBD and THC

Researchers developed a molecular-imprinted platinum-iridium‐alloy electrode capable of distinguishing Cannabidiol (CBD) from Tetrahydrocannabinol (THC) using oxidation potentials, achieving detection limits of ~1.2 µM for CBD and ~1.7 µM for THC, demonstrating a promising tool for rapid quality control in cannabis products.

Study: Age, Sex and Carrier Oil All Influence How Vaping Marijuana Affects the Body, Study Shows

In a human trial examining vaping cannabis, researchers found that pharmacokinetic and effect profiles varied significantly by participant age, biological sex, and the type of carrier oil used in the vaping formulation—highlighting the need for personalized dosing and formulation considerations.

Study: Recreational Marijuana Legalization Linked to Fewer Opioid Overdose Deaths

An epidemiological study observed jurisdictions that legalized recreational cannabis had a statistically significant reduction in opioid overdose death rates over subsequent years compared to those that did not, suggesting a possible public-health benefit linked to cannabis policy.

Study: Cannabidiol Alters Gene Expression Linked to Immune Response and Cell Death in Leukemia Cells

In vitro work on leukemia cell lines showed that CBD modulated expression of genes associated with apoptosis, immune regulation, and cell-cycle control, indicating potential synergy with conventional therapies for hematologic malignancies.

Study Finds Blunt Smoking Rising Sharply Among U.S. Adults, Especially Women and Non-Drinkers

National survey data indicate a significant increase in blunt (cannabis rolled in tobacco leaf) use among U.S. adults over recent years, with the largest upticks seen among women and individuals who do not drink alcohol, raising implications for dual-use public health messaging.

Study: Irrigation Levels Influence Hemp Biomass but Not Cannabinoid Concentrations

Agronomic research on industrial hemp found that while different irrigation volumes affected overall plant biomass significantly, they did not substantially alter concentrations of key cannabinoids like CBD or THC, suggesting some flexibility in water use without compromising cannabinoid content.

CBD-Wound Healing

A preclinical assessment of cannabidiol (CBD) in wound-healing models demonstrated accelerated closure rates, reduced scarring and improved dermal regeneration compared with controls, supporting further exploration of CBD-infused dressings or topical therapies.

Study: Finds Cannabis Use Associated With Lower Odds of Common Sinonasal Diseases

Epidemiological data show that regular cannabis users had lower prevalence of chronic rhinosinusitis and related disorders compared with nonusers, though causality remains undetermined and further investigation into mechanisms is called for.

Study: Public Support for Medical Cannabis in Poland Is Above 80 % but Clinical Integration Still Lags

A national survey found over 80 % of Polish citizens support medical-cannabis access, but actual clinical implementation—including training, prescribing frameworks and reimbursement—is still significantly behind public sentiment.

Study: Industrial Hemp Supplementation Reduces Stress and Improves Antioxidant Levels in Angus Cattle

In a 35-day trial, Angus heifers fed industrial hemp showed reduced cortisol levels, higher antioxidant activity (including glutathione peroxidase), and decreased markers of oxidative stress—while digestive health remained stable.

Study: Cannabigerol May Protect Colon Health and Improve Metabolic Function Under High-Fat, High-Sugar Diet

Rats on a high-fat, high-sugar diet received cannabigerol (CBG) and showed reduced ceramide levels in the colon, improved insulin signalling and lower inflammatory cell infiltration—indicating CBG may counter diet-induced metabolic and colon damage.

Study: CBD Reduces Neuroinflammation in Alzheimer’s Model by Targeting Key Immune Pathways

In Alzheimer’s disease animal models, CBD treatment lowered immune-mediated neuroinflammation and improved cognitive read-outs, suggesting modulation of microglial and cytokine signalling as part of its mechanism.

Study: Hemp Seed Extract Reduces Obesity Markers Through AMPK Pathway

Preclinical work found that hemp-seed extract activated the AMPK signalling pathway in obese models, resulting in lower body-fat markers and improved metabolic profiles, positioning hemp seed derivatives as potential anti-obesity agents.

Study: CBD Suppresses HIV and SIV Replication and Slows Immune Decline in Preclinical Models

In lab and animal models of HIV/SIV, CBD was shown to suppress viral replication, preserve CD4+ cell counts and slow immune deterioration, offering a compelling preclinical case for adjunctive therapy in viral-immune disorders.

Clinical Trial Finds Marijuana Extract Safer and More Effective than Opioids for Chronic Low Back Pain

A phase 3 trial with 384 participants compared a full-spectrum cannabis extract (VER-01) against opioids for chronic low back pain over six months. The cannabis group had stronger pain relief, fewer bowel complications, and no withdrawal or dependence, offering a potential non-addictive alternative.

Study: THC in Cannabis Resin Nearly Disappears After Two Years of Storage, While CBN and CBD Increase

Long-term storage analysis found that THC levels in resin degrade sharply over two years, while CBN and CBD concentrations increase, underscoring the importance of storage conditions for cannabinoid stability and potency.

Study Finds Major Inaccuracies in THC Labeling of Cannabis Edibles in Mississippi

Testing of edible cannabis products revealed large discrepancies between labeled THC content and actual amounts, raising concerns about consumer safety, dosing reliability, and regulatory oversight in the marketplace.

Study: Cannabis Use Common Among Medical Students Worldwide, With Rising Trends in Recent Years

A global survey of medical students found increasing cannabis use over recent years, exploring associations with stress, sleep, and academic performance, and prompting calls for education on use versus misuse.

Study Finds CBD Reduces Anxiety and Inflammation Caused by Obesity and Aging

Experimental work showed that CBD alleviated anxiety-like behavior and decreased inflammatory markers in older obese models, suggesting therapeutic potential for age- and weight-related neuro-inflammation and mood disruptions.

Study: CBD-Loaded Microparticles Show Potential for Colorectal Cancer Treatment

Researchers developed microparticle-based delivery systems for CBD that increased tumor targeting and efficacy in colorectal cancer models, suggesting enhanced formulation strategies could improve clinical outcomes.

Study: Finds Blue-Red LED Ratios Drive Higher CBD Yield in Cannabis

A controlled cultivation study revealed that optimizing blue-to-red LED light ratios significantly increased CBD content in Cannabis sativa plants, offering growers a scalable method to improve cannabinoid yield and consistency.

Researchers Discover New Cannabinoid Cannabizetol With Remarkable Antioxidant and Skin Anti-Inflammatory Activity

A novel cannabinoid named cannabizetol was isolated and found to have strong antioxidant and anti-inflammatory effects on skin cells, opening potential applications in dermatological and cosmetic therapy.

THCV Study Finds Favorable Safety Profile, Mild THC-Like Effects at Higher Doses

A first-in-human trial of THCV demonstrated that moderate to high doses are well tolerated, with mild euphoria at higher levels and no serious adverse events, supporting further exploration of THCV’s therapeutic role.

Study: Hybrid CBD and Silver Hydrogel Shows Strong Antimicrobial Potential for Wound Care

A hybrid hydrogel combining CBD and silver nanoparticles exhibited potent antimicrobial and wound-healing activity in preclinical models, suggesting an innovative path for cannabis-derived materials in medical device and wound-care settings.

Study: CBD Reduces Heroin-Seeking Behavior by Altering Key Brain Pathways

Animal research showed CBD reduced cue-induced heroin-seeking while normalizing gene-expression changes in the nucleus accumbens, especially those tied to immune signaling, astrocyte activity, and extracellular matrix regulation.

Cannabis and Autism: Six Recent Studies Highlight CBD’s Potential Role in Reducing Symptoms and Protecting Brain Function

A review of six studies found CBD improved core and co-occurring symptoms in autism, including anxiety, irritability, and repetitive behaviors, with preclinical data suggesting additional neuroprotective effects.

Study: CBD Alzheimer’s Study

CBD reduced neuroinflammation and improved memory-related outcomes in Alzheimer’s models, strengthening evidence that it may offer a low-cost, non-invasive therapeutic avenue for neurodegenerative disease.

Study: Cannabis Polysaccharides Show Antioxidant and Anti-Aging Potential

Cannabis-derived polysaccharides demonstrated strong antioxidant activity and reduced markers of cellular aging, suggesting they may contribute to cannabis’ broader therapeutic profile.

Study: CBD Leukemia

Preclinical results showed CBD inhibited leukemia cell growth and promoted apoptosis, indicating potential supportive use of cannabinoids in certain blood cancers.

Study: Subcritical Water Extraction Offers Sustainable Alternative for Cannabinoid Recovery

Researchers demonstrated that subcritical water extraction efficiently recovers cannabinoids with lower environmental impact than conventional methods, paving the way for greener production of cannabis-derived medicines.

Study: Chlorophyll Compounds Boost CBD Bioavailability and Therapeutic Effects

The addition of chlorophyll derivatives to CBD formulations was found to enhance absorption and amplify therapeutic outcomes, suggesting a novel formulation strategy for more effective CBD therapies.

Study: Cannabis Use Linked to Lower Stress and Improved Sleep for Veterans with PTSD

Among veterans diagnosed with PTSD, cannabis use was correlated with reductions in perceived stress and improvements in sleep quality, indicating a potential supportive role for cannabis in trauma-related care.

Study: CBD Nanoemulsion Shows Antitumor Potential in Canine Mammary Cancer Cells

A nanoemulsified CBD formulation significantly inhibited proliferation and induced apoptosis in canine mammary cancer cell lines, highlighting the promise of advanced delivery systems in veterinary oncology and comparative research.

Study: Finds CBD Enhances Effectiveness of FGFR Inhibitors in Colorectal Cancer Treatment

Preclinical models showed that adding CBD to FGFR-inhibitor therapy boosted antitumor activity in colorectal cancer, suggesting a synergistic effect and a possible avenue for adjunctive cancer treatment.

Study: Cannabis — Both High-CBD and High-THC — May Improve Metabolic Health in Obesity

In people with obesity, both high-CBD and high-THC cannabis products were associated with improved metabolic markers — including better glucose regulation and reduced waist circumference — suggesting potential adjunct therapies for metabolic health.

Study: Medical Cannabis Legalization Across 20 Countries Tied to Sustained Growth in Sales, Substitution With Tobacco

An international analysis found that in 20 countries where medical cannabis was legalized, cannabis-related product sales grew steadily over several years and consumption patterns shifted, with evidence of substitution away from tobacco use.

Study: Medicinal Cannabis Could Help Reduce Opioid Deaths and Address Global Health Inequities

A review found that medicinal cannabis may lower opioid-related deaths and improve health equity worldwide. Researchers argue expanding access could address disparities in pain management and provide safer alternatives to opioids.

Study: Cannabis-Derived Packaging Preserves Grapes Longer

Scientists developed cannabis-derived biodegradable packaging that significantly extended grape shelf life by reducing microbial growth and oxidation. The study points to sustainable applications of hemp-based materials in food preservation.

Study: Cannabis Use Not Independently Linked to Head and Neck Cancer, Unlike Alcohol and Cigarettes

A population-based analysis found no independent association between cannabis use and head or neck cancers, while alcohol and cigarette use remained strong risk factors. The results suggest cannabis does not carry the same cancer burden as these substances.

Study: Medicinal Cannabis Could Help Reduce Opioid Deaths and Address Global Health Inequities

Researchers concluded that medicinal cannabis may play a role in reducing opioid-related deaths and alleviating health inequities worldwide. The review emphasized cannabis’ therapeutic promise while calling for broader access and global policy reform.

Study: Higher Education Levels Linked to Increased Marijuana Use, Opposite of Cigarette Trends

Analysis showed that people with higher education levels are more likely to use marijuana, while cigarette use decreases with education. The findings highlight diverging social trends between marijuana and tobacco consumption.

Study: Encapsulated Cannabis Extracts Show Potent Antimicrobial Effects in Dermatology

Researchers demonstrated that encapsulated cannabis extracts had strong antimicrobial effects against bacteria and fungi in dermatological applications, suggesting potential use in treating skin infections and related conditions.

Study: CBD Reduces Seizures in 68% of Patients With Genetic Variants Influencing Response

A clinical study found that CBD treatment reduced seizures in 68% of patients with specific genetic variants affecting drug response. Results highlight the importance of personalized medicine in epilepsy care.

Study: Medical Cannabis Improves Quality of Life for Cancer Patients

Cancer patients using medical cannabis reported significant improvements in quality of life, including reduced pain, better sleep, and less anxiety. The study supports cannabis as a supportive care option in oncology.

Marijuana Trichomes Study

Researchers analyzed trichomes on cannabis plants and found that their density, size, and chemical makeup vary significantly by strain, cultivation method, and growth stage. The findings provide new insight into optimizing cannabinoid and terpene production.

Cannabis Linked to Pain Relief and Better Quality of Life in Complex Regional Pain Syndrome Patients

A study on patients with complex regional pain syndrome reported that medical cannabis use reduced pain levels and improved quality of life. Results suggest cannabis could serve as a valuable adjunct therapy for this challenging condition.

Study: THC Supplementation Improves Inflammation and Metabolic Health in HIV Model

In a preclinical HIV model, THC supplementation was found to lower inflammation and enhance metabolic health. The study highlights the potential of THC in managing chronic inflammation associated with HIV.

Study: No Evidence of Residual Cannabis Effects on Driving After 48 Hours of Abstinence

A controlled study found no impairment in driving-related performance 48 hours after cannabis use, reinforcing that residual THC in the body does not equate to functional impairment once sufficient time has passed.

Cannabinoids and Sleep: CBD’s Role in Restorative Rest

A review of recent studies found that CBD shows promise in improving sleep quality by reducing anxiety, easing pain, and helping regulate sleep cycles. Evidence suggests cannabinoids may support better restorative rest, though more trials are needed.

Combination of CBD and SNP a Promising Therapeutic Strategy for Combatting Schizophrenia Symptoms

Preclinical research suggests that combining CBD with the nitric oxide donor SNP could provide synergistic benefits for managing schizophrenia symptoms, potentially offering a new therapeutic pathway worth further exploration.

Cannabinoids Provide Pain and Itch Relief and Improve Overall Well-Being for Patients With Rare Skin Disorder, Study Finds

A clinical study on patients with epidermolysis bullosa found that cannabinoid-based treatments reduced chronic pain and itching while also improving overall quality of life, highlighting cannabinoids’ therapeutic potential for rare skin conditions.

CBD Shown to Protect Brain Health in Offspring of Obese Mothers, Study Finds

Animal research demonstrated that prenatal exposure to CBD protected offspring of obese mothers from brain inflammation and neurodevelopmental impairments, pointing to possible preventative benefits that warrant further human studies.

Cannabis Use Linked to Lower Inflammation Among People With HIV or Methamphetamine Disorder

Researchers found that cannabis use was associated with reduced inflammation in individuals with HIV or methamphetamine use disorder. The findings suggest potential benefits for immune health, though further controlled studies are needed.

Study: CBD May Help Lower Systolic Blood Pressure

A clinical trial indicated that CBD supplementation may reduce systolic blood pressure in adults, pointing to its possible role in cardiovascular health management. Researchers note the need for larger, longer-term trials.

Study Finds Heavy Drinking Increases Risk of Unintended Pregnancy, Heavy Cannabis Use Does Not

An analysis showed that heavy alcohol consumption was linked to higher rates of unintended pregnancy, while heavy cannabis use was not significantly associated. The study underscores alcohol’s stronger role in reproductive health risks.

Study: Cannabinoid Medicines Positively Alter Key Inflammatory Markers in People With HIV

Clinical findings revealed that cannabinoid-based medicines improved several inflammatory markers in people living with HIV, suggesting potential therapeutic benefits in immune regulation and long-term health outcomes.

CBD Shows Unique Survival Benefit in Pancreatic Cancer Model, States Study

In a PDAC mouse model, CBD monotherapy extended survival while THC alone or the combo did not; benefits were linked to shifts in gut microbiota and bile acid metabolism, pointing to potential biomarkers and a therapeutic angle.

Harvard Study: CBD Reduces Anxiety Symptoms in Pilot Clinical Trial

An open-label, six-week pilot (n=12) using 30 mg/day full-spectrum sublingual CBD reported notable anxiety reduction with improvements in sleep and quality of life, no serious adverse events, and a call for larger placebo-controlled trials.

Study Explores Cannabis Compounds as Potential Tools Against COVID-19

Review of cannabinoids, terpenes, and other Cannabis sativa constituents suggests possible roles in blocking viral entry and tempering cytokine-driven inflammation (e.g., via CB2/PPARγ), while emphasizing the need for rigorous clinical validation and better bioavailability.

Study: THC and CBD Reduce Chemotherapy-Induced Nerve Pain, Improve Daily Function

Patient-reported outcomes (n=751) over six months showed clinically meaningful improvements in CIPN symptoms; THC-dominant regimens particularly helped burning/cold sensations, and THC/CBD interaction correlated with greater quality-of-life gains.

CBD May Improve Memory and Reduce Inflammation in Alzheimer’s Patients

A study from the University of Haifa found that in Alzheimer’s-model rats, chronic CBD reversed memory decline and reduced inflammation and Alzheimer’s-related brain pathology (amyloid plaques, tau) largely via CB1 receptor activation.

Cannabis May Reduce Alcohol Cravings and Consumption, Study Finds

In a controlled lab experiment involving people who regularly use both alcohol and cannabis, using cannabis before drinking reduced the number of alcoholic drinks consumed and lowered cravings in a subset of participants (“substituters”).

Medical Marijuana Improves Sleep and Anxiety in Insomnia Patients

Patients with insomnia who used medical marijuana reported better sleep quality and reduced anxiety symptoms over the study period.

CBD May Boost Effectiveness of EGFR Inhibitors in Treating Oral Cancer

In cell-based experiments, CBD enhanced the anti-cancer effects of EGFR inhibitors in oral cancer lines by suppressing resistance mechanisms and promoting cancer cell death.

Cannabinoids Show Potent Anti-Biofilm Activity Against MRSA

Researchers discovered that several cannabinoids—including CBD and CBG—disrupted MRSA biofilms and significantly reduced bacterial viability, even against stubborn, drug-resistant strains. The cannabinoids also suppressed expression of key resistance genes, pointing to their potential as novel anti-biofilm therapies.

New Universal Genetic Marker Identified for Early Cannabis Sexing

Scientists have developed a reliable DNA marker applicable across diverse cannabis varieties, enabling sex determination in seedlings. This breakthrough offers a practical, accurate alternative to labor-intensive early flowering methods and promises major efficiencies for growers.

One in 12 U.S. Cancer Survivors Use Marijuana—Nearly Half for Medical Purposes

A national survey revealed that approximately 8% of cancer survivors currently use marijuana, with almost half doing so specifically for symptom relief—including pain, nausea, anxiety, and sleep—with many noting improvements.

No Significant Change in Car Accidents Following Cannabis Legalization in Connecticut

Analysis of crash data before and after marijuana legalization in Connecticut showed no meaningful increase in traffic accidents or fatal crashes, suggesting that legalization did not adversely impact road safety in that context.

CBDA Shows Far Greater Bioavailability Than CBD in Animal and Cell Models

In comparative pharmacokinetic studies, CBDA—cannabidiolic acid—demonstrated markedly higher absorption and stability than CBD across both animal models and cell cultures, positioning it as a potentially more efficient therapeutic cannabinoid.

THC-Rich Hydrogels Developed for Safe, Sustained Topical Delivery

Researchers developed polyvinyl alcohol (PVA) hydrogels infused with THC and either propylene glycol or vegetable glycerin to enhance skin delivery. These hydrogels maintained structural stability, supported skin cell growth, and released THC gradually over several days, offering a safe, controlled-release system potentially useful for treating localized inflammation.

Nanoparticle Delivery of CBD Shows Strong Tumor Inhibition in Triple-Negative Breast Cancer

Scientists developed folic acid–modified chitosan nanoparticles carrying CBD, which outperformed free CBD against triple-negative breast cancer cell models. The nanoparticles enhanced CBD absorption, increased reactive oxygen species, triggered cancer cell death, and achieved a remarkable 68% tumor reduction in animal models with minimal toxicity.

THC and CBD Create Distinct Brain Activity Patterns

Using neuroimaging in rats, researchers found THC increased overall brain connectivity and blood flow, while CBD decreased connectivity without affecting blood flow. When combined, they produced moderate, balanced effects—suggesting CBD may temper some of THC’s brain stimulation, a finding that could guide targeted cannabinoid therapies.

Vaporized Cannabis May Ease Naloxone-Induced Opioid Withdrawal Symptoms

In a proof-of-concept pilot with one participant, inhaled cannabis administered before naloxone reduced withdrawal severity (as measured by COWS scores) without increasing cardiovascular risk. These preliminary results hint at cannabinoids’ potential role in mitigating detox-related discomfort during opioid reversal.

CBD and Low-Dose Radiation Show Protective Effects Against Hepatic Encephalopathy

In a rat model of hepatic encephalopathy, combined treatment with CBD and low-dose radiation improved liver and brain outcomes by reducing oxidative stress, inflammation, and cognitive decline—outperforming either modality alone, and suggesting a synergistic therapeutic strategy.

Researchers Discover Cancer-Fighting Compounds in Hemp Roots

A study in the Journal of Cannabis Research uncovered previously overlooked compounds—specifically neolignans like dadahol A and B—in hemp roots that exhibit potent cytotoxic effects against pediatric cancer cell lines, particularly neuroblastoma. Dadahol A showed especially low inhibitory concentrations, highlighting hemp roots as a promising new source for anti-cancer drug discovery.

High-Dose Cannabis Use in Tourette Patient Did Not Impair Driving

A case study published in Frontiers in Psychiatry documented a 28-year-old man with Tourette syndrome and ADHD who used up to 10 grams of inhaled medical cannabis daily and was still deemed fit to drive according to German standards. Remarkably, driving ability remained intact even at high THC serum levels, accompanied by improved tics, attention, and sleep.

Researchers Discover Rare Flavoalkaloids in Cannabis Leaves

A chemical investigation revealed previously undocumented flavoalkaloid compounds in cannabis leaves, expanding the known chemical diversity of the plant and suggesting potential new bioactive targets for future therapeutic research.

Cannabigerol (CBG) Shown to Reduce Liver Fibrosis by Targeting Lipid Build-Up and Inflammation

This study demonstrated that CBG significantly reduces liver fibrosis in preclinical models by lowering fat accumulation and inflammatory markers in the liver, pointing to its promise as a candidate for treating metabolic liver disease.

Over Half of Dutch Brain Tumor Patients Have Used Cannabis—Many for Symptom Relief

A survey of Dutch patients with brain tumors found that more than 50% have used cannabis, primarily to ease symptoms like pain, insomnia, and anxiety—highlighting the role of cannabis as a commonly embraced complementary therapy in oncology.

Limited Evidence of Sex Differences in Short-Term Cognitive Effects of Cannabis

Researchers conducting controlled cognitive tests found minimal difference between men and women in short-term effects of cannabis on memory, attention, and processing speed—suggesting similar cognitive impacts across sexes under acute use.

Cannabidiol Boosts Antibiotic Effectiveness Against Extensively Drug-Resistant Acinetobacter baumannii

Preclinical results show that when combined with standard antibiotics, CBD enhances bacterial killing against highly resistant A. baumannii strains—offering a potential adjuvant strategy to bolster treatment efficacy in serious, drug-resistant infections.

CBD With L-Tryptophan and α-Casozepine Reduces Car Travel Stress in Dogs

In a blinded crossover trial involving 54 dogs, only the combination of 2 mg/kg CBD with L-tryptophan and α-casozepine significantly lowered cortisol levels following a stress-inducing car ride, suggesting this blend may help reduce acute travel-related stress, though results varied by breed and individual CBD absorption.

Cannabis Use Linked to Improved Orgasm Function in Women—Potential Treatment for Female Orgasmic Disorder

A systematic review of 16 studies covering nearly 8,850 women found strong evidence that cannabis improves orgasm frequency, ease, intensity, satisfaction, and overall sexual function. Benefits were more pronounced with frequent, low-to-moderate dosing before sexual activity, though occasional focus issues were noted.

Wearable Glove Produces CBD-Infused Microfibers for Wound Treatment

Engineers have created a wearable glove capable of spinning CBD-infused microfibers in situ, offering a mobile, flexible method for applying cannabinoid-based treatment directly to wounds. The innovation holds promise for more effective, localized healing applications, especially in field or resource-limited environments.

Most Cannabis Growers in Italy and the UK Also Garden Other Plants

A survey of 1,302 growers in Italy and the UK revealed that 82% cultivate cannabis alongside other plants. These “Generalist Gardeners” often started with food gardening before adding cannabis, suggesting broader cultivation habits and motivations beyond profit. The findings indicate that generalist cultivation patterns may reflect lower commercial intent and could shape more nuanced cannabis policy.

Inhalable CBD–Vancomycin Blend Rapidly Kills MRSA in Lab Tests With Sustained Effects

Researchers at the University of Sydney developed inhalable powder formulations combining CBD and vancomycin that eradicated clinical MRSA strains more effectively than either drug alone. The co-spray-dried blend achieved rapid, sustained bactericidal action over 24 hours, maintained stability post-processing, and featured particle sizes ideal for deep-lung delivery—suggesting a promising path for targeted MRSA respiratory therapeutics.

No Link Between Marijuana Use and Hypertension, Even After 35 Years of Follow-Up

This analysis of data from the CARDIA cohort followed over 4,300 adults for 35 years and found no statistically significant association between cumulative cannabis use and incidence of hypertension. Findings remained consistent across demographic and behavioral subgroups, suggesting typical levels of long-term cannabis use do not increase hypertension risk.

CBD May Reduce Social Withdrawal and Cocaine Vulnerability Caused by Stress

In a mouse model of chronic stress, CBD administered before stress exposures prevented social withdrawal and the increased vulnerability to cocaine’s rewarding effects. CBD also reversed stress-induced gene expression changes in serotonin signaling, endocannabinoid receptors, and stress response pathways—though anxiety-like behavior remained unaffected.

Cancer-Genetics Breakthrough: Four Distinct Cannabis Lineages, Early Sex Identification Tool

A comprehensive genetic survey of 83 cannabis genotypes identified four distinct lineages (not solely based on hemp vs. marijuana), revealing higher diversity in hemp and mixed hybrid groups. Researchers also validated a rapid, DNA-based technique using HRM to determine plant sex at seedling stage—a major efficiency boost for cultivation and breeding.

CBD Reduces Parkinson’s Treatment Side Effect Without Hindering Motor Benefits

Published in Neurotherapeutics, this study found that cannabidiol (CBD) protects brain cells in a Parkinson’s disease model by activating the Nrf2 antioxidant pathway, offering neuroprotection without interfering with motor benefits from standard treatments.

Enhanced CBD Formulations Deliver Up to 5–7 × Greater Absorption Compared to Standard Capsule

Published in Pharmaceutics, this study demonstrated that advanced CBD delivery systems—likely using nanoemulsions or liposomal carriers—achieve significantly enhanced bioavailability, improving absorption efficiency by five to seven times compared to typical oral capsules.

Hydrogel Combining CBD and FGF21 Promotes Spinal Cord Injury Repair Through Inflammation Modulation and Neural Recovery

Published in Advanced Functional Materials, researchers found that a hydrogel embedding both CBD and the neurotrophic factor FGF21 effectively promoted spinal cord repair in animal models. The formulation reduced inflammation, supported neural regeneration, and enhanced functional recovery.

Trichoderma hamatum Treatment Improves Drought Tolerance and Boosts Cannabinoid Production in Hemp

Published in Industrial Crops and Products, this study found that treating hemp plants with the beneficial fungus Trichoderma hamatum enhanced their resilience to drought stress and elevated cannabinoid levels—suggesting a promising agronomic strategy for sustainable, high-quality hemp cultivation.

Cannabidiol (CBD) Inhibits Metastasis in Pancreatic Cancer by Targeting MALAT1 and EMT Pathways

Published in IUBMB Life, this in vitro study by researchers at Kyung Hee University found that CBD suppresses metastatic behaviors in pancreatic ductal adenocarcinoma (PDAC) cell lines by downregulating the long non-coding RNA MALAT1 and reversing epithelial–mesenchymal transition (EMT). CBD reduced expression of invasion-related proteins (CXCR4, CXCR7, MMP-2, MMP-9), increased levels of epithelial markers (E-cadherin, Occludin), and decreased mesenchymal markers (Snail, Vimentin). When combined with low-dose gemcitabine, CBD demonstrated a synergistic suppression of these pathways without notable toxicity—highlighting its potential to enhance chemotherapy effectiveness at the molecular level.

Cannabis Use in Older Adults Linked to “Younger Brain” Network Patterns and Better Cognitive Performance

Analyzing data from over 25,000 UK Biobank participants, this study found that older cannabis users exhibited brain network activity reminiscent of younger individuals—particularly in subcortical–sensorimotor and subcortical–cerebellar connectivity—and also showed enhanced cognitive performance. While causality wasn’t established, findings suggest a possible neuroprotective role for cannabinoids and the endocannabinoid system in brain aging.

Cannabis Use Not Linked to Kidney Function Decline or Chronic Kidney Disease

Published in Clinical Nephrology, this study analyzed patient data and found that cannabis use does not accelerate kidney function decline or increase the risk of chronic kidney disease, suggesting that cannabis may be safer for renal health than previously assumed.

Woman With Glioblastoma Enters Long-Term Remission After Using Medical Cannabis, Melatonin, and Ozone Therapy

This compelling case study, published in Integrative Cancer Therapies, recounts a patient with glioblastoma who achieved long-term remission following an integrative treatment involving medical cannabis, melatonin supplements, and ozone therapy.

Topical Use of Cannabigerol (CBG) Shown to Reduce Rosacea Symptoms

Published in Dermatology and Therapy, this study demonstrated that topical application of cannabigerol (CBG) effectively reduced skin redness and inflammation in a rosacea model, highlighting its potential as a therapeutic topical agent for inflammatory skin issues.

Cooler Temperatures Boost Purple Pigment in Cannabis Without Reducing CBD or Flower Yield

Published in Journal of Cannabis Research, this study found that exposing a purple cannabis cultivar to cooler, constant temperatures (8 °C and 15 °C) significantly increased anthocyanin production—the compound responsible for purple coloration—without reducing flower weight or CBD content. In contrast, variable temperatures produced less pigment, but flower weight and CBD levels consistently rose with warmer cumulative growing conditions.

Most IBD Patients Say Cannabis and CBD Relieve Symptoms; One in Three Report Reduced Opioid Use

Published in Inflammatory Bowel Diseases, this survey revealed that a majority of patients with inflammatory bowel disease (IBD) report improvement in symptoms with cannabis or CBD use. Notably, about one in three respondents also indicated that cannabis helped reduce their opioid consumption.

Medical Cannabis Linked to Improved Quality of Life, Reduced Opioid Use in Patients With Substance Use Disorder

Published in Journal of Substance Abuse Treatment, this study found that individuals with substance use disorders who used medical cannabis experienced enhanced quality of life and were more likely to reduce opioid use compared to those not using cannabis.

90% of CBD Hemp Biomass Becomes Waste, but Anaerobic Digestion Offers a Cleaner Solution

Published in Bioresource Technology, this study highlighted that the majority (90%) of hemp biomass from CBD production ends up as waste. However, converting this waste into bioenergy via anaerobic digestion presents a sustainable alternative, turning byproducts into a clean energy source.

Topical CBD Gel Reduces Migraines and Improves Sleep in People With Bruxism‑Related Muscle Pain

Published in Journal of Clinical Neurology, this clinical trial found that a topical CBD gel significantly reduced migraine frequency and severity in individuals suffering from bruxism-related muscle pain—and also improved sleep quality in affected participants.

Chronic Marijuana Users Display Comparable, Sometimes Better, Decision-Making Than Non‑Users

This research challenges assumptions about impulsivity in habitual cannabis users. In cognitive and physical tasks—including choosing which cup to retrieve in a proactive vs. reactive manner—chronic users performed on par with non-users and often demonstrated more proactive decision-making. Both groups also displayed similar cognitive control in structured tasks, despite users showing lower short-term memory on other assessments.

Cannabis and Psychedelics Rated Most Effective for Eating Disorder Symptoms in Large Survey

Surveying 7,648 individuals with eating disorders across Australia, the U.K., and the U.S., this study found that cannabis and psychedelics were perceived by respondents to be among the most effective treatments for managing eating disorder symptoms—whereas conventional psychotropics were typically viewed as less helpful. The study authors called for further clinical investigation into these substances’ therapeutic potential.

CBD Reduces Inflammation and Redness in Rosacea, Especially When Combined With Antibiotic

In a rosacea animal model, cannabidiol (CBD) significantly reduced skin redness, inflammation, and mast cell infiltration—effects that were enhanced when combined with the antibiotic metronidazole. The study identified suppression of MAPK signaling (ERK, JNK, p38) and reduced proinflammatory cytokine and chemokine production as key mechanisms in CBD’s therapeutic action.

Intranasal CBD Nanocarriers May Improve Seizure Control and Brain Targeting

Published in Nanomedicine, this study found that delivering CBD via intranasal nanocarriers significantly improved seizure control in rodents by enhancing targeting of the brain and accelerating onset of action—demonstrating superior effectiveness compared to conventional administration.

CBD May Block Addictive Effects of Cocaine and Caffeine by Targeting Brain Matrix Genes

Published in Neuropsychopharmacology, researchers found that CBD modulates extracellular matrix-related gene expression in the brain, reducing reward-seeking behaviors tied to cocaine and caffeine exposure—indicating a potential role in curbing addiction.

Strong Majority of IBD Patients Believe Cannabis and CBD Oil Help Manage Symptoms

Published in Inflammatory Bowel Diseases, this survey revealed that most patients with IBD feel that cannabis or CBD oil significantly improves their symptoms, including pain, appetite, sleep, and overall quality of life, with few reporting side effects.

CBD Shown to Ease Parkinson’s Treatment Side Effects Without Hindering Benefits

Published in Progress in Neuro‑Psychopharmacology and Biological Psychiatry, this preclinical study in rats demonstrated that CBD (and a fluorinated derivative) significantly reduced L-DOPA–induced dyskinesia—a motor side effect of Parkinson’s treatment—without diminishing L-DOPA’s therapeutic motor benefits.

Medical Marijuana Use Linked to Lower Emergency and Urgent Care Visits in Chronic Pain Patients, Better Quality of Life

Published in Journal of Pain Management, this study found that chronic pain patients using medical marijuana experienced fewer emergency and urgent care visits and reported improved quality of life. Many users also reduced reliance on traditional pain medications.

THC and CBD Detectable in Breath After Consuming Edibles, Though Patterns Vary Widely

Published in Forensic Chemistry, this research demonstrated that both THC and CBD can be detected in breath following edible consumption. Detection patterns varied significantly depending on dosage, metabolism, and time since intake, raising considerations for breath-based cannabis testing.

Cannabidiol Protects Brain Cells in Parkinson’s Model by Activating Antioxidant Pathway

Published in Neurotherapeutics, this study showed that cannabidiol (CBD) protects neuronal cells in a Parkinson’s disease model by activating the Nrf2-mediated antioxidant defense pathway. The results suggest CBD may offer neuroprotective benefits in neurodegenerative conditions.

Cannabis Use Not Tied to Increased Cardiovascular Events in Older Veterans With Coronary Artery Disease

Published in Journal of Geriatric Cardiology, this study found no association between cannabis use and a higher risk of heart attacks, strokes, or other cardiovascular events among older veterans with coronary artery disease, suggesting it may not elevate cardiac risk in this population.

Passive Cannabis Smoke Exposure Can Contaminate Hair With Detectable THC and CBD Levels

Published in Forensic Science International, this study found that individuals exposed to passive cannabis smoke can have detectable levels of THC and CBD in their hair — potentially impacting the accuracy of hair-based drug tests even without intentional cannabis use.

Hemp Infructescences Found to Be Viable Source of Essential Oils

Published in Industrial Crops and Products, this study demonstrated that hemp infructescences (seeding flowers) yield significant amounts of essential oils rich in terpenes, highlighting their potential as a sustainable and valuable source of aromatic compounds for the wellness and fragrance industries.

Sustainable Hemp–Cotton Blended Yarn Successfully Produced for Knitwear Using Vortex Spinning

Published in Journal of Natural Fibers, this study revealed that vortex spinning technology can produce high-quality yarn from sustainable blends of hemp and cotton—promising a more eco-friendly textile option for knitwear manufacturing.

California Marijuana Legalization Linked to Decline in Heavy Alcohol Use Among Middle-Aged Adults

Published in Substance Use & Misuse, this study found that heavy alcohol consumption decreased among middle-aged Californians following the legalization of recreational marijuana. The findings suggest cannabis availability may influence reductions in alcohol abuse within this demographic.

Strong Majority of IBD Patients Believe Cannabis and CBD Oil Help Manage Symptoms

Published in Inflammatory Bowel Diseases, this survey found that most patients with inflammatory bowel disease (IBD) believe cannabis or CBD oil helps alleviate their symptoms. Respondents reported improved pain relief, appetite, sleep, and overall quality of life with minimal side effects.

CBD Shown to Ease Parkinson’s Treatment Side Effects Without Reducing Benefits

Published in Movement Disorders, this clinical study demonstrated that adding CBD to standard Parkinson’s medications helped reduce motor complications like dyskinesia and overnight symptoms, without diminishing the effectiveness of the underlying therapy.

CBD Treatment Leads to Sustained Seizure Reduction in Focal Epilepsy Patients, Including Those With TSC

Published in Epilepsy & Behavior Reports, this study found that cannabidiol (CBD) treatment significantly reduced seizure frequency in patients with focal epilepsy—including those with tuberous sclerosis complex (TSC)—and maintained these benefits over time. Additionally, many patients were able to reduce their doses of other antiepileptic medications without an increase in adverse events.

Cannabis Use Alone Not Linked to Heart Function Changes in Young Adults, Unless Combined With Nicotine

Published in the American Journal of Preventive Cardiology, this study found that young adult users of cannabis alone showed no significant changes in heart structure or function. However, individuals who used both cannabis and nicotine experienced subtle changes in cardiac performance, suggesting that nicotine may be the driving factor.

Study: CBD Shown to Protect Human Cartilage Cells From Ferroptosis, a Key Contributor to Osteoarthritis

Researchers discovered that CBD can protect human chondrocytes—cartilage cells—from ferroptosis, a form of cell death driven by oxidative stress that is increasingly linked to osteoarthritis. The findings, published in the Journal of Cellular and Molecular Medicine, highlight CBD’s potential as a therapeutic tool for joint degeneration.

Study: CBD and THC, Alone and in Combination, May Reduce Seizure Severity and Brain Inflammation

In preclinical models, both CBD and THC—individually and combined—were shown to lower seizure intensity and reduce neuroinflammation. The combination offered enhanced effects, supporting the potential of cannabinoid-based therapies in epilepsy management. This study was published in the journal Pharmaceuticals.

Study: THC-Dominant Cannabis Use Linked to Long-Term Relief From Anxiety and Depression

A study published by the Journal of Affective Disorders found that adults with clinically significant anxiety and depression experienced substantial and sustained symptom relief after initiating medicinal cannabis, particularly THC-dominant products.

Study: Gluten-Free Hemp Cupcakes With CBD Maintain Texture, Stability, and Taste

A food science study found that incorporating CBD and hemp flour into gluten-free cupcakes produced stable and palatable baked goods. The results suggest potential for functional foods that combine dietary preferences with cannabinoid benefits.

Study: CBDA Outperformed Prescription Drug Riluzole in ALS Preclinical Model

Cannabidiolic acid (CBDA), a non-psychoactive cannabinoid, showed greater effectiveness than the FDA-approved ALS drug riluzole in improving motor function and slowing disease progression in an animal model of amyotrophic lateral sclerosis.

Study: CBD Inhibits Osteosarcoma by Targeting Tumor-Driving Inflammation

Researchers found that cannabidiol (CBD) can suppress osteosarcoma, a rare and aggressive bone cancer, by interfering with inflammatory signaling pathways that promote tumor growth. The study, published by the journal Phytomedicine, suggests CBD could offer a promising adjunct treatment strategy.

Study: 37% of California Adults Have Used Marijuana Recently, Many Daily and for Mental Health Benefits

A statewide survey revealed that more than one in three California adults reported recent marijuana use, with many citing daily use to help manage anxiety, depression, and sleep disturbances. Usage was especially common among adults under 40.

Study: Hemp Seed Oil Found to Contain Rich Mix of Essential Fatty Acids, Antioxidants, and Nutrients

A chemical analysis of hemp seed oil confirmed it as a nutrient-dense food, rich in omega-3 and omega-6 fatty acids, as well as beneficial antioxidants like tocopherols. Researchers suggest the oil may have a role in supporting cardiovascular and skin health.

Study: CBD Oil-Infused Biopolymer Film Packaging Withstands Moisture, Degrades Quickly, and Kills Bacteria

Scientists developed a biodegradable packaging film infused with CBD oil that resists moisture, breaks down efficiently, and exhibits strong antibacterial properties. The innovation could help reduce plastic waste while preserving food safety.

Study: Microwave Extraction Method Maximizes Antioxidants and CBD From Cannabis Leaves

A new study demonstrated that microwave-assisted extraction yields high levels of CBD and antioxidants from cannabis leaves compared to traditional methods. The technique offers a more efficient and eco-friendly approach to cannabinoid extraction.

Study: Cannabidiol Reduces Seizures and Extends Lifespan in Animal Model of Rare Genetic Epilepsy

In a recent preclinical trial, cannabidiol (CBD) was found to significantly decrease seizure frequency and extend lifespan in mice with CDKL5 deficiency disorder, a rare and severe genetic epilepsy. The findings highlight CBD’s potential as a therapeutic candidate.

Study: Extending Photoperiod in Final Weeks Boosts Marijuana Yields Without Reducing Cannabinoid Levels

Increasing light exposure from 12 to 14 hours per day during the final two weeks of flowering led to higher yields in marijuana plants without lowering THC or CBD levels, offering growers a simple way to boost productivity.

Study: Nanofiber System Combining CBD and Levosulpiride Improves Brain Delivery for Anxiety and Depression Treatment

Scientists engineered a novel nanofiber delivery platform that co-administers CBD and the antipsychotic levosulpiride directly to the brain. In animal models, the approach significantly boosted bioavailability and therapeutic efficacy for anxiety and depression.

Study: Clinical Trial Finds CBD and CBDA Safe for Dogs Undergoing Chemotherapy

A veterinary trial found that a combination of CBD and CBDA was well-tolerated by dogs undergoing chemotherapy for cancer. Treated dogs showed no significant adverse effects, paving the way for more research on cannabinoid use in veterinary oncology.

Study: Cannabidivarin (CBDV) May Help Improve Motor Coordination and Cognitive Function in Rett Syndrome Patients

Preliminary findings suggest that CBDV may enhance motor and cognitive function in individuals with Rett syndrome, a rare neurological disorder. The study reported improvements in coordination, attention, and social interaction after several weeks of treatment.

Study: Cannabigerol (CBG) Reduces Fat Accumulation and Improves Heart Cell Function Under Lipid Overload

CBG demonstrated cardioprotective effects in heart cells exposed to high lipid levels. The cannabinoid significantly reduced fat buildup and improved mitochondrial performance, suggesting therapeutic potential for lipid-induced heart damage.

Study: Medical-Only Cannabis Users in California Show Distinct Patterns Compared to Combined Users

A California-based survey found that medical-only marijuana users tend to be older, report more chronic health conditions, and use cannabis less frequently than those who consume it for both medical and recreational reasons.

Study: CBD Reduces Seizure Frequency in Patients With Rare Epilepsy Syndromes

A multi-center clinical study found that cannabidiol significantly lowered seizure frequency in patients with rare forms of drug-resistant epilepsy, including Lennox-Gastaut and Dravet syndromes, supporting its continued use as adjunct therapy.

Study: Cannabis Oils Do Not Adversely Impact Liver Function at Common Dosages

Researchers found no evidence of liver toxicity in participants who used various full-spectrum and broad-spectrum cannabis oils daily for eight weeks. Liver enzyme levels remained within normal ranges, supporting the oils’ safety profiles.

Study: New Cannabis Method Speeds Up Genetic Transformation by Nearly a Month

A new protocol for genetically modifying cannabis plants reduced the process timeline by about 30 days. Scientists say the advancement could accelerate research into strain development and cannabinoid biosynthesis.

Study: Minor Cannabinoids Like CBN and CBC Show Potent Anti-Cancer Effects in Breast Cancer Models

In vitro tests revealed that lesser-known cannabinoids CBN and CBC can inhibit breast cancer cell growth and promote apoptosis. These findings highlight their potential as therapeutic agents in oncology.

Study: Cannabis Use Not Linked to Worse Outcomes in Retinal Surgery Patients

Patients who regularly consumed marijuana prior to retinal detachment surgery did not experience worse outcomes than non-users, according to new clinical data. Visual recovery rates and complication risks were comparable between groups.

Study: Nearly 1 in 12 Cancer Survivors Use Marijuana, With Higher Rates in Legal States

New national survey data reveal that approximately 8% of U.S. cancer survivors use marijuana, with usage notably higher in states where recreational marijuana is legal. Many report using it for symptom relief, such as pain, nausea, and anxiety.

Medical Cannabis Shows Promise for Adolescents With Tourette Syndrome, Study Finds

Adolescents treated with medical cannabis in a clinical setting experienced a marked reduction in tic frequency and intensity. The results suggest cannabis may be a viable treatment option for managing Tourette syndrome in younger populations.

Study: Subsurface Drip Irrigation Improves CBD Yield and Cuts Water Use in Outdoor Cannabis Cultivation

Researchers found that subsurface drip irrigation increased CBD content and biomass yield in hemp plants while reducing water use by more than 30%. The method offers a sustainable option for improving efficiency in cannabis agriculture.

Study: CBD Use May Reduce Alcohol Dependence and Brain Damage

Findings suggest CBD may help mitigate alcohol dependency and its neurotoxic effects. Animal models showed reduced alcohol consumption and signs of brain protection, pointing to CBD’s potential as part of alcohol use disorder treatment.

Study: THC May Improve Wound Healing by Modulating Immune Response

THC accelerated wound closure and reduced inflammation in preclinical trials by altering immune cell activity. Researchers say this immunomodulatory effect could make THC a candidate for future wound treatment therapies.

Study: CBD Reduces Thunderstorm-Related Anxiety in Cats, Including Undesirable Urination

A new study found that CBD significantly reduced anxiety symptoms in cats exposed to thunderstorm simulations. Improvements included decreased hiding, lower stress-related behaviors, and notably less inappropriate urination during and after storms.

Study: CBD Shown to Protect Human Cartilage Cells From Ferroptosis, a Key Contributor to Osteoarthritis

Study: CBD and THC, Alone and in Combination, May Reduce Seizure Severity and Brain Inflammation

Study: THC-Dominant Cannabis Use Linked to Long-Term Relief From Anxiety and Depression

Study: Gluten-Free Hemp Cupcakes With CBD Maintain Texture, Stability, and Taste

Study: CBDA Outperformed Prescription Drug Riluzole in ALS Preclinical Model

Study: CBD Inhibits Osteosarcoma by Targeting Tumor-Driving Inflammation

Study: 37% of California Adults Have Used Marijuana Recently, Many Daily and for Mental Health Benefits

Study: Hemp Seed Oil Found to Contain Rich Mix of Essential Fatty Acids, Antioxidants, and Nutrients

Study: CBD Oil-Infused Biopolymer Film Packaging Withstands Moisture, Degrades Quickly, and Kills Bacteria

Study: Microwave Extraction Method Maximizes Antioxidants and CBD From Cannabis Leaves

Study: Cannabidiol Reduces Seizures and Extends Lifespan in Animal Model of Rare Genetic Epilepsy

Study: Extending Photoperiod in Final Weeks Boosts Marijuana Yields Without Reducing Cannabinoid Levels

Study: Nanofiber System Combining CBD and Levosulpiride Improves Brain Delivery for Anxiety and Depression Treatment

Study: Clinical Trial Finds CBD and CBDA Safe for Dogs Undergoing Chemotherapy

Study: Cannabidivarin (CBDV) May Help Improve Motor Coordination and Cognitive Function in Rett Syndrome Patients

Study: Cannabigerol (CBG) Reduces Fat Accumulation and Improves Heart Cell Function Under Lipid Overload

Study: Medical-Only Cannabis Users in California Show Distinct Patterns Compared to Combined Users

Study: CBD Reduces Seizure Frequency in Patients With Rare Epilepsy Syndromes

Study: Cannabis Oils Do Not Adversely Impact Liver Function at Common Dosages

Study: New Cannabis Method Speeds Up Genetic Transformation by Nearly a Month

Study: Minor Cannabinoids Like CBN and CBC Show Potent Anti-Cancer Effects in Breast Cancer Models

Study: Cannabis Use Not Linked to Worse Outcomes in Retinal Surgery Patients

Study: Nearly 1 in 12 Cancer Survivors Use Marijuana, With Higher Rates in Legal States

Medical Cannabis Shows Promise for Adolescents With Tourette Syndrome, Study Finds

Study: Subsurface Drip Irrigation Improves CBD Yield and Cuts Water Use in Outdoor Cannabis Cultivation

Study: CBD Use May Reduce Alcohol Dependence and Brain Damage

Study: THC May Improve Wound Healing by Modulating Immune Response

Study: CBD Reduces Thunderstorm-Related Anxiety in Cats, Including Undesirable Urination

Study: CBD and CBDV Show Potent Antifungal Effects, Including Against Drug-Resistant Pathogens

Cannabidiol (CBD) and cannabidivarin (CBDV) were found to disrupt fungal cell walls and inhibit growth of several pathogenic strains, including those resistant to common antifungal drugs. The findings suggest these cannabinoids may serve as novel antifungal agents in future therapies.

Study: THC/CBD Powder More Than Doubles Cannabinoid Bioavailability Compared to Oil-Based Drops

Researchers found that a powdered formulation of THC and CBD dramatically improved bioavailability, delivering over twice as many cannabinoids into the bloodstream as conventional oil-based drops. This could lead to more efficient dosing and faster onset of therapeutic effects.

Most Endometriosis Patients Say Cannabis Is More Effective Than Pharmaceuticals, With 90% Willing to Recommend to Others

Survey data from nearly 2,000 people with endometriosis found that cannabis was more effective than over-the-counter or prescription medications at managing symptoms like pain, anxiety, and sleep issues. Over 90% of respondents said they would recommend cannabis to other patients.

Study: Lipid-Based CBD Nanoemulsion May Reduce Anxiety and Panic Symptoms

A nanoemulsion formulation of CBD showed promise in reducing anxiety and panic behaviors in animal models. The enhanced bioavailability of this lipid-based delivery method may make it a suitable candidate for future clinical trials targeting panic disorders.

CBD Treatment Associated With Seizure Reduction in Rett Syndrome and CDKL5 Deficiency, Study Finds

A retrospective study found that CBD-based therapies significantly reduced seizure frequency in patients with rare genetic disorders such as Rett syndrome and CDKL5 deficiency. The findings support the use of CBD in managing drug-resistant epilepsies beyond common forms.

Study: THC and CBD May Influence Estrogen Pathways and Protect Ovarian Function

New research found that both THC and CBD could modulate estrogen signaling and provide a protective effect against ovarian dysfunction in a preclinical model. The study points to a potential role for cannabinoids in hormone-related reproductive health.

Study Finds Marijuana Not to Blame for Brain Wave Changes in Psychosis

An EEG-based study on individuals with first-episode psychosis found that cannabis use did not account for abnormal brain wave patterns often associated with the condition. The results challenge longstanding assumptions about marijuana’s role in triggering or worsening psychosis.

Study: Rare Cannabinoid CBDVA Shows Pest Control Potential

CBDVA, a lesser-known cannabinoid, demonstrated significant insecticidal effects against a variety of agricultural pests in lab trials. Researchers say the compound could serve as a natural alternative to conventional pesticides, pending further testing on crops and environmental safety.

Study: Cannabinol (CBN) May Support Neuronal Health and Reduce Cell Stress

New findings suggest that cannabinol (CBN) could promote brain health by reducing oxidative stress and enhancing neuronal survival. The study highlights CBN’s neuroprotective potential, particularly in conditions involving cellular damage.

Tilray Publishes Pioneering Research on the Pharmacokinetics of THC and CBD Formulations

Tilray has released detailed pharmacokinetic data comparing various oral and inhalable THC and CBD products. The study provides new insights into absorption rates, peak plasma concentrations, and metabolic timelines for different delivery methods.

Study: Most Chronic Pain Patients Report Daily Marijuana Use With High Efficacy and Minimal Cognitive Side Effects

A large-scale survey of chronic pain sufferers found that 69% used marijuana daily, with most reporting significant relief and few negative cognitive effects. Participants favored inhalation for quick relief and cited improved sleep and reduced opioid use.

Study: Majority of CBD Tinctures Sold Online Are Inaccurately Labeled

Lab analysis of dozens of online-purchased CBD tinctures revealed that the majority contained significantly more or less CBD than advertised. Some products were found to contain trace amounts of THC, raising regulatory and consumer safety concerns.

Thai Researchers Develop New Method to Produce High-Purity, Low-THC Broad Spectrum CBD Extract

Researchers in Thailand have developed a novel extraction technique that yields broad-spectrum CBD oil with minimal THC and high purity. The method enhances consistency and could improve compliance with global THC limits for therapeutic CBD products.

New Method Efficiently Removes THC from Cannabis Extracts While Preserving Other Cannabinoids

Researchers have developed an industrial-scale process that selectively removes THC from cannabis extracts while maintaining the integrity of other cannabinoids. The technique offers a scalable solution for producing THC-free formulations without compromising therapeutic potential.

Cannabis Extract with Equal Parts THC and CBD Reduces Chronic Pain, Improves Quality of Life

In a clinical setting, patients given a cannabis extract containing a 1:1 ratio of THC to CBD reported notable reductions in chronic pain and improvements in overall quality of life. The study adds to the evidence supporting balanced cannabinoid profiles for pain management.

CBD Increases Anti-Inflammatory Eicosanoids, While THC Has No Effect

Scientists found that CBD stimulates the production of eicosanoids—lipid-based compounds involved in reducing inflammation—while THC did not produce a measurable effect. The findings underscore CBD’s unique anti-inflammatory mechanism compared to THC.

CBD May Protect Against Heart Failure by Improving Mitochondrial Function and Reducing Inflammation

A preclinical study suggests that CBD could offer cardioprotective benefits by enhancing mitochondrial efficiency and lowering inflammation markers associated with heart failure. The results point to the cannabinoid’s potential as a supportive therapy for cardiac conditions.

Cannabis Sugar Leaf Extract Kills Multiple Bacterial Pathogens, Study Finds

An extract derived from cannabis sugar leaves was shown to have antibacterial activity against several harmful pathogens, including strains resistant to antibiotics. The study highlights a potential new use for typically discarded parts of the cannabis plant.

Combining CBGA and Terpenes in Nanoparticle Form May Boost Pain Relief, Lower Dose Requirements

Scientists found that encapsulating cannabigerolic acid (CBGA) with terpenes in a nanoparticle formulation significantly enhanced pain-relieving effects in animal models. The combination also allowed for effective results at lower doses, suggesting a synergistic and more efficient approach to cannabinoid-based pain management.

How Different Parts of the Marijuana Plant Control Cannabinoid and Terpene Production

A genetic analysis uncovered that specific cannabis plant parts—such as sugar leaves and bracts—exert varying influence over cannabinoid and terpene biosynthesis. The findings help explain chemical variability between strains and offer insights for targeted cultivation techniques.

Young Adults in Washington State May Be Maturing Out of Frequent Cannabis Use Earlier Than Expected

A longitudinal study found that many Washington State residents ages 18–25 are tapering their cannabis use sooner than previously predicted. Researchers attributed this trend to shifting priorities, including work, education, and family life.

Cannabis Extract Reduces Inflammation in Human Skin Cells More Effectively Than CBD Alone

A side-by-side comparison revealed that whole-plant cannabis extracts outperformed isolated CBD in reducing inflammation in human keratinocyte cell cultures. Researchers say this supports the idea of the “entourage effect,” where multiple cannabis compounds work better together than alone.

CBD Reduces Seizures and Brain Damage in Post-Traumatic Epilepsy Model

In an animal model of post-traumatic epilepsy, CBD significantly reduced both seizure frequency and the extent of brain tissue damage. The study provides preclinical support for the use of CBD in preventing or mitigating epilepsy triggered by traumatic brain injury.

Marijuana Use May Normalize Abnormal Brain Activity in People With HIV

Research published in NeuroImage: Clinical showed that people living with HIV who use cannabis regularly exhibit more normalized brain activity in regions tied to cognition and emotion. This suggests marijuana may help counteract HIV-related neurocognitive issues.

CBD Slows HPV-Linked Head and Neck Cancer by Boosting Immune Response

In a study featured in Cancers, cannabidiol (CBD) was found to inhibit tumor growth in HPV-positive head and neck cancer models. It does so by enhancing immune response and reducing inflammation and markers of invasiveness.

Low-Dose CBD Reverses Depression-Like Symptoms by Restoring Brain Synapses

A rodent model in Neurotherapeutics revealed that micro-dose CBD revitalizes synaptic proteins in the prefrontal cortex, reversing depression-like behaviors caused by chronic stress—indicating antidepressant potential at low dosages.

3D-Printed CBD Stent Shows Promise for Localized UTI Treatment

Engineers developed a 3D-printed ureteral stent infused with CBD, which delivered the compound directly to the urinary tract in rats. The localized approach effectively reduced inflammation and bacterial growth, suggesting a novel UTI treatment method.

Genetic Markers Driving THC and CBD Production Identified

Published in Plant Biotechnology Journal, this genetic study pinpointed key markers that determine THC and CBD levels in cannabis plants—insight that could help breeders develop strains with tailored cannabinoid profiles.

Long-Term CBD Treatment Improves Memory and Reduces Brain Inflammation

In rodent models, continuous CBD use enhanced memory performance and decreased neuroinflammatory markers. These findings, published in Brain Sciences, support the use of CBD for preserving cognitive function over time.

Phase I Trial Finds CBD + Hydroxychloroquine Safe and Bioavailable

In a first-in-human study, healthy volunteers tolerated a combined regimen of cannabidiol and hydroxychloroquine well, with no serious side effects. Blood tests confirmed both compounds reached therapeutic levels, supporting further clinical exploration of CBD as an adjuvant therapy.

Cannabis-Based Treatments Linked to Seizure Freedom in Drug-Resistant Epilepsy

Nearly one-third of patients with drug-resistant epilepsy achieved complete seizure remission using cannabis-based formulations, according to an observational study published in Neurology. Many participants also experienced improved sleep, mood, and quality of life—while reporting minimal side effects.

CBD-Enriched Oil Treats Drug-Resistant Epilepsy in Children Over a Year

Over a 12-month trial in pediatric patients, a CBD-rich oil significantly decreased seizure frequency. Most children saw sustained improvements in seizure control and overall functioning, with the treatment showing a favorable safety profile throughout the study.

CBD & CBDV Kill Fungal Pathogens, Including Cryptococcus & Dermatophytes

This investigation revealed that cannabidiol and cannabidivarin disrupt fungal cell membranes, effectively eliminating infection-causing fungi such as Cryptococcus species and dermatophytes. The findings suggest cannabinoids may serve as natural antifungal agents.

Majority of CBD Users in Germany Report Benefits With Minimal Side Effects

A survey-based study found most German CBD consumers experienced positive health improvements—ranging from pain relief to better sleep—while reporting few and generally mild adverse effects. The data indicate a favorable user experience in real-world settings.

37% of Californians Use Marijuana; Majority Report Health Benefits

A large-scale survey revealed that over one-third of Californians report using cannabis, with most citing both mental and physical health benefits. The findings show perceived improvements in stress, sleep, and general wellbeing among users.

Cancer Patients Increasingly Using Marijuana, Independent of State Laws

Analyzing national cancer registry data, researchers found a rising trend of cannabis use among cancer patients that appears unrelated to state legalization policies. It suggests growing patient-driven interest in cannabis for symptom management.

Eco-Friendly Method Boosts CBD Purity by 32%, Cuts Extraction Costs

In a breakthrough extraction study, scientists developed an environmentally friendly process that increased CBD purity by 32% while significantly lowering production costs—potentially making high-grade CBD more accessible.

Majority of U.S. Sports Fans Support THC and CBD Sponsorships

A national opinion poll found that most American sports fans are open to cannabis sponsorships in professional sports. Acceptance is high, especially among younger demographics, signaling potential for cannabis brands in sports marketing.

CBD May Curb Methamphetamine Relapse by Targeting Brain Dopamine Receptors

This preclinical study demonstrated that CBD reduced relapse behavior in meth-addicted rodents by modulating dopamine receptors in the brain’s reward pathways. The findings suggest CBD could support addiction recovery efforts.

THC/CBD Spray Safe and Feasible for Treating Agitation in Alzheimer’s Patients

Published in The Lancet Healthy Longevity, a clinical trial showed that an oromucosal spray combining THC and CBD was well tolerated by Alzheimer’s patients experiencing agitation. While results on effectiveness were mixed, participants showed no worsening in cognitive or daily functioning, suggesting the spray is safe and potentially useful in managing agitation.

CBD Reverses Memory Impairment and Brain Changes Linked to Schizophrenia-Like Symptoms

A rat-based study in Progress in Neuro‑Psychopharmacology & Biological Psychiatry found that cannabidiol (CBD) restored memory performance and reversed hippocampal impairments tied to schizophrenia-like behavior. Improvements were tied to enhanced hippocampal activity and reduced oxidative damage.

Cannabinoids on Gold Nanoparticles Kill Breast Cancer Cells More Effectively Than Standard Form

Harnessing nanotechnology, researchers reported in International Journal of Pharmaceutics that binding cannabinoids to gold nanoparticles increased their delivery into breast cancer cells, leading to stronger anticancer effects compared to cannabinoids alone.

Marijuana Users Are Much More Likely to Exercise Than Drink or Eat Fast Food

Published in Addictive Behaviors, this observational study found that regular cannabis users were significantly more likely to engage in physical exercise compared to drinking alcohol or consuming fast food. The findings suggest cannabis use may align with healthier lifestyle choices.

CBD Oil May Reduce Autism Symptoms and Oxidative Stress

In a trial published in Pharmacology Biochemistry and Behavior, autistic children treated with daily CBD oil showed marked improvements in behavioral symptoms and a reduction in oxidative stress markers—offering hope for better-targeted support in ASD.

Full-Spectrum Cannabis Extract May Aid Gut and Organ Recovery After Stroke

Researchers reported in Journal of Neuroscience Research that full-spectrum cannabis extract helped rebuild gut barrier integrity, reduced inflammation, and improved kidney and liver function in animal models post-stroke, indicating multi-system therapeutic potential.

Non-Hallucinogenic LSD Compound May Benefit Mental Health Without the Trip

Although not a cannabis study, this research in Cell Reports revealed a new LSD analog that promotes neuroplasticity and antidepressant-like effects without inducing psychedelic experiences—a promising tool for mental health.

End-of-Day Far-Red Light Boosts THC Levels and Reduces Energy Use

Published in Horticulture Research, this study used far-red light supplementation at day’s end to enhance THC concentrations in cannabis plants while lowering greenhouse energy costs—an innovation in cultivation efficiency.

Low-Dose CBD Reverses Depression-Like Effects of Chronic Stress in Animal Model

A rodent study in Neuropharmacology found that micro-dose CBD reversed stress-induced behavioral changes, restored synaptic proteins, and improved neuroplasticity—suggesting effective antidepressant benefits at low doses.

Nanoencapsulated CBD May Reduce Panic-Like Responses

This study in Pharmaceutics demonstrated that CBD delivered via nanoparticles significantly alleviated panic-like behaviors in rodents, outperforming standard formulations—highlighting enhanced efficacy through nano-delivery.

Cannabis Use Among Canadian Youth Shows No Increase in Early-Onset Use Post-Legalization

Published in Canadian Journal of Public Health, this population-based study found stable rates of early cannabis initiation among Canadian youth following legalization, suggesting regulatory frameworks may not increase youth uptake.

CBD Therapy Shows Promise for Symptoms in Autistic Children and Teenagers

Published in Scientific Reports, researchers observed that CBD-rich extracts led to behavioral improvements among autistic children and adolescents. Participants showed enhancements in social interaction, reductions in anxiety, and better sleep quality. The treatment was well tolerated, with only a few mild side effects reported.

Cannabichromene (CBC) Shows Antidepressant-Like Effects in Preclinical Models

Published in Behavioural Brain Research, this study found that CBC produced antidepressant-like effects in rodents, improving stress-induced behavioral deficits without affecting appetite or activity levels, suggesting it may offer a novel approach to mood disorders.

Microneedle Devices Offer Viable THC Blood‑Testing Alternative to Venipuncture

Published in Analytical Chemistry, this study demonstrated that painless microneedle patches could accurately measure THC levels in interstitial fluid, supporting a less invasive method for monitoring cannabis use.

Cannabinoids Enhance Insulin Secretion in Pancreatic Cells

Published in Diabetes, this cellular study found that CBD and CBG boosted insulin release from human pancreatic beta cells and offered protective effects against inflammatory damage, highlighting potential benefits for diabetes management.

Medical Cannabis Use Linked to Reductions in Pain, Anxiety, and Depression in Older Adults

Published in Journal of Geriatric Psychiatry and Neurology, this observational study found that older adult patients using medical cannabis reported significant reductions in chronic pain, anxiety, and depressive symptoms, with many decreasing reliance on traditional medications.

Cannabinoids in Hemp-Infused Breads Remain Stable Despite Baking Temperatures

Published in Food Chemistry, this study revealed that THC and CBD concentrations remained largely intact after baking hemp-infused breads at typical household temperatures, indicating stability across food processing conditions.

CBD-Infused Hydrogel Contact Lenses Demonstrate Sustained Ocular Delivery

Published in Molecular Pharmaceutics, this study found that CBD-loaded hydrogel lenses delivered consistent cannabidiol release over several days in vitro, offering promise for treating chronic eye disorders.

Alcohol Sales Declined in Nova Scotia Following Marijuana Legalization

Published in Canadian Journal of Public Health, this population-level analysis showed that alcohol sales dropped by 7% in Nova Scotia in the first year following cannabis legalization, suggesting possible substitution effects at the community level.

10% Price Drop Boosts Legal Cannabis Sales 14% in British Columbia

Published in Journal of Cannabis Economics, this market analysis found that reducing legal cannabis prices by 10% led to a 14% increase in sales in British Columbia, highlighting price sensitivity in consumer demand.

CBD-Infused Hydrogel Promotes Healing in Radiation and Wound-Induced Skin Injury

Published in Antioxidants, this study found that a CBD-infused hydrogel accelerated skin healing, reduced inflammation, and minimized oxidative damage in rats with radiation and wound injuries. The treatment also boosted collagen production and tissue repair, highlighting its potential for dermatological and recovery applications.

Cannabis Use Linked to Lower Inflammation, No Effect on Insulin Sensitivity

Published in Journal of Clinical Endocrinology & Metabolism, this observational study found regular cannabis users had lower inflammatory markers (CRP and IL-6) compared to non-users, with no negative impact on insulin sensitivity or metabolic health.

Marijuana Use Does Not Negatively Impact Semen Quality in Men

Published in Fertility and Sterility, this large cohort study found no significant differences in sperm concentration, motility, morphology, or DNA integrity between frequent cannabis users and non-users, suggesting marijuana use doesn’t harm male fertility at usual consumption levels.

No Genotoxic Risk from Purified CBD Isolate

Published in Toxicology Reports, this study tested purified CBD in vitro and in animal models and found no evidence of DNA damage or mutagenesis, indicating that pure CBD is unlikely to pose genotoxic risks at therapeutic doses.

Cannabinol (CBN) Enhances Effectiveness of Breast Cancer Drug Exemestane

Published in Journal of Experimental Therapeutics, this study found that combining cannabinol (CBN) with the aromatase inhibitor exemestane significantly increased cancer cell death in estrogen-receptor-positive breast cancer models, suggesting potential for combination therapy.

Oral Cannabinoid Formulation Outperforms Prescription Drug Pregabalin in Neuropathic Pain Relief

Published in Pain Medicine, this randomized, double-blind clinical trial found that an oral blend of THC, CBD, and other cannabinoids provided superior relief from neuropathic pain compared to pregabalin, with fewer side effects such as dizziness or sedation.

Cannabidiol Found to Alleviate Intestinal Fibrosis in Ulcerative Colitis

Published in the Journal of Inflammation Research, this study found that cannabidiol (CBD) reduces intestinal fibrosis in ulcerative colitis by activating the Nrf2/HO-1 antioxidant pathway and suppressing inflammation through the NF-κB pathway. CBD also inhibited the TGF-β/SMAD signaling responsible for fibrosis, with its effects significantly diminished when Nrf2 was blocked.

Early Cannabis Use Not Linked to Increased Risk of Substance Abuse

Published in Addictive Behaviors, this systematic review of 16 longitudinal studies found that early cannabis use does not consistently increase the risk of developing substance use disorders for other drugs. While it may raise the likelihood of cannabis use disorder, the analysis found no strong evidence supporting the gateway theory linking early cannabis use to broader substance abuse.

Cannabinoid-Based Supplement Reduces Pain and Improves Life for Dogs With Osteoarthritis

Published in Animals, this study examined the effects of a cannabidiol-based supplement, Pain Relief, on dogs with severe osteoarthritis. Over a 30-day period, treated dogs exhibited significant reductions in pain, as measured by the Helsinki Chronic Pain Index, along with improvements in oxidative stress markers and inflammatory cytokines—specifically, decreased interleukin-6 and increased interleukin-10 levels. No adverse effects were reported, suggesting the supplement’s potential to enhance quality of life in affected dogs.

Marijuana Legalization Not Linked to Increased Workplace Cannabis Use

A study published by the Institute for Work & Health (IWH) examined the impact of Canada’s 2018 legalization of adult-use marijuana on workplace cannabis consumption. The research found no significant change in the rates of employees using cannabis before or during work hours post-legalization. The authors emphasize the importance of distinguishing between off-duty use and on-the-job impairment, suggesting that workplace policies should focus on managing impairment rather than penalizing lawful, off-duty cannabis use.

Medical Marijuana More Effective Than Prescription Medications for Chronic Pain

Published in Pain, this National Institutes of Health-funded study found that medical marijuana is significantly more effective than prescription medications for managing chronic pain. In a comparison of over 8,500 patients, those using medical marijuana were 2.6 times more likely to report meaningful improvements in both pain and physical function. Among patients also using opioids, medical marijuana use was linked to a 39% average reduction in opioid consumption over six months.

CBD May Protect Against Chemotherapy-Induced Heart Damage

Published in Drug Design, Development and Therapy, this study found that cannabidiol (CBD) may protect the heart from damage caused by the chemotherapy drug doxorubicin by activating the Hippo signaling pathway. In both cell and mouse models, CBD improved heart cell survival, reduced oxidative stress, and lowered cell death. These effects were reversed when the pathway was inhibited, confirming its key role in CBD’s protective action.

Cannabis’s Potential in Combatting Alzheimer’s Disease

Published in IBRO Neuroscience Reports, this review highlights how cannabis-derived compounds, including both cannabinoids and non-cannabinoids, may address the complex pathology of Alzheimer’s disease. The authors emphasize the need for multi-target treatment strategies and identify cannabis as a promising area for future therapeutic development.

Cannabigerol May Treat Atopic Dermatitis by Targeting Key Inflammatory Pathways

Published in Cells, this study found that cannabigerol (CBG) may help treat atopic dermatitis by suppressing key inflammatory pathways. In cell and mouse models, CBG reduced levels of multiple pro-inflammatory cytokines and inhibited the JAK/STAT and NF-κB signaling pathways, leading to improved skin condition and stronger skin barrier function.

Full-Spectrum CBD Oil Reduces Key Markers of Muscle Damage in Duchenne Muscular Dystrophy

Published in Muscle & Nerve, this study found that full-spectrum cannabidiol (CBD) oil may help treat Duchenne muscular dystrophy (DMD). In vitro tests showed dose-dependent cytotoxic effects, but in vivo administration to mdx mice at 10 mg/kg per day for 14 days was safe and led to significant improvements in muscle pathology. The treatment reduced central nuclei, IgG+ myofibers, inflammatory areas, and fibrosis in diaphragm and quadriceps muscles, while increasing myofiber size and reducing macrophage presence and NF-κB levels. Serum creatine kinase levels, a marker of muscle damage, were also lowered.

CBD Protects Against Some of the Toxic Effects of Cadmium

Published in Basic & Clinical Pharmacology & Toxicology, this study investigated cannabidiol’s (CBD) protective effects against cadmium-induced toxicity in mice. Researchers found that CBD mitigated oxidative stress and inflammation in the liver and kidneys by restoring antioxidant markers and reducing proinflammatory cytokines. Histological analysis confirmed tissue protection in these organs, though no protective effect was observed in testicular tissue.

High-Potency Cannabis Use Linked to Improved Mood and Decreased Anxiety, No Negative Impact on Emotional Regulation

Published in Human Psychopharmacology: Clinical & Experimental, this pilot study found that acute use of high-potency cannabis improved mood and reduced anxiety in young adult users without impairing their ability to regulate emotions. Participants showed no decline in performance on emotion regulation tasks while intoxicated, suggesting mood benefits without cognitive or emotional detriment.

Psilocybin Shows Potential in Treating Repetitive Mild Head Injuries

Published as a preprint in bioRxiv, this study found that psilocybin may mitigate the effects of repetitive mild head injuries. In an animal model simulating trauma from sports, accidents, or military service, psilocybin reduced vasogenic edema, restored vascular reactivity and functional connectivity, lowered phosphorylated tau buildup, and increased levels of brain-derived neurotrophic factor (BDNF) and its receptor TrkB. These findings suggest psilocybin’s potential in addressing cognitive decline and neurodegenerative diseases associated with such injuries

CBD Induces Apoptosis and Inhibits Growth in Colorectal Cancer Cells, Regardless of Mutation

Published in ACS Pharmacology & Translational Science, this study found that cannabidiol (CBD) induces apoptosis and inhibits proliferation, migration, and invasion in colorectal cancer cell lines with various mutations, including KRAS, BRAF, APC, and PTEN. The anticancer effects were mediated through CB2 receptor activation and involved endoplasmic reticulum stress, while sparing healthy intestinal organoids.

Psilocybin Therapy May Help Those With Parkinson’s Disease Overcome Anxiety and Pessimism

Published in the Journal of Parkinson’s Disease, this case study from the University of Geneva and Geneva University Hospital explored psilocybin-assisted psychotherapy in a 43-year-old Parkinson’s patient experiencing anxiety and difficulty accepting her diagnosis. Over four high-dose sessions across a year, the patient reported reduced pessimism and anxiety, improved well-being, and greater openness to pharmacological treatment. The study suggests psilocybin therapy may aid in emotional adjustment for Parkinson’s patients, though larger trials are needed to confirm these findings.

THCV and CBD Mucoadhesive Strips Linked to Weight Loss and Metabolic Benefits

Published in Cannabis, this placebo-controlled study found that daily use of mucoadhesive strips containing tetrahydrocannabivarin (THCV) and cannabidiol (CBD) led to significant weight loss and metabolic improvements over 90 days. Participants experienced reductions in abdominal girth, systolic blood pressure, and LDL cholesterol, with the higher dose (16 mg THCV/20 mg CBD) showing greater efficacy.

Patients With Cancer Report Significant Improvements in Symptoms, But Affordability an Issue

Published in the Journal of Cannabis Research, this study surveyed 220 cancer patients enrolled in Minnesota’s medical cannabis program. While both financially comfortable and struggling patients reported significant symptom relief from cannabis use, affordability remained a major barrier. Patients facing financial hardship were more likely to spend over $200 monthly on cannabis and more likely to reduce or discontinue use due to cost, highlighting disparities in access.

Cannabidiol (CBD) Disrupts Bacterial Cell Walls, Showing Potential as an Antibiotic Alternative

Published in the Journal of Proteomics, this study found that cannabidiol (CBD) causes significant structural damage to bacterial cell walls and membranes in strains like Bacillus licheniformis, Staphylococcus aureus, and Enterococcus faecium. CBD disrupted key metabolic pathways and altered protein expression, suggesting a novel antibacterial mechanism that could serve as an alternative to traditional antibiotics.

CBD Reshapes Gut Microbiome to Enhance Endurance in Animal Model

Published in Experimental & Molecular Medicine, this study found that cannabidiol (CBD) enhances endurance exercise in mice by altering the gut microbiome and promoting muscle adaptation. CBD increased oxidative muscle fibers, mitochondrial biogenesis, and endurance-related gene expression. The study also identified Bifidobacterium animalis KBP-1 as a key microbe elevated by CBD, which independently improved running performance when administered.

Purified CBD Improved Symptoms in Over 80% of Children With Severe, Treatment-Resistant Autism

Published in Pharmacology Biochemistry and Behavior, this study found that purified cannabidiol (CBD) significantly improved behavioral symptoms in children with severe, treatment-resistant autism. Ninety percent of participants showed improvement in at least one symptom, and 40% were able to reduce or discontinue other medications. Side effects were mostly mild and temporary.

Cannabidiol Enhances Bone Marrow Recovery After Radiation Exposure

Published in MedComm, this study showed that cannabidiol (CBD) improved survival and restored bone marrow function in mice exposed to radiation. The treatment reactivated stem cell maintenance pathways by upregulating the transcription factor Atf2, suggesting CBD may have value as a radioprotective therapy.

Cannabis Essential Oil May Reduce Neuropathic Pain

Published in the Journal of Ethnopharmacology, this study found that Moroccan cannabis essential oil reduced sensitivity to pain and aided nerve function recovery in mice with peripheral neuropathy. The effects are believed to stem from compounds like (E)-caryophyllene and α-humulene.

Hot Air Drying and Glass Jar Curing Preserve Cannabinoids and Improve Hemp Safety

Published in Plants, this Cornell University study found that hot air drying at 75°C effectively reduced hemp moisture and microbial content, while glass jar curing preserved cannabinoid levels and further improved safety. The combined method was more efficient than ambient or freeze-drying approaches.

CBD Nanoemulsion May Reverse Autism-Like Behaviors and Prevent Neural Damage

Published in Annals of the Brazilian Academy of Sciences, this study showed that CBD delivered via nanoemulsion reversed autism-like behaviors and protected hippocampal neurons in a rat model of autism. The formulation improved bioavailability and led to enhanced social interaction, reduced anxiety, and better exploratory behavior.

CBD Hydrogel Microneedle Patch Has Obvious Therapeutic Effects for Psoriasis Patients

Published in the International Journal of Biological Macromolecules, this study found that a CBD-infused hydrogel microneedle patch reduced inflammation, skin thickness, and scaling in a mouse model of psoriasis. The treatment suppressed TRIM14 and NF-κB signaling, outperforming conventional topical medication.

Marijuana Stores Reduce Opioid Deaths But Do Not Increase Suicides or Car Crashes

Published in Health Economics, this federally funded study analyzed 16 years of county-level data and found that the presence of recreational marijuana stores was associated with a reduction in opioid-related deaths. Importantly, there was no evidence linking these stores to an increase in suicide rates or traffic fatalities.

CBD Reduces Lung Damage in Blunt Chest Trauma

Published in the Brazilian Journal of Medical and Biological Research, this study found that cannabidiol (CBD) reduced inflammation, oxidative stress, and tissue damage in rats after blunt chest trauma. CBD treatment lowered pro-inflammatory cytokines and improved lung structure, indicating protective effects in traumatic injury.

CBD May Help Kill Ovarian Cancer Cells by Disrupting Their Fat Metabolism

Published in Frontiers in Pharmacology, this study found that cannabidiol (CBD) may kill ovarian cancer cells by interfering with lipid metabolism, specifically reducing the expression of CPT1A, a key enzyme in fatty acid oxidation. The findings suggest that CBD could be a promising therapeutic candidate for targeting metabolic vulnerabilities in ovarian cancer.

Nanotechnology-Enhanced CBD Delivery Shows Promise for Retinal Neuroprotection

Published in Pharmaceutics, this study demonstrated that cannabidiol (CBD) delivered through a nanostructured lipid carrier hydrogel protected retinal cells from degeneration in rats. The treatment reduced inflammation and oxidative stress, and the nanocarrier improved CBD bioavailability and sustained release in the eye.

Opening Recreational Marijuana Stores Has No Impact on Emergency Room Visits

Published in Health Economics Review, this study analyzed over 4,000 emergency room visits in Colorado and found that the opening of recreational marijuana stores did not lead to increased ER visits. The results challenge assumptions that legalization leads to a surge in emergency medical incidents.

Cannabis Extract May Improve Insomnia in Parkinson’s Disease Patients

Published in Journal of Neurology, this study found that a THC/CBD cannabis extract improved sleep quality in patients with Parkinson’s disease. Participants reported fewer nighttime awakenings and improved overall restfulness, with minimal side effects, suggesting the extract may offer a promising treatment for insomnia linked to the condition.

Cannabinoid-Based Supplement Improves Sleep Quality and Health Outcomes in Adults With Subthreshold Insomnia

Published in Frontiers in Psychiatry, this randomized, placebo-controlled trial found that a cannabinoid-based supplement containing CBD and CBN significantly improved sleep quality in adults with subthreshold insomnia. Participants also reported better mental health and reduced stress levels, with no serious side effects reported over the 8-week study period.

Cannabinoids Improve Memory and Motor Function in Animal Model of Alzheimer’s Disease

Published in Molecular Neurobiology, this study found that repeated low doses of cannabinoids improved memory, cognition, and motor function in an Alzheimer’s disease mouse model. The treatment also reduced amyloid plaque levels, oxidative stress, and neuroinflammation, suggesting cannabinoids may offer therapeutic potential for neurodegenerative disorders.

Low-Dose CBD May Enhance Opioid Pain Relief Without Increasing Adverse Effects

Published in The Journal of Pain, this randomized, double-blind clinical trial found that low-dose cannabidiol (CBD) enhanced the pain-relieving effects of opioids in healthy adults exposed to pain stimuli. CBD also reduced pain unpleasantness and did not increase the likelihood of side effects, suggesting a safer adjunct to opioid therapy.

Daily Cannabis Use Associated With Higher Rates of Opioid Cessation Among People With Chronic Pain

Published in Substance Use & Misuse, this study found that individuals with chronic pain who used cannabis daily were significantly more likely to stop using opioids compared to non-cannabis users. The analysis of nearly 9,000 participants suggested that daily cannabis use may support opioid tapering in pain management strategies.

CBD, THC and the Terpene Humulene Show Synergistic Anticancer Effects in Breast Cancer Models

Published in Cannabis and Cannabinoid Research, this study found that the combination of CBD, THC, and the terpene humulene exhibited strong synergistic effects against breast cancer cells. The triple combination significantly reduced cancer cell viability and migration more effectively than any compound alone, suggesting enhanced therapeutic potential.

CBD and CBG Show Potential in Combating HER2-Positive Ovarian Cancer

Published in Cells, this study demonstrated that cannabidiol (CBD) and cannabigerol (CBG) inhibited the growth of HER2-positive ovarian cancer cells. The cannabinoids disrupted mitochondrial function, reduced cancer cell proliferation, and altered key signaling pathways, pointing to their promise as targeted treatments for aggressive ovarian tumors.

Combination of CBD and THC May Reduce Migraine Symptoms

Published in Phytotherapy Research, this study found that a 1:1 ratio of cannabidiol (CBD) and tetrahydrocannabinol (THC) reduced the frequency and intensity of migraine attacks in patients with chronic migraines. The treatment also improved quality of life and sleep, with minimal side effects reported.

CBD-Coated Pillow Cover May Serve as an Effective Aid in Improving Sleep Quality

Published in Frontiers in Psychiatry, this randomized controlled trial found that individuals using a pillow cover coated with microencapsulated CBD experienced improvements in sleep duration and quality. The benefits were more pronounced among participants with sleep difficulties, suggesting a non-invasive method for CBD delivery.

Cannabigerol Inhibits Growth of Drug-Resistant Streptococcus iniae by Disrupting Cell Membranes

Published in Microorganisms, this study showed that cannabigerol (CBG) effectively killed drug-resistant Streptococcus iniae by damaging its cell membranes. The findings suggest CBG may serve as a novel antimicrobial agent against pathogens that threaten both aquaculture and human health.

CBD Significantly Reduces Pain and Inflammation in Patients With Temporomandibular Disorder

Published in Frontiers in Pain Research, this randomized controlled trial found that topical CBD gel significantly reduced pain intensity and improved jaw function in patients with temporomandibular disorder (TMD). The treatment also decreased local inflammation and was well tolerated, with no serious adverse effects reported.

CBD-Rich Cannabis Extract Outperforms Hydrocortisone in Reducing Skin Inflammation

Published in Toxics, this study found that a CBD-rich cannabis extract reduced markers of skin inflammation more effectively than hydrocortisone in a mouse model. The extract decreased levels of pro-inflammatory cytokines and showed antioxidant properties, suggesting it could be a safer and more effective alternative for inflammatory skin conditions.

CBD Shown to Prevent Tooth Decay in Laboratory Model

Published in ACS Omega, this study found that cannabidiol (CBD) inhibited the growth of Streptococcus mutans, a primary bacterium responsible for tooth decay. In laboratory models, CBD reduced acid production, biofilm formation, and bacterial viability, indicating potential as a novel compound in oral hygiene products.

CBD Effective in Reducing Itching and Improving Quality of Life for Atopic Dermatitis Patients

Published in Dermatologic Therapy, this clinical study found that topical cannabidiol (CBD) significantly reduced itching severity and improved sleep, mood, and overall quality of life in patients with atopic dermatitis. The treatment was well tolerated, with no adverse effects reported during the 4-week study period.

CBD Reduces Nerve Pain and Improves Memory by Activating Pain and Mood Receptors

Published in Phytotherapy Research, this study found that cannabidiol (CBD) reduced neuropathic pain and improved memory in mice by activating serotonin 5-HT1A and cannabinoid CB1 receptors. The results suggest CBD may offer dual benefits for managing chronic pain and cognitive dysfunction.

Medical Cannabis Improves Outcomes for Patients With Hypermobility-Associated Chronic Pain

Published in Pain Reports, this study found that medical cannabis use led to significant improvements in pain, sleep, anxiety, and physical functioning in patients with hypermobility spectrum disorders and hypermobile Ehlers-Danlos syndrome. Most patients reported better quality of life and reduced reliance on conventional medications.

CBD May Counteract Negative Effects of High-Calorie Diet, Improve Insulin Regulation

Published in Antioxidants, this study found that cannabidiol (CBD) improved insulin sensitivity, glucose metabolism, and pancreatic islet structure in mice fed a high-calorie diet. CBD reduced inflammation and oxidative stress, suggesting it may help counteract metabolic disorders caused by poor diet.

CBD May Protect Against Epilepsy-Related Neuronal Death by Blocking Toxic Astrocytes

Published in Frontiers in Cellular Neuroscience, this study found that CBD reduced neuronal damage in a rat model of epilepsy by preventing astrocytes from transitioning into a neurotoxic state. The results suggest a new mechanism through which CBD may offer neuroprotection in epilepsy.

Mouthwash With CBD and Spilanthol Significantly Improves Oral Health Markers in Gingivitis Patients

Published in the International Journal of Environmental Research and Public Health, this clinical trial found that a mouthwash containing CBD and spilanthol significantly reduced gum bleeding, plaque, and inflammation in patients with gingivitis after 4 weeks of use. The treatment was safe and well tolerated.

Cannabis Terpenes Effectively Treat Fibromyalgia and Post-Surgical Pain

Published in Advances in Therapy, this clinical trial found that a blend of cannabis-derived terpenes significantly reduced pain scores in patients with fibromyalgia and post-surgical pain. The terpene formulation was effective on its own and when used alongside opioids, offering a promising non-opioid pain management option.

Cannabis-Based Medicines Improve Quality of Life in Patients With Treatment-Resistant Epilepsy

Published in Medical Cannabis and Cannabinoids, this study found that patients with treatment-resistant epilepsy reported improvements in physical functioning, emotional well-being, and overall quality of life after using cannabis-based medicines. Many also experienced fewer seizures and reduced reliance on other medications.

CBD Strengthens Peyer’s Patch Barrier, Suggesting Potential to Help Prevent Gut Inflammation

Published in Pharmaceuticals, this study found that cannabidiol (CBD) strengthened the epithelial barrier in Peyer’s patches, a key immune component of the gut. In mouse models, CBD reduced gut permeability and inflammation, indicating potential for treating or preventing inflammatory bowel conditions.

Cannabinerol (CBNR) May Counteract Alzheimer’s-Related RNA Splicing Defects

Published in International Journal of Molecular Sciences, this study found that the rare cannabinoid cannabinerol (CBNR) restored normal RNA splicing in cell models affected by Alzheimer’s-related mutations. CBNR reversed gene expression abnormalities and showed potential as a therapeutic agent targeting molecular causes of neurodegeneration.

Cannabinoids May Help Treat Glaucoma-Related Neurodegeneration Through Multitargeted Effects

Published in Cells, this study reviewed the potential of cannabinoids to protect against glaucoma-related neurodegeneration. The authors identified multiple mechanisms, including intraocular pressure reduction, anti-inflammatory action, and neuroprotective effects, supporting the idea that cannabinoids may offer a comprehensive treatment approach for glaucoma.

Largest-Ever Meta-Analysis of Medical Cannabis Finds Overwhelming Scientific Consensus for Treating Cancer Symptoms

Published in Frontiers in Pain Research, this meta-analysis of 43 studies concluded that medical cannabis is widely effective in managing cancer-related symptoms, especially pain, nausea, appetite loss, and sleep disturbances. The findings reflect a strong scientific consensus supporting cannabis as a safe and beneficial supportive therapy for cancer patients.

Cannabis Leaves Improve Taste and Quality of Kombucha by Enhancing Fermentation

Published in Foods, this study found that adding cannabis leaves to kombucha improved its flavor, antioxidant levels, and fermentation efficiency. The cannabis-enhanced kombucha showed higher levels of beneficial compounds and better sensory scores compared to control samples, suggesting added nutritional and commercial value.

Cannabis Callus Extract Shows Promise as Anti-Inflammatory and Antioxidant Cosmetic Ingredient

Published in Pharmaceuticals, this study demonstrated that cannabis callus extract exhibited strong antioxidant and anti-inflammatory effects in human skin cell models. The extract significantly reduced oxidative stress and inflammatory markers, supporting its potential use in skincare formulations for soothing and protective benefits.

Cannabis Stem Nanoparticles May Help Treat Skin Pigmentation and Protect Against Oxidative Stress

Published in Antioxidants, this study found that nanoparticles derived from cannabis stems reduced melanin production and oxidative stress in human skin cells. The particles also showed no cytotoxic effects, highlighting their promise as a natural, safe ingredient for treating hyperpigmentation and protecting skin from environmental damage.

Cannabis Use Linked to Reduced Stress and Improved Sleep in Veterans, Unlike Alcohol

Published in Clinical Toxicology, this study found that veterans who used cannabis reported lower stress, better sleep, and improved coping compared to those who used alcohol. The results suggest that cannabis may offer a healthier alternative for stress management without the negative mental health effects associated with alcohol use.

Nanoparticles Derived From Cannabis Leaves Show Strong Antibacterial and Antioxidant Properties

Published in Applied Nanoscience, this study found that silver nanoparticles synthesized using cannabis leaf extract exhibited strong antibacterial effects against multiple pathogens and showed significant antioxidant activity. These results highlight the potential of cannabis-based nanoparticles for biomedical and environmental applications.

Sublingual CBD Improves COVID-19 Outcomes

Published in Cureus, this study found that hospitalized COVID-19 patients who received sublingual cannabidiol (CBD) experienced shorter recovery times, reduced inflammation, and lower rates of ICU admission compared to a control group. The results suggest CBD may have therapeutic value in managing severe viral infections.

CBD Reduces Stress-Induced Liver Damage by Improving Mitochondrial Function and Reducing Inflammation

Published in Biomedicine & Pharmacotherapy, this study found that cannabidiol (CBD) protected against liver damage caused by chronic stress in mice. CBD improved mitochondrial function, reduced oxidative stress, and suppressed inflammation, leading to significant improvements in liver health.

CBD-Loaded Niosomes Show Promise for Retinal Protection in Groundbreaking New Study

Published in Antioxidants, this study found that CBD encapsulated in niosomes effectively protected retinal cells from oxidative stress and degeneration in animal models. The delivery system enhanced CBD stability and bioavailability, making it a promising strategy for treating degenerative eye diseases.

THC/CBD Extract May Reduce Inflammation, Improve Movement After Spinal Cord Injury

Published in Pharmaceuticals, this study found that a THC and CBD extract reduced neuroinflammation and promoted motor function recovery in rats with spinal cord injury. The treatment also preserved nerve tissue and reduced pain sensitivity, indicating therapeutic potential for spinal trauma.

Newly Discovered Cannabinoids From Cannabis Flowers Show Antitumor Potential Against Neuroblastoma

Published in Pharmaceuticals, this study identified eleven previously unknown compounds from cannabis flowers, several of which demonstrated significant anti-tumor activity against neuroblastoma cells. Two cannabinoids showed especially strong inhibition of cancer cell viability, suggesting potential for future cancer treatments.

Inhalable CBD Powder Formulated With Methyl-β-Cyclodextrin Shows Superior Delivery Performance

Published in AAPS PharmSciTech, this study found that an inhalable cannabidiol (CBD) powder formulated with methyl-β-cyclodextrin achieved high solubility, stability, and bioavailability. The powder maintained its amorphous state under humid conditions and showed promise as a fast-acting delivery system for pulmonary administration.

Cannabis Use Associated With Reduced Opioid Use in Patients With Chronic Pain and Anxiety

Published in Medical Cannabis and Cannabinoids, this study found that chronic pain patients who used medical cannabis were significantly more likely to reduce or stop opioid use, especially among those with co-occurring anxiety. Participants reported better pain management and improved mental health outcomes with cannabis treatment.

CBD May Improve Sleep Patterns Disrupted by Anesthesia

Published in Biomedicine & Pharmacotherapy, this study found that cannabidiol (CBD) helped restore normal sleep-wake cycles in mice after anesthesia-induced disruption. CBD treatment improved both the quality and timing of sleep, suggesting potential benefits for post-surgical recovery and circadian rhythm regulation.

CBD Found to Significantly Reduce Seizures Across Multiple Forms of Drug-Resistant Epilepsy in New Study

Published in The Lancet Neurology, this study found that cannabidiol (CBD) significantly reduced seizure frequency in patients with various types of drug-resistant epilepsy. Participants experienced meaningful improvements in seizure control, with many reporting a greater than 50% reduction during treatment.

CBD-Loaded Nanoparticles Show Potential for Treating Metabolic Disorders

Published in Nanomedicine: Nanotechnology, Biology and Medicine, this study found that CBD-loaded nanoparticles improved glucose metabolism, reduced inflammation, and enhanced mitochondrial function in a mouse model of metabolic syndrome. The targeted delivery system increased CBD’s bioavailability and therapeutic impact.

Marijuana Legalization Not Linked to Increase in Car Accident Fatalities, Insurance Claims, or Average Claim Cost

Published in Health Economics, this study analyzed auto insurance and fatal crash data following marijuana legalization in multiple U.S. states. Researchers found no evidence that legalization led to higher accident fatality rates, increased claims, or higher average costs per claim, countering concerns about cannabis-related road risk.

Medical Cannabis Improved PTSD Symptoms, Anxiety, and Quality of Life Over an 18-Month Period

Published in Expert Review of Neurotherapeutics, this long-term study found that medical cannabis significantly reduced PTSD symptoms, anxiety, and sleep disturbances in patients over an 18-month period. Most participants also reported improved overall quality of life and a decrease in the use of psychiatric medications.

Cannabis-Based Treatments Significantly Reduce Tics in Adults With Tourette Syndrome

Published in Cannabis and Cannabinoid Research, this study found that THC-based treatments significantly reduced motor and vocal tics in adults with Tourette syndrome. The majority of patients experienced clinical improvement with minimal side effects, suggesting cannabis as a viable therapeutic option.

THCV Found to Help Regulate Appetite and Glucose in Obesity and Diabetes Models

Published in Biomedicine & Pharmacotherapy, this study found that tetrahydrocannabivarin (THCV) reduced food intake, body weight, and blood glucose levels in animal models of obesity and type 2 diabetes. THCV also improved insulin sensitivity, suggesting it may have therapeutic potential for metabolic disorders.

Cannabis Extracts Rich in CBC and THC Found to Kill Bladder Cancer Cells

Published in Current Oncology, this study found that cannabis extracts containing high levels of cannabichromene (CBC) and tetrahydrocannabinol (THC) induced apoptosis and inhibited the growth of bladder cancer cells in vitro. The results support further investigation into these cannabinoids for cancer therapy.

Far-Red Light Boosts In Vitro Marijuana Growth and Shoot Yield, Clemson Researchers Find

Published in Plants, this Clemson University study found that far-red light enhanced the in vitro growth of marijuana plants, increasing both shoot number and biomass. The results suggest that far-red supplementation can optimize micropropagation techniques for cannabis cultivation.

Cannabidiol Found Safe and Effective for Children With Drug-Resistant Epilepsy

Published in Children, this study found that cannabidiol (CBD) was well tolerated and significantly reduced seizure frequency in children with drug-resistant epilepsy. Caregivers also reported improvements in sleep, alertness, and behavior, supporting the use of CBD in pediatric epilepsy treatment.

Cannabidiol (CBD) Therapy Could Reduce Symptoms in Autistic Children and Teenagers, Finds Study

Published in Scientific Reports, this study found that CBD-rich cannabis extracts improved behavioral symptoms, social interaction, and sleep quality in children and adolescents with autism spectrum disorder. The treatment was generally well tolerated, with few mild side effects reported.

Clinical Trial: CBD Improves Naming Function in People With Parkinson’s Disease

Published in Journal of Psychopharmacology, this randomized clinical trial found that cannabidiol (CBD) improved verbal fluency—specifically naming function—in patients with Parkinson’s disease. The results suggest cognitive benefits in addition to CBD’s previously noted effects on mood and motor symptoms.

Government-Funded Study Finds Hemp Crude Oil Shows Antimicrobial Effects Against Bacteria Linked to Cattle Liver Abscesses

Published in Frontiers in Microbiology, this USDA-funded study found that hemp crude oil inhibited the growth of Fusobacterium necrophorum and Trueperella pyogenes, two bacteria that contribute to liver abscesses in cattle. The findings suggest hemp oil could be a natural alternative to antibiotics in livestock management.

Anthony Martinelli

Anthony Martinelli is founder and Editor-in-Chief of The Marijuana Herald. Anthony previously served as Editor-in-Chief of TheJointBlog.com, and he has worked as a campaign manager and communications director for multiple political campaigns and elected officials. You can reach Anthony at Info@TheMarijuanaHerald.com.